| تعداد نشریات | 286 |
| تعداد نشریات سازمان | 84 |
| تعداد شماره‌ها | 2,829 |
| تعداد مقالات | 32,098 |
| تعداد مشاهده مقاله | 40,864,085 |
| تعداد دریافت فایل اصل مقاله | 18,113,701 |
تأثیر اسانس و عصاره هیدروالکلی زیره سیاه (Carum carvi L.) روی پارامترهای استرس اکسیداتیو در رت‌های مبتلا به التهاب حاد ریوی قبل و بعد از پرتودهی گاما | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 2، دوره 25، شماره 4 - شماره پیاپی 46، بهمن 1388، صفحه 441-455 اصل مقاله (320.48 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2010.6993 | ||
| نویسندگان | ||
| فائزه فاطمی1؛ عبدالامیر علامه2؛ حسین خلفی* 3؛ محمدباقر رضایی4؛ مرضیه سیحون5 | ||
| 1دانشجوی دوره دکترای بیوشیمی بالینی، گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه تربیت مدرس | ||
| 2استاد، گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه تربیت مدرس | ||
| 3دانشیار، پژوهشکده کاربرد پرتوها، پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی | ||
| 4استاد، بخش تحقیقات گیاهان دارویی و محصولات فرعی، مؤسسه تحقیقات جنگلها و مراتع کشور | ||
| 5کارشناس، پژوهشکده کاربرد پرتوها، پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی | ||
| چکیده | ||
| التهاب حاد ریوی یکی از عوارض مزمن سپسیس است که در نهایت منجر به مرگ بیماران مبتلا به سپسیس می‌شود. با توجه به عوارض مصرف داروهای ضد التهابی، استفاده از گیاهان دارویی نظیر زیره سیاه (Carum carvi L.) به منظور کاهش آسیبهای ناشی از سپسیس، مورد توجه می‌باشد. در این تحقیق اثر حفاظتی اسانس و عصاره هیدروالکلی زیره سیاه در جلوگیری از آسیب ریوی در مدل تجربی التهاب حاد (CLP= Cecal Ligation and Puncture) در رت بررسی شده است و در این راستا، تأثیر این دو عصاره بر پارامترهای استرس اکسیداتیو ازجمله آنزیم میلوپراکسیداز، پراکسیداسیون لیپیدها و گلوتاتیون در بافت ریه رتها در گروههای مختلف بررسی شد. همچنین به منظور بررسی تأثیر پرتودهی گاما بر روی خواص دارویی مواد مؤثره زیره سیاه، 4 گروه از رتها با عصاره‌های بدست آمده از زیره سیاه پرتودیده، تیمار و پارامترهای فوق در بافت ریه آنها مورد بررسی قرار گرفت. نتایج حاصل از این تحقیق نشان داد که فقط اسانس زیره سیاه، باعث تعدیل پارامترهای دخیل در استرس اکسیداتیو در مدل CLP شده است و عصاره هیدروالکلی هیچ‌گونه تأثیری بر روی عوامل فوق نداشته است. پرتودهی زیره سیاه در دوز مجاز (10 کیلوگری) و دوز استریل (25 کیلوگری) نیز هیچ‌گونه تأثیری بر روی خواص عصاره‌های استخراج شده از دانه‌های زیره سیاه نمی‌گذارد، به‌طوری که تأثیر اسانس و عصاره هیدروالکلی حاصل از زیره پرتودیده در تعدیل پارامترهای دخیل در استرس اکسیداتیو همانند زیره پرتوندیده است. به‌طور کلی نتایج این تحقیق نشان می‌دهد که اسانس زیره سیاه قادر است عوارض ناشی از التهاب حاد ریوی را کاهش دهد و پرتودهی زیره به منظور افزایش مدت نگهداری این گیاه دارویی نیز هیچ‌گونه تأثیری در خواص آن ندارد. | ||
| کلیدواژه‌ها | ||
| پرتو گاما؛ زیره سیاه (Carum carvi L.)؛ استرس اکسیداتیو؛ التهاب حاد؛ آسیب ریوی؛ رت | ||
| عنوان مقاله [English] | ||
| The effect of essential oils and hydroalcoholic extract of caraway seed on oxidative stress parameters in rats suffering from acute lung inflammation before and after γ-irradiation | ||
| نویسندگان [English] | ||
| F. Fatemi1؛ A. Allameh2؛ H. Khalafi3؛ M.B. Rezaei4؛ M. Seyhoon5 | ||
| 1Department of Clinical Biochemistry, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran | ||
| 2Department of Clinical Biochemistry, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran | ||
| 3Radiation Application Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran | ||
| 4Department of Medicinal Plants, Research Institute of Forests and Rangelands, Tehran, Iran | ||
