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Meta-Analysis of Bovine Leptospirosis Prevalence in India | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 خرداد 1404 اصل مقاله (815.62 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2025.368239.3504 | ||
| نویسندگان | ||
| Kirubakaran Vinod Kumar1؛ Prajakta Prashant Bokade1؛ Rithu Lakshman2؛ Oviya Deenadayalan3؛ Shashikumar Sowjanyakumari4؛ Akshata Nayak5؛ Archana Pal6؛ Swathi M6؛ Arun Y P1؛ Kuralayanapalya Puttahonnappa Suresh4؛ Chandan Dharmashekar7؛ Chandan Shivamallu7؛ Vinayagamurthy Balamurugan* 8 | ||
| 1WOAH Reference Laboratory for Leptospirosis, Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560 064, Karnataka, India. | ||
| 2Quarry Lane School, Dublin, California, USA | ||
| 3Lambert High School, 805 Nichols Rs, Suwanee, GA 20024, USA | ||
| 4Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560 064, Karnataka, India. | ||
| 5Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560 064, Karnataka, India | ||
| 6WOAH Reference for Leptospirosis, Indian Council of Agricultural Research -National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560 064, Karnataka, India. | ||
| 7Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India. | ||
| 8ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI) | ||
| چکیده | ||
| Leptospirosis is a globally significant and neglected zoonotic disease caused by pathogenic Leptospira spp., affecting a wide range of mammalian hosts including humans, cattle, and buffaloes. In livestock, it leads to considerable economic losses through abortions, stillbirths, reduced fertility, decreased milk production, especially in tropical and subtropical regions where environmental conditions favor bacterial persistence and transmission. Despite its severity, bovine leptospirosis remains underreported in endemic regions such as India. This meta-analysis synthesized data from 46 studies (2001–2021) to estimate the pooled prevalence, epidemiology, and diagnostic challenges of bovine leptospirosis in India. The pooled prevalence was 29% in cattle and 32% in buffaloes. Seropositivity ranged from 50–70% in animals with reproductive disorders to 15–20% in healthy bovines. Coastal states such as Gujarat, Andhra Pradesh, Maharashtra, Tamil Nadu, Kerala, and the Andaman Islands showed the highest prevalence, influenced by favourable ecological conditions. Twenty pathogenic Leptospira serogroups were identified, with dominant serogroups (Sejroe, Icterohaemorrhagiae, Hebdomadis, Pomona etc.), and evidence of temporal shifts in the prevalent serogroups. Significant diagnostic challenges included variability in sample sizes, heterogeneity among studies, and the limited sensitivity of enzyme-linked immunosorbent assay (ELISA) compared to the gold-standard MAT (Microscopic Agglutination Test). These findings underscore the urgent need for enhanced surveillance, incorporation of diverse serogroups into diagnostic panels, and region-specific vaccination strategies. Strengthening molecular diagnostic tools, improving seroepidemiological studies, and implementing targeted control measures are essential to reduce the impact of leptospirosis on livestock productivity and public health in India. This work offers critical insights to inform policy decisions and intervention strategies for effective disease management. | ||
| کلیدواژه‌ها | ||
| Leptospirosis؛ Bovine؛ Epidemiology؛ India؛ Perspectives | ||
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آمار تعداد مشاهده مقاله: 276 تعداد دریافت فایل اصل مقاله: 135 |
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