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Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila Soheili, Zahra, Esfahani, Kasra. (1403). β-cyclocitral Extracted from Galium mite (medicinal herb) and the Evaluation of its Effect in MCF-7 Cell Lines. سامانه مدیریت نشریات علمی, 13(4), 1072-1078. doi: 10.22034/jmpb.2024.362994.1585
Alireza Shabani; Mohammad Zaefizadeh; Mohsen Farhadpour; Zahra Soheila Soheili; Kasra Esfahani. "β-cyclocitral Extracted from Galium mite (medicinal herb) and the Evaluation of its Effect in MCF-7 Cell Lines". سامانه مدیریت نشریات علمی, 13, 4, 1403, 1072-1078. doi: 10.22034/jmpb.2024.362994.1585
Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila Soheili, Zahra, Esfahani, Kasra. (1403). 'β-cyclocitral Extracted from Galium mite (medicinal herb) and the Evaluation of its Effect in MCF-7 Cell Lines', سامانه مدیریت نشریات علمی, 13(4), pp. 1072-1078. doi: 10.22034/jmpb.2024.362994.1585
Shabani, Alireza, Zaefizadeh, Mohammad, Farhadpour, Mohsen, Soheila Soheili, Zahra, Esfahani, Kasra. β-cyclocitral Extracted from Galium mite (medicinal herb) and the Evaluation of its Effect in MCF-7 Cell Lines. سامانه مدیریت نشریات علمی, 1403; 13(4): 1072-1078. doi: 10.22034/jmpb.2024.362994.1585

β-cyclocitral Extracted from Galium mite (medicinal herb) and the Evaluation of its Effect in MCF-7 Cell Lines

Journal of Medicinal plants and By-Products
مقاله 17، دوره 13، شماره 4، اسفند 2024، صفحه 1072-1078    اصل مقاله (1.28 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.362994.1585
نویسندگان
Alireza Shabani* 1؛ Mohammad Zaefizadeh2؛ Mohsen Farhadpour1؛ Zahra Soheila Soheili1؛ Kasra Esfahani1
1Department of Plant Molecular Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
2Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran
چکیده
Carotenoids play important role as antioxidant and induction of gene expression changes lead to plants acclimation to environmental stresses. Βetacyclocitral (BCC) derived from Galium mite Boiss. & Hohen. in the process of β-carotene oxidation has recently proved that has a new function in breast cancer treatment. In this project we used drug loaded delivery released system (DDRS) strategy, coupled with super paramagnetite nanoparticles (SNPs) based on graphene quantum dots (GQDs) synthesis to deliver drugs to tumor sites. The validation of synthesized SNPs was implemented with several techniques such as Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscope (TEM). MCF-7 cell lines were treated with GQD, β-cyclocitral and GQD@β-cyclocitral (each with concentration of 3.93, 7.87, 15.75, 31.25, 62.5, 125, 250, 500, and 1000 µg/ml) in MTT assay in 24 and 48 hours respectively. IC50% was calculated in 24 h.  Results indicated that β-cyclocitral had prominent effects in breast cancer cell lines controlling.
کلیدواژه‌ها
β-cyclocitral؛ Breast cancer؛ Nano-encapsuulate؛ Graphene quantum dot (GQD)؛ Drug delivery
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