| 5Radiation Application Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran | ||
| چکیده [English] | ||
| Acute lung inflammation is one of the chronic consequences of sepsis which leads to septic patients death. In consider to the side effects of using anti-inflammatory drugs, herbal drugs such as caraway seed has a great potential application with the aim of treating or/and decreasing the consequences of sepsis. In this study, CLP rat model was used to consider the protective role of hydroalcoholic extract and essential oils derived from caraway seeds in preventing tissue lung injury. In this regards, the effects of caraway extracts on lung oxidative stress parameters i.e. myeloperoxidase, lipid peroxidation and glutathione in different groups of rats were considered. Furthermore, in order to consider the effects of γ-irradiation on pharmacological properties of caraway extracts, four groups of rats treated with irradiated caraway seed extracts and the lung tissues were analyzed using oxidative stress parameters. The results of this study showed that caraway essential oils could modulate the oxidative stress parameters in this experimental acute inflammation; whereas, hydroalcoholic extract did not have any effects on these factors. γ-irradiation of caraway seeds at 10 and 25 kGy also had no effect on these properties of caraway extracts, so that essential oils but not hydroalcoholic extract derived from irradiated caraway seeds could amend oxidative parameters. The results of this study indicated that caraway essential oils could affect the consequences of acute lung injury and also preservation of caraway seeds by irradiation doesn't change its effects. | ||
| کلیدواژه‌ها [English] | ||
| γ-irradiation, caraway, oxidative stress, acute inflammation, lung injury, rat | ||
| مراجع | ||
|
- Adam, B., Liebregts, T., Best, J., Bechmann, L., Lackner, C., Neumann, J., Koehler, S. and Holtmann, G., 2006. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model. Scandinavian Journal of Gastroenterology, 41(2): 155-160. - Alitonou, G.A., Avlessi, F., Sohounhloue, D.K., Agnaniet, H., Bessiere, J.M. and Menut, C., 2006. Investigations on the essential oil of Cymbopogon giganteus from Benin for its potential use as an anti-inflammatory agent. The International Journal of Aromatherapy, 16: 37-41. - Bailer, J., Aichinger, T., Hackl, G., Hueber, K.D. and Dachler, M., 2001. Essential oil content and composition in commercially available dill cultivars in comparison to caraway. Industrial Crops and Products, 14: 229-239. - Banerjee, M. and Sarkar, K.P, 2003. Microbiological quality of some retail spices in India. Food Research International, 36: 469-474. - Benjamim, C.F., Hogaboam, C.M. and Kunkel, S.L., 2004. The chronic consequences of severe sepsis. Journal of leukocyte biology, 75: 408-412. - Bone, R.C., Grodzin, C.J. and Balk, R.A., 1997. Sepsis: A new hypothesis for pathogenesis of the disease process. Chest, 112: 235-243. - Buege, J.A. and Aust, S.D., 1978. Microsomal lipid peroxidation. In: Packer, L., (ed), Methods in Enzymology. Academic Press: New Jersey; 52: 302-310. - Chaudry, I.H., Hirasawa, H. and Baue, A.E., 1980. Effect of adenosine triphosphate-glucose administration following sepsis. Journal of Surgical Research, 29: 348–356. - Cherian, S., Jameson, S., Rajarajeswari, C., Helena, V., Lakshmi Latha, L., Rekha, M.R.A., Nagamma, T., Raju, V.S., Kini, P.G. and Rao, A., 2007. Oxidative stress in sepsis in children. Indian Journal of Medical Research, 125: 143-148. - Crowell, P.L., Lin, S., Vedejs, E. and Gould, M.N., 1992. