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Phytoscreening and Isolation of Some Phenolic Compounds from the Iraqi Gundelia tournefortii and Detecting the Antioxidant Activity of its Crude Extract | ||
| Journal of Medicinal plants and By-products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 اردیبهشت 1404 اصل مقاله (1.45 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2025.368339.1873 | ||
| نویسندگان | ||
| Zainab Mizher Razaq1؛ Yessar AbdULHussian Dawood* 1؛ Thukaa Zuhair. Abdul-Jalil2؛ Sabaa. Ali.Mohammad. AL-Fadal1 | ||
| 1Department of Pharmacognosy. College of Pharmacy, University of Basra, Basra, Iraq | ||
| 2Department of Pharmacognosy. College of Pharmacy, University of Baghdad, Baghdad, Iraq | ||
| چکیده | ||
| Herbal medicine is a crucial area of current research, offering numerous benefits and minimal drawbacks. Gundelia tournefortii, because of its high content of bioactive chemicals, can potentially treat several illnesses, especially those involving the antioxidant system. A few studies have dealt with these plants in Iraq. Therefore, this study investigated this plant. In this study, the phenolic compounds were detected using Reverse Phase High-Performance Liquid Chromatography- UltraViolet-Visible (HPLC-UV-Vis) of the methanolic extract obtained from the aerial parts of Iraqi G. tournefortii by Soxhlet extraction and rutin and gallic acid were isolated from the methanol extract by preparative liquid chromatography, the isolated rutin and gallic acid were further characterized by high-performance liquid chromatography, thin layer chromatography, and Fourier Transforms Infrared (FT-IR) spectroscopy, then the antioxidant effectiveness of this extract was evaluated and compared with vitamin C as a standard in five concentrations of 500, 400, 300, 200 and 100 µg/mL using 2,2-Diphenyl-1-Picrylhydrazyl Free Radical Scavenging Assay, which showed a high free radical scavenging activity for methanol extract with half maximal inhibitory concentration value (IC50) of 381.189µg/mL. In contrast, the IC50 value of vitamin C was 416.667µg/mL. These results indicate that the methanolic extract of G. tournefortii exhibits superior antioxidant activity compared to vitamin C. These findings show the significance of the antioxidant effectivity of G. tournefortii, which can be potentially used as an antioxidant supplement. We are excited to announce that this study is the first to successfully isolate rutin and gallic acid from the aerial parts of the Iraqi G.tournefortii. | ||
| کلیدواژه‌ها | ||
| Gundelia tournefortii؛ Reverse Phase HPLC-UV-Vis؛ IC50؛ preparative liquid chromatography (PLC)؛ Soxhlet extraction | ||
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آمار تعداد مشاهده مقاله: 15 تعداد دریافت فایل اصل مقاله: 10 |
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