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Green synthesis of Manganese oxide nanoparticles using basil extract for biocompatibility and therapeutic targeting of Metribuzin poisoned heart and lung tissues in Wistar rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 خرداد 1404 اصل مقاله (507.74 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.369006.3602 | ||
| نویسندگان | ||
| islam Boulaares1؛ samir Derouiche* 2؛ sara chetehouna1؛ Janetta Niemann3 | ||
| 1Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life, El-Oued University, El-Oued 39000, El Oued, Algeria | ||
| 2Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life El Oued University, El Oued 39000, El Oued, Algeria. | ||
| 3Department of genetic, Faculty of Agriculture , Poznan University of Life Science, Poznan, Poland | ||
| چکیده | ||
| Manganese oxide nanoparticles have garnered interest for use in a variety of fields, such as biomedical applications including cancer theranostics, and drug delivery. This work aimed to investigate the potential therapeutic and preventative benefits of green-produced MnO NPs made from basil extract against metribuzin-induced oxidative stress, metabolic toxicity, inflammation, and histological changes in the lungs and heart. 18 male albino Wistar rats were divided into three groups (n = 6), which consisted of a control group, a metribuzin-treated group, and a MnO NPs-treated group. The objective of this study was to determine the increase in mass for each organ and to evaluate the oxidative stress status by measuring the levels of SOD, GPx, GSTs, CAT, GSH, and MDA in the lungs and heart tissues. Additionally, the tissue histology of the organs was examined, and various biochemical parameters and inflammation markers were estimated. The MnO NPs' average particle size was determined to be 6.52 ± 0.88 nm with uniformly spherical in shape. Results of the in vivo rats' study showed that treatment with metribuzin induced grow in weight of organs, oxidative stress, biochemical toxicity, inflammation, and histological changes in the lungs and heart, as well as a significant amelioration of MnO NPs against the toxic effects induced by metribuzin by reversing all of the previous parameters. In conclusion, the results of the in vivo investigation showed that rats given metribuzin herbicide suffered from organs weight gain, oxidative stress, biochemical toxicity, inflammation, and histological alterations in their lungs and heart. Additionally, MnO NPs show effective therapeutic and preventive actions against lungs and heart damage caused by metribuzin. | ||
| کلیدواژه‌ها | ||
| MnONPs؛ Metribuzin؛ Oxidative stress؛ Lungs؛ Heart | ||
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آمار تعداد مشاهده مقاله: 186 تعداد دریافت فایل اصل مقاله: 116 |
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