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth, Cancer Chemotherapy and Pharmacology, 31: 205-212. - De Carvalho, C.C.C.R. and Da Fonseca, M.M.R., 2006. Carvone: Why and how should one bother to produce this terpene, Food Chemistry, 95: 413-422. - Demirbilek, S., Sizanli, E., Karadag, N., Karaman, A., Bayraktar, N., Turkmen, E. and Ersoy, M.O., 2006. The effects of methylene blue on lung injury in septic rats. European Surgical Research, 38(1):35-41. - Eddouks, M., Lemhadri, A. and Michel, J.B., 2004. Caraway and caper: Potential anti-hyperglycaemic plants in diabetic rats. Journal of Ethnopharmacology, 94: 143-148. - Esmon, C.T., 2004. Why do animal models (sometimes) fail to mimic human sepsis?. Critical Care Medicine, 32: S219-S222. - Evenhuis, A., Verdam, B., Gerlagh, M. and Goossen-van de Geijn, H.M., 1995. Studies on major diseases of caraway (Carum carvi) in the Netherlands. Industrial Crops and Products, 4: 53-61. - Griffin, S.G., Wyllie, G., Markham, J.L. and Leach, D.N., 1999. The role of structure and molecular properties of terpenoids in determining their antimicrobial activity, Flavour and Fragrance Journal, 14: 322-332. - Gürer, A., Ozdoğan, M., Gökakin, A.K., Gömceli, I., Gülbahar, O., Arikök, A.T., Kulaçoğlu, H. and Aydin, R., 2009. Tissue oxidative stress level and remote organ injury in two-hit trauma model of sequential burn injury and peritoneal sepsis are attenuated with N-acetylcysteine treatment in rats. Ulusal Travma Ve Acil Cerrahi Dergisi, 15(1): 1-6. - Hillegass, L.M., Griswold, D.E., Brickson, B. and Albrightson-Winslow, C., 1990. Assessment of myeloperoxidase activity in whole rat kidney. Journal of Pharmacology Methods, 24: 285-295. - Hongratanaworakit, T. and Buchbauer, G., 2006. Relaxing effect of ylang ylang oil on humans after transdermal absorption. Phytotherapy Research, 20: 758-763. - Hubbard, W.J., Choudhry, M., Schwacha, M.G. and Kerby, J.D., 2005. Cecal ligation and puncture, Shock, 24: 52-57. - Janssen, A.M., Scheffer, J.J.C. and Svendsen, A.B., 1987. Antimicrobial activity of essential oils: a 1976-1986 literature review, Aspects of the test methods. Planta Medica, 5: 395-398. - Keller, S.A., Paxian, M., Lee, S.M., Clemens, M.G. and Huynh, T., 1993. Kupffer Cell Ablation Attenuates Cyclooxygenase-2 Expression after Trauma and Sepsis. Journal of Surgical Research, 124: 126-133. - Khayyal, M.T., Seif-El-Nasr, M., El-Ghazaly, M.A., Okpanyi, S.N., Kelber, O. and Weiser, D., 2006. Mechanism involved in gastro-protective effect of STW5 (Iberogast ((R))) and its components against ulcers and rebound acidity, Phytomedicine, 13: 56-66. - Koseki, P.M., Villavicencio, A.L.C.H., Brito, M.S., Nahme, L.C., Katia, I.S., Relaa, P.R., Almeida-Muradianb, L.B., Mancini-Filhob, J. and Freitas, P.C.D., 2002. Effects of irradiation in medicinal and eatable herbs. Radiation Physics and Chemistry, 63: 681-684. - Liaw, W.J., Chen, T.H., Lai, Z.Z., Chen, S.J., Chen, A., Tzao, C., Wu, J.Y. and Wu, C.C., 2005. Effects of a membrane-permeable radical scavenger, Tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock, 23(1): 88-96. - Mahindru, S.N., 2005. Food Preservation and Irradiation. Saujanya, New Delhi, 231p. - Marshall, J.C., Vincent, J.L., Fink, M.P., Cook, D.J., Rubenfeld, G., Foster, D., Fisher, J.R., Faist, E. and Reinhart, K., 2003. Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable. Critical Care Medicine, 31: 1560-1567. - Matsumura, T., Ishikawa, T. and Kitajima, J., 2002. Water-Soluble Constituents of Caraway: aromatic compound, aromatic compound glucoside and glucides. Phytochemistry, 61: 455-459. - Nencini, C., Giorgi, G. and Micheli, L., 2007. Protective effect of silymarine stress in rat brain. Phytomedicine, 14: 129-135. - Ozdulger, A., Cinel, I., Koksel, O., Cinel, L., Avlan, D., Unlu, A., Okcu, H., Dikmengil, M. and Oral, U., 2003. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock, 19(4): 366-372. - Ozturk, E., Demirbilek, S., Begec, Z., Surucu, M., Fadillioglu, E., Kirimlioglu, H. and Ersoy, M.O., 2008. Does leflunomide attenuate the sepsis-induced acute lung injury?. Pediatric Surgery International, 24(8): 899-905. - Podrez, E.A., Abu-Soud, H.M. and Hazen, S.L., 2000. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radical Biology & Medicine, 28: 1717-1725. - Presterl, E., Staudinger, T., Pettermann, M., Lassnigg, A., Burgmann, H., Winkler, S., Frass, M. and Graninger, W., 1997. Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis. American Journal of Respiratory and Critical Care Medicine, 156: 825-832. - Rasooli, I., Fakoor, M.H., Yadegarinia, D., Gachkar, L., Allameh, A. and Rezaei, M.B., 2008. Antimycotoxigenic characteristics of Rosmarinus officinalis and Trachyspermum copticum L. essential oils. International Journal of Food Microbiology, 122: 135-139. - Rasooli, I., Rezaei, M.B. and Allameh, A., 2006. Ultrastructural studies on antimicrobial efficacy of thyme essential oils on Listeria monocytogenes. International Journal of Infectious Disease, 10(3): 236-241. - Rios, J.L., Recio, M.C. and Villar, A., 1988. Screening methods for natural products with antimicrobial activity: a review of the literature. Journal of ethnopharmacology, 23: 127–149. - Satyanarayana, S., Sushruta, K., Sarma, G.S., Srinivas, N. and Subba Raju, G.V., 2004. Antioxidant activity of the aqueous extracts of spicy food additives--evaluation and comparison with ascorbic acid in in-vitro systems. Journal of Herbal Pharmacotherapy, 4(2): 1-10. - Sedlak, J. and Lindsay, R.H., 1968. Estimation of total protein with bound and non-protein sulfhydryl groups in tissues with Ellman’s reagent. Analytical Biochemistry, 25: 192–205. - Sharma, R.A., Dalgleish, A.G., Steward, W.P. and O'byrne, K.J., 2003. Angiogenesis and the immune response as targets for the prevention and treatment of colorectal cancer (Review). Oncology Reports, 10: 1625-1631. - Toklu, H.Z., Tunali Akbay, T., Velioglu-Ogunc, A., Ercan, F., Gedik, N., Keyer-Uysal, M. and Sener, G., 2008. Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. The Journal of Surgical Research, 145(2): 214-222. - Villa, P., Saccani, A. and Sica, A., 2002. Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. The Journal of Infectious Diseases, 185: 1115–1120. - Wu, J.Y., Tsou, M.Y., Chen, T.H., Chen, S.J., Tsao, C.M. and Wu, C.C., 2008. Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. Journal of Pineal Research, 45(1):106-116. - Yang, C.S., Sang, S., Lambert, J.D. and Lee, M.J., 2008. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Molecular Nutrition and Food Research, 52: 139-151. | ||
|
آمار تعداد مشاهده مقاله: 2,256 تعداد دریافت فایل اصل مقاله: 1,219 |
||