اخبار و اعلانات

 آمار

تعداد نشریات285
تعداد نشریات سازمان83
تعداد شماره‌ها3,139
تعداد مقالات34,918
تعداد مشاهده مقاله50,383,391
تعداد دریافت فایل اصل مقاله90,276,776
Talib Mahdi, Hayder, Al-masoudy, Hassoon N., Dawood Salman, Ahmed, H. Alsafah, Ameer, S. Imran, Faris, A. Alkhanger, Sajad. (1404). Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine. سامانه مدیریت نشریات علمی, 15(1), 126-131. doi: 10.22034/jmpb.2025.369423.1966
Hayder Talib Mahdi; Hassoon N. Al-masoudy; Ahmed Dawood Salman; Ameer H. Alsafah; Faris S. Imran; Sajad A. Alkhanger. "Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine". سامانه مدیریت نشریات علمی, 15, 1, 1404, 126-131. doi: 10.22034/jmpb.2025.369423.1966
Talib Mahdi, Hayder, Al-masoudy, Hassoon N., Dawood Salman, Ahmed, H. Alsafah, Ameer, S. Imran, Faris, A. Alkhanger, Sajad. (1404). 'Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine', سامانه مدیریت نشریات علمی, 15(1), pp. 126-131. doi: 10.22034/jmpb.2025.369423.1966
Talib Mahdi, Hayder, Al-masoudy, Hassoon N., Dawood Salman, Ahmed, H. Alsafah, Ameer, S. Imran, Faris, A. Alkhanger, Sajad. Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine. سامانه مدیریت نشریات علمی, 1404; 15(1): 126-131. doi: 10.22034/jmpb.2025.369423.1966

Effect of Camellia sinensis on Hematological, Hepatic, and Renal Parameters in Rabbits: Implications for Health and Herbal Medicine

