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Therapeutic effect of exosomes derived from bone marrow mesenchymal stem cells on the lingual papillae mucositis induced by 5-Fluorouracil in albino rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 آذر 1404 اصل مقاله (1.31 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.371048.3900 | ||
| نویسندگان | ||
| Sara Mostafa Shogaa* 1؛ Enas Mahmoud Hegazy2؛ Mahmoud Mohamed Al Ankily3؛ Rania Abdelazeim Galhom4؛ Elham Fathy Mahmoud5 | ||
| 1Department of oral biology, Faculty of Dentistry, The British University in Egypt, El Sherouk city, Suez road, Cairo, Egypt | ||
| 2Department of oral biology, Faculty of dentistry, Suez Canal University, Ismailia, Egypt | ||
| 3Department of Oral Biology, Faculty of Dentistry, The British University in Egypt, El Sherouk city, Suez road, Cairo, Egypt | ||
| 4Department of Human Anatomy and Embryology , Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| 5Department of Oral Biology, Faculty of dentistry, Suez Canal University, Ismailia, Egypt | ||
| چکیده | ||
| Fluorouracil (5-FU) is one of the prevalent anti-cancer drugs that is commonly used into chemotherapeutic modalities to treat head and neck solid cancers. However, various studies have reported that 5-FU has the ability to generate toxicity in different tissues causing oral mucositis. Using exosomes derived from stem cells is gaining a huge attention for therapies as it may have certain advantages over adult stem cell-based therapies. This study aimed to evaluate the therapeutic effect of bone marrow stem cells derived exosomes on the cytotoxicity induced by 5-Fluorouracil on the lingual papillae of the albino rats. Thirty male Albino rats weighing between 150 - 200 grams were equally and randomly divided into 3 groups as follows: Group I (control group): containing 10 rats, received saline daily via oral gavage for 14 days. Group II (5-FU group): containing 10 rats, received a single IP injection of 5-FU® drug (50 mg/kg) each. Group III (5-FU + Exosomes group): containing 10 rats, the rats was treated as group II, then injected by a single injection through the tail vein of exosomes on day 2 (100 μg/kg/dose suspended in 0.2 ml PBS). Rats of each group were euthanized after 14 days, and tongue specimens were collected for histological, ultrastructural and immunohistochemical evaluation. In 5-FU treated group, there were marked degenerative changes of the filiform such as areas of keratin separation and hyperkeratinization and the fungiform papillae showed atrophy and deformed taste buds. While the Exosomes treated group showed marked improvement in the histological, ultrastructural and immunohistochemical results. Exosomes derived from bone marrow mesenchymal stem cells exerted an obvious therapeutic effect against the induced mucositis caused by the cytotoxic effect of 5-flourouracil represented by improved histological, ultrastructural and immunohistochemical results. | ||
| کلیدواژهها | ||
| 5-Fluorouracil؛ BAX؛ Exosomes؛ Mesenchymal Stem Cells derived Exosomes؛ Oral Mucositis | ||
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