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Abdulateef Abdullah, Zina, Fouad Ali, Layla. (1404). Severity of COVID-19 infection correlation with IL-17 polymorphism. سامانه مدیریت نشریات علمی, 80(2), 425-434. doi: 10.32592/ARI.2025.80.2.425
Zina Abdulateef Abdullah; Layla Fouad Ali. "Severity of COVID-19 infection correlation with IL-17 polymorphism". سامانه مدیریت نشریات علمی, 80, 2, 1404, 425-434. doi: 10.32592/ARI.2025.80.2.425
Abdulateef Abdullah, Zina, Fouad Ali, Layla. (1404). 'Severity of COVID-19 infection correlation with IL-17 polymorphism', سامانه مدیریت نشریات علمی, 80(2), pp. 425-434. doi: 10.32592/ARI.2025.80.2.425
Abdulateef Abdullah, Zina, Fouad Ali, Layla. Severity of COVID-19 infection correlation with IL-17 polymorphism. سامانه مدیریت نشریات علمی, 1404; 80(2): 425-434. doi: 10.32592/ARI.2025.80.2.425

Severity of COVID-19 infection correlation with IL-17 polymorphism

Archives of Razi Institute
مقاله 7، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 425-434    اصل مقاله (543.7 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.2.425
نویسندگان
Zina Abdulateef Abdullah* ؛ Layla Fouad Ali
University of Baghdad, College of Science, Department of Biology, Baghdad, Iraq.
چکیده
Single nucleotide polymorphisms (SNPs) in many studied genes have been related to the severity of COVID-19. This study was carried out to investigate whether the polymorphisms of two SNPs (rs763780 and rs2275913) of the gene polymorphisms for IL-17 are connected to the COVID-19 severity. The effect of these polymorphisms on the levels of IL-17 and the relationship between the level of IL-17 and the severity of COVID-19 were also investigated. RT-PCR was performed to detect SARS-COV-2. Blood samples have been taken for analyses of IL-17 levels by ELISA test and Genomic DNA was extracted for genotyping. Genotyping was performed using Real Time –Polymerase Chain Reaction. The results indicated that the IL-17 level significantly increases in patients compared with control (healthy people) and there is a relationship between the severity of COVID-19 and IL-17 levels (p<0.01) between severity group. Mean ± SE of IL-17 was 67.99 ±2.05 ng/L for the control group, 147.60 ±3.34 for mild or moderate, (218.15 ±6.27) for the severe group and (283.97 ±5.59) for the critical group. And there is no-significant Relationship between SNP80 and IL-17 level (ng/L) with different types of severity and there is no-significant Relationship between SNP13 and IL-17 level (ng/L) with different types of severity (p ≤ 0.05) both of them. The severity of COVID-19 and the prevalence of the AA genotype were shown to be significantly correlated. Nevertheless, rs2275913 A-allele carriers in the patients were shown to be at risk (P = 0.021) comparison with control group, show increase risk in the severe group (p-value= 0.005, p>0.05) and critical group (p-value = 0.023, p>0.05) but no compact between the mild group, There is no relationship (p< 0.05) between the prevalence of the GA genotype and the severity of COVID-19.
کلیدواژه‌ها
RT-PCR؛ SARS-CoV-2؛ intrlukin-17, HRM RT-PCR, SNP
مراجع
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