Journal of Medicinal plants and By-products
مقاله 17، دوره 15، شماره 1، فروردین و اردیبهشت 2026، صفحه 126-131    اصل مقاله (567.97 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2025.369423.1966
نویسندگان
Hayder Talib Mahdi1؛ Hassoon N. Al-masoudy* 1؛ Ahmed Dawood Salman2؛ Ameer H. Alsafah1؛ Faris S. Imran1؛ Sajad A. Alkhanger1
1College of Veterinary Medicine, University of Kerbala٫ Karbala, 56001, Iraq
2College of medicine, University of Al-Ameed, Karbala, Iraq
چکیده
Green tea (Camellia sinensis (L.) Kuntze) is widely consumed for its purported health benefits, yet its comprehensive effects on hematological, hepatic, and renal functions remain insufficiently characterized in animal models. This study aimed to systematically evaluate the impact of C. sinensis administration on hematological indices, liver enzyme activity, and kidney function in rabbits. Twelve healthy rabbits were randomly assigned to two groups: a control group (standard diet and water) and a treatment group receiving C. sinensis extract. Over a 60-day period, blood samples were collected at baseline and at the end of the study to assess complete blood count, liver enzymes (ALT, AST, ALP), and kidney function markers (urea, creatinine). Statistical analysis was performed using one-way ANOVA and LSD post-hoc tests. C. sinensis administration significantly increased white blood cell (WBC) counts (p< 0.05), while red blood cell (RBC) counts remained unchanged. Notably, hemoglobin concentration and packed cell volume (PCV) were significantly reduced (p< 0.05) in the treatment group. Liver enzymes (ALT, AST) and renal markers (urea, creatinine) were significantly decreased following C. sinensis supplementation, suggesting hepatoprotective and nephroprotective effects. C. sinensis demonstrates a dual effect by enhancing immune cell counts and improving hepatic and renal biomarkers, while potentially impairing erythropoiesis. These findings support its potential as a functional herbal medicine, warranting further mechanistic and clinical investigations.
کلیدواژه‌ها
Camellia sinensis؛ Green tea؛ Hematology؛ Liver function؛ Kidney function؛ Herbal medicine؛ Antioxidants؛ Immunity
مراجع
  1. Pereira C.G., Barreira L., Bijttebier S., Pieters L., Neves V., Rodrigues M.J., Rivas R., Varela J., Custódio L. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis). Journal of Pharmaceutical and biomedical analysis. 2017; 145: 593-603. doi: 10.1016/j.jpba.2017.07.007
  2. Valduga A.T., Gonçalves I.L., Magri E., Delalibera Finzer J.R. Chemistry, pharmacology and new trends in traditional functional and medicinal beverages. Food Research International. 2019; 120: 478-503. doi: 10.1016/j.foodres.2018.10.091
  3. Maixent J.M., Zeil J.M. ABC, a patented innovation in the infusion of teas and herbal plants: enrichment of Camellia sinensis leaves with dry extracts from herbal plants. Cellular and Molecular Biology (Noisy-le-grand). 2019; 65 (4): 76-78. doi:
  4. Krahe J.C., Krahe M.A., Roach P.D. Development of an objective measure of quality and commercial value of Japanese-styled green tea (Camellia L. sinensis): the Quality Index Tool. Journal of Food Science and Technology. 2018; 55 (8): 2926-2934. doi: 10.1007/s13197-018-3210-2
  5. Farhan M. Green Tea Catechins: Nature's Way of Preventing and Treating Cancer. International Journal of Molecular Sciences. 2022; 23 (18). doi: 10.3390/ijms231810713
  6. Kim M.J., Hwang E.S., Kim K.J., Maeng S., Heo H.J., Park J.H., Kim D.O. Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats. Antioxidants (Basel). 2021; 11 (1). doi: 10.3390/antiox11010001
  7. Yu N.H., Pei H., Huang Y.P., Li Y.F. (-)-Epigallocatechin-3-Gallate Inhibits Arsenic-Induced Inflammation and Apoptosis through Suppression of Oxidative Stress in Mice. Cell Physiol Biochem. 2017; 41 (5): 1788-1800. doi: 10.1159/000471911
  8. Caglar H.G., Selek S., Koktasoglu F., Koyuncu I., Demirel M., Sarikaya A., Meydan S. Effect of Camellia sinensis, Hypericum perforatum and Urtica dioica on kidney and liver injury induced by carbon tetrachloride in rats. Cellular and Molecular Biology (Noisy-le-grand). 2019; 65 (5): 79-86. doi:
