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Hamza Taha, Hawler, N. Adham, Aveen. (1404). Phytochemical Analysis and Assessment of Antioxidant and Anti-Gastric Ulcer Effects of Prosopis farcta in an Ethanol-Induced Ulcer Model. سامانه مدیریت نشریات علمی, 15(1), 27-35. doi: 10.22034/jmpb.2025.369324.1955
Hawler Hamza Taha; Aveen N. Adham. "Phytochemical Analysis and Assessment of Antioxidant and Anti-Gastric Ulcer Effects of Prosopis farcta in an Ethanol-Induced Ulcer Model". سامانه مدیریت نشریات علمی, 15, 1, 1404, 27-35. doi: 10.22034/jmpb.2025.369324.1955
Hamza Taha, Hawler, N. Adham, Aveen. (1404). 'Phytochemical Analysis and Assessment of Antioxidant and Anti-Gastric Ulcer Effects of Prosopis farcta in an Ethanol-Induced Ulcer Model', سامانه مدیریت نشریات علمی, 15(1), pp. 27-35. doi: 10.22034/jmpb.2025.369324.1955
Hamza Taha, Hawler, N. Adham, Aveen. Phytochemical Analysis and Assessment of Antioxidant and Anti-Gastric Ulcer Effects of Prosopis farcta in an Ethanol-Induced Ulcer Model. سامانه مدیریت نشریات علمی, 1404; 15(1): 27-35. doi: 10.22034/jmpb.2025.369324.1955

Phytochemical Analysis and Assessment of Antioxidant and Anti-Gastric Ulcer Effects of Prosopis farcta in an Ethanol-Induced Ulcer Model

Journal of Medicinal plants and By-products
مقاله 4، دوره 15، شماره 1، فروردین و اردیبهشت 2026، صفحه 27-35    اصل مقاله (1.49 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369324.1955
نویسندگان
Hawler Hamza Taha* ؛ Aveen N. Adham
Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq
چکیده
Peptic ulcer disease (PUD) is a common digestive tract disorder with a global impact. Conventional treatments such as Pods of Prosopis farcta (Banks & Sol.) J.F.Macbr.are widely used by Kurdistan residents. This study aimed to evaluate the antiulcer efficacy of its fruit pod extract in an ethanol-induced gastric ulcer model in rats. The low extract yield was obtained by ultrasonic-assisted extraction using 80% ethanol. Phytochemical analysis identified alkaloids, flavonoids, saponins, tannins, terpenoids, and cardiac glycosides. The low extract yield was obtained by ultrasonic-assisted extraction using 80% ethanol. The quantitative analysis identified a rich phenolic content (40.80 ± 0.78 µg/mg), tannins (31.59 ± 0.55 µg/mg), and flavonoids (8.52 ± 1.18 µg/mg). The extract had adequate antioxidant activity (IC₅₀ = 74.94 ± 0.22µg/ml). HPLC analysis validated ten phenolic compounds, with caffeic acid (114.8 µg/ml), kaempferol (92.6 µg/ml), and catechin (81.4 µg/ml) being the most abundant. The acute toxicity evaluation demonstrated no toxic effects at doses up to 2000 mg/kg. In vivo, animal studies also revealed good antiulcer activity at both low (250 mg/kg) and high (500 mg/kg) doses paralleled the effectiveness of esomeprazole, with comparable improvements in ulcer healing parameters. Treatment resulted in measurable gastroprotective effects, increased intragastric pH, and reduced overall acidity parameters. Safety assessments also showed no harmful effects on the liver and kidney functions or the lipid profiles. Hence, the present study advocates that P. farcta fruit pod extract is a safe and efficient natural product for managing peptic ulcers.
کلیدواژه‌ها
Anti-gastric ulcer؛ DPPH assay؛ HPLC؛ Inflammatory biomarkers؛ Prosopis farcta
مراجع
  1. Sadiq K., Rizwan B., Noreen S., Fatima A., Sheraz M., Shafqat M., Rashid HM. Determinants of peptic ulcer disease: A systematic review. EAS Journal of Nutrition and Food Sciences. 2020;2:257–264.
  2. Lauret M., Pérez I., Rodrigo L. Peptic ulcer disease. Austin Journal of Gastroenterology. 2015;2:1055–1063.
  3. Carrasco V., Pinto LA., Cordeiro KW., Cardoso C.A., de Cássia Freitas K. Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sessé ex DC. (balsam). Journal of Ethnopharmacology. 2014;158:345–351.
  4. Srinivas T.L., Lakshmi S.M., Shama S.N., Reddy G.K., Prasanna K.R. Medicinal plants as anti-ulcer agents. Journal of Pharmacognosy and Phytochemistry. 2013;2:91–97.
  5. Eroglu T.E., Coronel R., Gislason G.H. Use of proton pump inhibitors is associated with increased risk of out-of-hospital cardiac arrest in the general population: a nested case-control study. Eur. Hear. Journal-Cardiovascular Pharmacother. 2024;10:413–419.
  6. Lam J..R., Schneider JL., Zhao W., Corley D.A. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. Jama. 2013;310:2435–2442.
  7. Arefpour H., Sadeghi A., Zayeri F., Hekmatdoost A. The application of ginger supplementation on peptic ulcer disease management: A randomized, double blind, placebo-controlled clinical trial. Clinical Nutrition Open Science. 2024;57:231–240.
  8. Ghaliaoui N., Hazzit M., Mokrane H. Seaweeds as a potential source of bioactive compounds. Research in Biotechnology and Environmental Science. 2024;3:1–8.
  9. Qasemi A., Bayat Z., Akbari N., Babazadeh D. Bacterial resistance of acinetobacter baumannii: A global concern. Research in Biotechnology and Environmental Science. 2022;1:36–42.
  10. Kaur D., Rana AC., Sharma N., Kumar S. Herbal drugs with anti ulcer activity. Journal of Applied Pharmaceutical Science. 2012;160–165.
  11. Eslammanesh T., Rezaei M., Dahmardeh N., Anoosha A. Investigation of the Antimicrobial Activity of Nine Medicinal Plants on Standard Bacteria. Research in Biotechnology and Environmental Science. 2024;3:29–38.
  12. Zhong J., Lu P., Wu H., Liu Z., Sharifi-Rad J., Setzer WN., Suleria HA. Current insights into phytochemistry, nutritional, and pharmacological properties of Prosopis plants. Evidence-Based Complementary and Alternative Medicine. 2022;2022:2218029.
  13. AL-WAHEEB AN. Chemical composition of Prosopis farcta (Banks & Soland) Macbride (Leguminoseae or Fabaceae) fruits. Iranian Journal of Ichthyology. 2021;8:120–126.
  14. Al-Aboudi A., Afifi FU. Plants used for the treatment of diabetes in Jordan: A review of scientific evidence. Pharmaceutical Biology. 2011;49:221–239.
  15. Miri A., Khatami M., Ebrahimy O., Sarani M. Cytotoxic and antifungal studies of biosynthesized zinc oxide nanoparticles using extract of Prosopis farcta fruit. Green Chem. Review Letters. 2020;13:27–33.
  16. Al-Qura S. Taxonomical and Pharmacological Survey of Therapeutic Plants in Jordan. Journal of Natural Products. 2008;1:10–26.
  17. Asadollahi A., Sarir H., Omidi A., Torbati MB. Hepatoprotective potential of prosopis farcta beans extracts against acetaminophen-induced hepatotoxicity in wister rats. International Journal of Preventive Medicine. 2014;5:1281–1285.
  18. Noroozi R., Sadeghi E., Yousefi H., Taheri M., Sarabi P., Dowati A., Ayatallahi SA., Noroozi R., Ghafouri-Fard S. Wound healing features of Prosopis farcta: in vitro evaluation of antibacterial, antioxidant, proliferative and angiogenic properties. Gene Reports. 2019;17:100482.
  19. Ahmed K.M., Mahmud S.A. Curative Effects of Ethanol Extract of Prosopis Farcta (Syrian Mesquite) Against Ethylene Glycol Induced Urolithiasis in Male Albino Rats. Science Journal of University of Zakho. 2021;9:89–96.
  20. Mollashahi M., Tehranipour M., Khayyatzade J., Moosavi BZ. The neuroprotective effects of Prosopis farcta pod aqueous and ethanol extracts on spinal cord α-motoneurons neuronal density after sciatic nerve injury in rats. Life Science Journal. 2013;10:293–297.
  21. Saidi M.R., Farzaei M.H., Miraghaee S., Babaei A., Mohammadi B., Bahrami MT., Bahrami G. Antihyperlipidemic Effect of Syrian Mesquite (Prosopis farcta) Root in High Cholesterol Diet–Fed Rabbits. Journal Evidence-based Complementary and Alternative Medicine. 2016;21:NP62–NP66.
  22. Heydari M., Sarir H., Ghiasi S.E., Farhangfar H. Effects of Prosopis farcta fruit Hydroalcoholic Extract on Serum Concentrations of Glucose and Lipids in Insulin Resistance Model of Rats. Zahedan Journal of Research in Medical Sciences. 2018;20:e13498.
  23. Kobarfard F., Ayatollahi S.A., Khosravi-Dehaghi N., Faizi M., Amidi S., Martorell M., Choudhary MI., Suleria HA., Sharifi-Rad J. High-performance thin-layer chromatography fingerprinting, total phenolic and total flavonoid contents and anti-platelet-aggregation activities of Prosopis farcta extracts. Cellular and Molecular Biology. 2020;66:8–14.
  24. Amal M.S., Mosad A.G., Mohamed S.A-A., Madkour H.M., Khalaf O.M., El-Ziaty A.K., Abdel-Mogib M. Chemical constituents and biological activities of different solvent extracts of Prosopis farcta growing in Egypt. Journal of Pharmacognosy and Phytotherapy. 2017;9:67–76.
  25. Juee L.Y.M., Sofi S.H., Adham A.N. Melissa officinalis gastroprotective and antioxidant efficacy. Journal of Functional Foods. 2023;105:105550.
  26. Hassanshahian M., Bayat Z., Saeidi S., Shiri Y. Antimicrobial activity of Trachyspermum ammi essential oil against human bacterial. International Journal of Advanced Biological and Biomedical Research. 2014;2:18–24.
  27. Dubale S., Kebebe D., Zeynudin A., Abdissa N., Suleman S. Phytochemical Screening and Antimicrobial Activity Evaluation of Selected Medicinal Plants in Ethiopia. Journal of Experimental Pharmacology. 2023;15:51–62.
  28. Oshadie G., Silva D., Abeysundara A.T., Aponso M.M. Extraction methods, qualitative and quantitative techniques for screening of phytochemicals from plants. essencejournal.com GO Silva, Abeysundara, MMW Aponso. American Journal of Essential Oils and Natural Products. 2017;5:29–32.
  29. Vala M., Maitreya B. Qualitative analysis, total phenol content (TPC) and total tannin content (TTC) by using different solvant for flower of Butea monosperma (Lam.) Taub. collected from Saurashtra region. Journal of Pharmacognosy and Phytochemistry. 2019;8:2902–2906.
  30. Chandran K.C., Kavitha Chandran C.C. Quantitative estimation of total phenolic, flavonoids, tannin and chlorophyll content of leaves of Strobilanthes Kunthiana (Neelakurinji). Journal of Medicinal Plants Studies. 2016;4:282–286.
  31. Ngamsuk S., Huang T.C., Hsu J.L. Determination of phenolic compounds, procyanidins, and antioxidant activity in processed coffea Arabica L. leaves. Foods 2019;8:389.
  32. Adham A.N., Sharef A.Y., Ahmad H.O., Abdulla S.S. Evaluation of the antioxidant and anti-ulcer activities of the ethanolic extract of Fumaria officinalis. South African Journal of Botany. 2022;151:816–825.
  33. Maru S., Belemkar S. Acute and Subacute Oral Toxicity Study of a Herbal Formulation Containing Asparagus racemosus, Tinospora cordifolia, and Trigonella foenum-graceum in Mice. Journal of Toxicology. 2025;2025:8221552.
  34. Shams S.G.E., Eissa R.G. Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-κB pathways. Heliyon. 2022;8
  35. Arab H.H., Salama S.A., Omar H.A., Arafa E.S., Maghrabi I.A. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS One. 2015;10:e0122417.
  36. Firehun B., Nedi T. Gastroprotective Activities of Aqueous and 80% Methanol Leaf Extracts of Stephania abyssinica (Quart.-Dill. and A. Rich.) Walp. (Menispermaceae) in Rats. Journal of Experimental Pharmacology. 2023;15:497–512.
  37. Aziz R.S. The Gastroprotective Effect Of Bezafibrate And Ginkgo Biloba In Ethanol-Induced Gastric Ulcer In Rats. Al-Rafidain Journal of Medical Sciences (ISSN 2789-3219) 2025;8:144–149.
  38. Ali M., Jahromi F., Etemadfard H., Zebarjad Z. Antimicrobial and Antioxidant Characteristics of Volatile Components and Ethanolic Fruit Extract of Prosopis farcta (Bank & Soland.). Trends in Pharmacological Sciences. 2018;4:177–186.
  39. Ratananikom K., Premprayoon K. Ultrasonic-Assisted Extraction of Phenolic Compounds, Flavonoids, and Antioxidants from Dill (Anethum graveolens L.). Scientifica (Cairo). 2022;2022:3848261.
  40. Safari A.A., Sharifzadeh M., Hassanzadeh G. The protective effect of a standardized hydroalcoholic extract of Prosopis farcta (Banks & Sol.) J.F.Macbr. Fruit in a rat model for experimental ulcerative colitis. Traditional Medicine Research. 2021;6:40.
  41. Poudineh Z., Amiri R., Najafi S., Mir N. Total phenolic content, antioxidant, and antibacterial activities of seed and pod of Prosopis farcta from Sistan region, Iran. Azarian Journal of Agriculture. 2015;2:51–56.
  42. Mahmud S.O., Amin Z.A., Nuraddin S.M., Alshawsh M.A. Antioxidant And Wound Healing Properties Of Prosopis farcta And Adiantum Capillus Plant Extracts: An In Vitro Study. Journal of Pharmaceutical Negative Results. 2023;14:3831–3839.
  43. Sharifi-Rad J., Kobarfard F., Ata A., Ayatollahi SA., Khosravi-Dehaghi N., Jugran AK., Tomas M., Capanoglu E., Matthews K.R., Popović-Djordjević J., Kostić A. Prosopis plant chemical composition and pharmacological attributes: Targeting clinical studies from preclinical evidence. Biomolecules. 2019;9:777.
  44. Sharifi-Rad J., Zhong J., Ayatollahi SA., Kobarfard F., Faizi M., Khosravi-Dehaghi N., Suleria H.A. LC-ESI-QTOF-MS/MS characterization of phenolic compounds from Prosopis farcta (Banks & Sol.) J.F.Macbr. And their potential antioxidant activities. Cellular and Molecular Biology. 2021;67:189–200.
  45. Karimi E., Aidy A., Abbasi N. Quantitative HPLC Analysis of Phenolic Compounds in Prosopis Farcta from two Different Ecological Zones of Iran. Indian Journal of Chemical Technology (IJCT). 2017;12:116.
  46. Obode O.C., Adebayo AH., Li C. Phytochemical and toxicological evaluations of Prosopis africana (GUILL. and PERR.) extract on albino wistar rats. Toxicology Research. 2021;37:183–195.
  47. Dong J., Yang S., Zhuang Q., Sun J., Wei P., Zhao X., Chen Y., Chen X., Li M., Wei L., Chen C. The Associations of Lipid Profiles With Cardiovascular Diseases and Death in a 10-Year Prospective Cohort Study. Frontiers in Cardiovascular Medicine. 2021;8:745539.
  48. Simões S., Lopes R., Campos M.C.D., Moosavi B.Z. Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation. Animal Models and Experimental Medicine. 2019;2:121–126.
  49. Karampour N.S., Arzi A., Rezaie A., Pashmforoosh M., Kordi F. Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicine. 2019;55:64.
  50. Boligon A.A., Freitas R.B. de., Brum T.F. de., Waczuk E.P., Klimaczewski C.V., de Ávila D.S., Athayde M.L., de Freitas Bauermann L. Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats. Acta Pharmaceutica Sinica B. 2014;4:358–367.
  51. Duan Z., Yu S., Wang S., Deng H., Guo L., Yang H., Xie H. Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition. Nutrients. 2022;14:4744.
  52. Wu Y., Guo Y., Huang T., Huang D., Liu L., Shen C., Jiang C., Wang Z., Chen H., Liang P., Hu Y. Licorice flavonoid alleviates gastric ulcers by producing changes in gut microbiota and promoting mucus cell regeneration. Biomedicine & Pharmacotherapy. 2023;169:115868.
  53. Shahzad N., Ibrahim I.A.A., Alzahrani A.R., Al-Ghamdi S.S., Alanazi I.M., Ahmad M.P., Singh A.K., Alruqi M.A., Shahid I., Equbal A., Azlina M.F. A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer. Journal of Umm Al-Qura University for Applied Sciences. 2024;1–16.
  54. Zhang W., Lian Y., Li Q., Sun L., Chen R., Lai X., Lai Z., Yuan E., Sun S. Preventative and therapeutic potential of flavonoids in peptic ulcers. Molecules. 2020;25:4626.
  55. Zhou D., Yang Q., Tian T., Chang Y., Li Y., Duan L.R., Li H., Wang S.W. Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role. Biomedicine & Pharmacotherapy. 2020;126:110075.
  56. Li Q., Hu X., Xuan Y., Ying J., Fei Y., Rong J., Zhang Y., Zhang J., Liu C., Liu Z. Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO. Acta Biochimica et Biophysica Sinica (Shanghai). 2018;50:246–253.
  57. Kolgazi M., Cilingir S., Yilmaz O., Gemici M., Yazar H., Ozer S., Acikel-Elmas M., Arbak S., Suyen G.G. Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation. Chemico-Biological Interactions. 2021;334:109351.
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