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The effect of niosome nanosystem containing Satureja khuzistanica extract on antioxidant and antimicrobial properties | ||||||
| Journal of Organic Farming of Medicinal Plants | ||||||
| دوره 3، شماره 2 - شماره پیاپی 2980، شهریور 2024، صفحه 59-71 اصل مقاله (774.01 K) | ||||||
| نوع مقاله: Original Article | ||||||
| نویسندگان | ||||||
| Mirabolghasem Miri1؛ Fahimeh Najafi* 2؛ Ali Asghar Bagheri Keshtali3 | ||||||
| 11Master's student, Department of Chemistry, Ro.C., Islamic Azad University, Roudehen, Iran. | ||||||
| 2Department of Chemistry, Ro.C., Islamic Azad University, Roudehen, Iran | ||||||
| 33Department of biology, Ro.C., Islamic Azad University, Roudehen, Iran | ||||||
| چکیده | ||||||
| Background and Objective: design and development of novel drug delivery systems has been considered as an effective strategy to improve efficacy of drugs and reduce their toxicity in target tissue. In this regard, niosomes as nanoparticle carriers with unique properties such as biodegradability, non-toxicity, and targeted drug delivery capability have been proposed as a promising option. The aim of this study is to investigate antimicrobial and antioxidant effects of niosomes containing Satureja khuzistanica extract on microbial pathogens and cancer cells. Materials and Methods: In this study, niosomes were first prepared by thin-layer hydration method, then properties of nanoparticles were determined by SEM. The amount of drug release was measured with a dialysis bag. Drug release was evaluated dynamically and finally antimicrobial activity of the niosomal Nano system of Satureja khuzistanica extract was determined using MIC and MBC in comparison with its free form. Antioxidant activity was determined by two methods, DPPH and ABTS, for niosomal Nano system form in comparison with free form. Results: results showed that synthesized nanoparticles had a spherical structure and aggregation and agglomeration were observed in some places. Cumulative release of extract in PBS-SDS medium showed that over 72 hours, the rate of extract release from niosomes was less than its free form; so that over 48 and 72 hours, 54% and 56% of extract was released from niosomal Nano carriers, respectively. Also, evaluation of antioxidant activity in both methods for niosomal Nano carriers containing extract has a higher recovery percentage than free extracts. Conclusion: Niosomes prepared from Satureja khuzistanica show property of inhibiting and controlling microbial and anticancer activity and can be used as an effective drug delivery system in treatment of microbial infections and cancer. These findings can be basis for future research in field of developing natural medicines and new drug delivery systems | ||||||
| کلیدواژهها | ||||||
| antibacterial؛ controlled release؛ extract؛ niosomes؛ antioxidant؛ targeted drug delivery | ||||||
| مراجع | ||||||
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