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Echium Amoenum Hydroalcoholic Extract Effect on Oxidative Stress due to Heat Stress in Rats | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 25 تیر 1404 اصل مقاله (614.72 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368747.1910 | ||
| نویسندگان | ||
| Ameneh Khoshvaghti* 1؛ Zahra Panahi2؛ Jafar Rahmani Kahnamoei2 | ||
| 1Department of Clinical Sciences, Kaz.C., Islamic Azad University, Kazerun, Iran | ||
| 2Department of Biochemistry, Agriculture and New Technologies, Shiraz Branch, Islamic Azad University, Shiraz, Iran | ||
| چکیده | ||
| Among the biggest problems facing the world today are climate change and heat stress in the environment. It is crucial to look into these effects on various organisms. One of the most critical consequences of global warming is heat stress, which significantly disrupts the oxidative balance in living organisms by increasing reactive oxygen species (ROS) and reducing antioxidant capacity. This imbalance leads to cellular and tissue damage. Therefore, identifying effective strategies to reduce oxidative damage caused by heat stress is essential. One of the top priorities is to eradicate heat stress in living things. Plant extracts can significantly reduce heat stress by enhancing the immune system, improving effectiveness, and having few side effects. Residual medicinal plant extracts, such as Echium amoenum, are known for their antioxidant properties. In this study, the protective effect of Echium amoenum hydroalcoholic extract on oxidative stress induced by acute and chronic heat exposure in rats was investigated. Six groups of sixty rats were prepared. These groups include healthy control, sham, acute and chronic heat stress control stress groups (groups T1 and T2), group T3: chronic heat stress conditions with daily injection of 400 mg/kg body weight of the extract for 21 days, and group T4: acute heat stress conditions with daily injection of 400 mg/kg body weight of the extract for 21 days. Blood was taken from the rats under sterile conditions at the end of the study. The investigated parameters were measured using conventional techniques in the resultant sera. The findings demonstrated that prolonged exposure to heat significantly lowers serum catalase. All of the indicators that were examined catalase, vitamin D, superoxide dismutase, glutathione peroxidase, malondialdehyde, and total antioxidant capacity showed a noteworthy variation in response to acute heat stress in comparison to the control group. However, following the extract injection, a comparison of two heat stress groups and the control group demonstrated the extract's beneficial effects on stress reduction. In conclusion, the findings of this study showed that treatment with Echium amoenum notably improves oxidative markers, especially under acute heat stress. This extract can alleviate oxidative damage caused by heat stress in rats. | ||
| کلیدواژهها | ||
| Echium amoenum flower؛ Heat stress؛ Hydroalcoholic extract؛ Rat | ||
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