  9. Lloyd A.J., Martinez-Martin M.J.P., Warren-Walker A., Hitchings M.D., Moron-Garcia O.M., Watson A., Villarreal-Ramos B., Lyons L., Wilson T., Allison G., Beckmann M. Green Tea with Rhubarb Root Reduces Plasma Lipids While Preserving Gut Microbial Stability in a Healthy Human Cohort. Metabolites. 2025; 15 (2). doi: 10.3390/metabo15020139
  10. Alkandahri M.Y., Sadino A., Abriyani E., Hermanto F., Oktoba Z., Sayoeti M.F.W., Sangging P.R.A., Wardani D., Hasan N., Sari S.W., Safitri N.A., Ikhtianingsih W., Safitri S. Evaluation of hepatoprotective and nephroprotective activities of Castanopsis costata extract in rats. Biomedical Reports. 2025; 22 (2): 24. doi: 10.3892/br.2024.1902
  11. He Y., Chen J. Severe iron-deficiency anemia after short-term moderate consumption of green tea in woman: A rare case report. Heliyon. 2024; 10 (17): e36666. doi:10.1016/j.heliyon.2024.e36666
  12. Settakorn K., Kongkarnka S., Chompupoung A., Svasti S., Fucharoen S., Porter J.B., Srichairatanakool S., Koonyosying P. Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice. Frontiers in Physiology. 2022;13: 1053060. doi: 10.3389/fphys.2022.1053060
  13. Zhao G., Wu X., Wang W., Yang C.S., Zhang J. Tea Drinking Alleviates Diabetic Symptoms via Upregulating Renal Water Reabsorption Proteins and Downregulating Renal Gluconeogenic Enzymes in db/db Mice. Molecular Nutrition & Food Research: e2000505. 2020. doi: 10.1002/mnfr.202000505
  14. Marouani N., Chahed A., Hédhili A., Hamdaoui M.H. Both aluminum and polyphenols in green tea decoction (Camellia sinensis) affect iron status and hematological parameters in rats. European Journal of Nutrition. 2007; 46 (8): 453-459. doi: 10.1007/s00394-007-0685-4
  15. Liao H., Ye J., Gao L., Liu Y. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. Biomedicine & Pharmacotherapy. 2021; 133: 110917. doi: 10.1016/j.biopha.2020.110917
  16. Liu Y., Wu J., Hao H. Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma. Frontiers in Immunology. 2024; 15: 1369110. doi: 10.3389/fimmu.2024.1369110
  17. Eidi A., Mortazavi P., Moghadam J.Z., Mardani P.M. Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats. Pharmaceutical Biology. 2015; 53 (7): 1042-1051. doi: 10.3109/13880209.2014.957783
  18. Morzel M., Canon F., Guyot S. Interactions between Salivary Proteins and Dietary Polyphenols: Potential Consequences on Gastrointestinal Digestive Events. Journal of Agricultural and Food Chemistry. 2022; 70 (21): 6317-6327. doi: 10.1021/acs.jafc.2c01183
  19. Kyriacou N.M., Gross A.S., McLachlan A.J. Green Tea Catechins as Perpetrators of Drug Pharmacokinetic Interactions. Clininal Pharmacology Therapeutics. 2025. doi: 10.1002/cpt.3547
  20. El-Beshbishy H.A. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol. 2005; 38 (5): 563-570. doi: 10.5483/bmbrep.2005.38.5.563
  21. Anwar Ibrahim D., Noman Albadani R. Evaluation of the Potential Nephroprotective and Antimicrobial Effect of Camellia sinensis Leaves versus Hibiscus sabdariffa (In Vivo and In Vitro Studies). Adv Pharmacol Science. 2014: 389834. doi: 10.1155/2014/389834
  22. Negah S.S., Ghazavi H., Vafaee F., Rashidi R., Aminian A.R., Forouzanfar F. The Potential Role of Green Tea and its Main Constituent (Epigallocatechin -3-Gallate) in Pain Relief: A Mechanistic Review. Current Drug Discovery Technologies. 2021; 18 (6): e130921189586. doi: 10.2174/1570163817666201229121033
  23. Vargas F., Romecín P., García-Guillén A.I., Wangesteen R., Vargas-Tendero P., Paredes M.D., Atucha N.M., García-Estañ J. Flavonoids in Kidney Health and Disease. Front Physiol. 2018; 9: 394. doi: 10.3389/fphys.2018.00394
  24. Zhang S., Tang S., Liu Y., Xue B., Xie Q., Zhao L., Yuan H. Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders. Front Endocrinol (Lausanne). 2025; 16: 1500336. doi: 10.3389/fendo.2025.1500336
  25. Morlock G.E., Heil J., Inarejos-Garcia A.M., Maeder J. Effect-Directed Profiling of Powdered Tea Extracts for Catechins, Theaflavins, Flavonols and Caffeine. Antioxidants (Basel). 2021; 10 (1). doi: 10.3390/antiox10010117
  26. Tran H.H., Mansoor M., Butt S.R.R., Satnarine T., Ratna P., Sarker A., Ramesh A.S., Munoz C., Jamil D., Mohammed L. Impact of Green Tea Consumption on the Prevalence of Cardiovascular Outcomes: A Systematic Review. Cureus. 2023; 15 (12): e49775. doi: 10.7759/cureus.49775.
آمار
تعداد مشاهده مقاله: 772
تعداد دریافت فایل اصل مقاله: 246


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب