اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,035
تعداد مقالات33,961
تعداد مشاهده مقاله45,470,730
تعداد دریافت فایل اصل مقاله71,519,571
Mustafa, Ibrahim, Jimoh, Lukman, Tanko, Yusuf. (1404). Pinocembrin Isolated from Nigerian Propolis Prevents Elevation of Cytokines Implicated in the Aetiology of Diabetic Retinopathy in Rat Models of Diabetes Mellitus. سامانه مدیریت نشریات علمی, 80(3), 783-790. doi: 10.32592/ARI.2025.80.3.783
Ibrahim Oladayo Mustafa; Lukman Jimoh; Yusuf Tanko. "Pinocembrin Isolated from Nigerian Propolis Prevents Elevation of Cytokines Implicated in the Aetiology of Diabetic Retinopathy in Rat Models of Diabetes Mellitus". سامانه مدیریت نشریات علمی, 80, 3, 1404, 783-790. doi: 10.32592/ARI.2025.80.3.783
Mustafa, Ibrahim, Jimoh, Lukman, Tanko, Yusuf. (1404). 'Pinocembrin Isolated from Nigerian Propolis Prevents Elevation of Cytokines Implicated in the Aetiology of Diabetic Retinopathy in Rat Models of Diabetes Mellitus', سامانه مدیریت نشریات علمی, 80(3), pp. 783-790. doi: 10.32592/ARI.2025.80.3.783
Mustafa, Ibrahim, Jimoh, Lukman, Tanko, Yusuf. Pinocembrin Isolated from Nigerian Propolis Prevents Elevation of Cytokines Implicated in the Aetiology of Diabetic Retinopathy in Rat Models of Diabetes Mellitus. سامانه مدیریت نشریات علمی, 1404; 80(3): 783-790. doi: 10.32592/ARI.2025.80.3.783

Pinocembrin Isolated from Nigerian Propolis Prevents Elevation of Cytokines Implicated in the Aetiology of Diabetic Retinopathy in Rat Models of Diabetes Mellitus

Archives of Razi Institute
مقاله 28، دوره 80، شماره 3، مرداد و شهریور 2025، صفحه 783-790    اصل مقاله (562.12 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.3.783
نویسندگان
Ibrahim Oladayo Mustafa* 1؛ Lukman Jimoh2؛ Yusuf Tanko2
1Department of Physiology, Faculty of Basic Medical Science, Federal University Oye-Ekiti, Ekiti.
2Department of Physiology, Faculty of Basic Medical Science, Ahmadu Bello University Zaria
چکیده
AbstractIntroduction: Propolis, a bee-produced resin, contains the flavonoid compound pinocembrin, which shows promise for antioxidant and anti-inflammatory applications, though its therapeutic potential remains underexplored. Diabetic retinopathy, a common complication of diabetes, involves retinal inflammation and vascular damage. Prior research indicates Nigerian propolis may have anti-hyperglycemic effects and the ability to lower glycosylated hemoglobin levels.Methods: The study evaluated the protective effects of pinocembrin, extracted from Nigerian propolis, against diabetic retinopathy in a streptozotocin-induced rat model. Diabetes was induced in male Sprague-Dawley rats through a single intraperitoneal injection of streptozotocin, resulting in sustained hyperglycemia. The diabetic rats were then administered oral pinocembrin at a dose of 50 mg/kg daily for 8 weeks.Results: Pinocembrin administration effectively mitigated the elevation of inflammatory mediators, including Interleukin-1 (IL-1), Interleukin-8 (IL-8), and Tumor Necrosis Factor-alpha (TNF-α), within the retinal tissues of the treated diabetic rats. Furthermore, pinocembrin enhanced the levels of the antioxidant enzymes Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSH-Px), and also improved glycemic control and glycosylated hemoglobin levels.Conclusion: The results indicate that pinocembrin possesses significant therapeutic value for preventing or mitigating diabetic retinopathy. Its capacity to regulate inflammatory processes and bolster antioxidant defenses underscores its potential as a treatment strategy for managing this vision-threatening complication associated with diabetes mellitus.Keywords: Pinocembrin, Nigerian propolis, diabetic retinopathy, inflammation, antioxidants, streptozotocin-induced diabetesIntroduction.

Propolis, a resinous material gathered by honeybees from diverse plant sources, exemplifies nature's remarkable medicinal capacity. Produced by honeybees, propolis is created as bees collect resins, waxes, and other botanical exudates from various plant sources, blending them with enzymes and beeswax. This complex mixture serves a vital role in the hive, acting as a sealant to protect against drafts, maintain hive hygiene, and defend against invading pathogens.
کلیدواژه‌ها
Constituent compound؛ propolis؛ antioxidants؛ streptozotocin-induced diabetes
مراجع
  1. Marcucci MC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83-99.
  2. Krell R. Value-added products from beekeeping: Food & Agriculture Org.; 1996.
  3. Toreti VC, Sato HH, Pastore GM, Park YK. Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence‐Based Complementary and Alternative Medicine. 2013;2013(1):697390.
  4. Anjum SI, Ullah A, Khan KA, Attaullah M, Khan H, Ali H, et al. Composition and functional properties of propolis (bee glue): A review. Saudi journal of biological sciences. 2019;26(7):1695-703.
  5. Simone-Finstrom M, Borba RS, Wilson M, Spivak M. Propolis counteracts some threats to honey bee health. Insects. 2017;8(2):46.
  6. Król W, Bankova V, Sforcin JM, Szliszka E, Czuba Z, Kuropatnicki AK. Propolis: properties, application, and its potential. Evidence-based complementary and alternative medicine: eCAM. 2013;2013:807578.
  7. Hossain R, Quispe C, Khan RA, Saikat ASM, Ray P, Ongalbek D, et al. Propolis: An update on its chemistry and pharmacological applications. Chinese medicine. 2022;17(1):100.
  8. Huang S, Zhang C-P, Wang K, Li GQ, Hu F-L. Recent advances in the chemical composition of propolis. Molecules. 2014;19(12):19610-32.
  9. Banskota AH, Tezuka Y, Kadota S. Recent progress in pharmacological research of propolis. Phytotherapy research. 2001;15(7):561-71.
  10. Shen X, Liu Y, Luo X, Yang Z. Advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug. Molecules. 2019;24(12):2323.
  11. Šturm L, Ulrih NP. Advances in the propolis chemical composition between 2013 and 2018: A review. Efood. 2020;1(1):24-37.
  12. Cheung N, Mitchell P. Wong TYLancet. Diabetic retinopathy. 2010;376(9735):124-36.
  13. Semeraro F, Cancarini A, dell’Omo R, Rezzola S, Romano MR, Costagliola C. Diabetic retinopathy: vascular and inflammatory disease. Journal of diabetes research. 2015;2015(1):582060.
  14. Rübsam A, Parikh S, Fort PE. Role of inflammation in diabetic retinopathy. International journal of molecular sciences. 2018;19(4):942.
  15. Kumazawa S, Bonvehí JS, Torres C, Mok‐Ryeon A, Bermejo FJO. Chemical and functional characterisation of propolis collected from East Andalusia (Southern Spain). Phytochemical analysis. 2013;24(6):608-15.
  16. Oladayo MI. Nigerian propolis improves blood glucose, glycated hemoglobin A1c, very low-density lipoprotein, and high-density lipoprotein levels in rat models of diabetes. Journal of intercultural ethnopharmacology. 2016;5(3):233.
  17. Fanaro GB, Marques MR, Calaza KdC, Brito R, Pessoni AM, Mendonça HR, et al. New insights on dietary polyphenols for the Management of Oxidative Stress and Neuroinflammation in diabetic retinopathy. Antioxidants. 2023;12(6):1237.
  18. Yue T, Shi Y, Luo S, Weng J, Wu Y, Zheng X. The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Frontiers in immunology. 2022;13:1055087.
  19. Elbatreek MH, Mahdi I, Ouchari W, Mahmoud MF, Sobeh M. Current advances on the therapeutic potential of pinocembrin: an updated review. Biomedicine & Pharmacotherapy. 2023;157:114032.
  20. Rasul A, Millimouno FM, Ali Eltayb W, Ali M, Li J, Li X. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. BioMed research international. 2013;2013(1):379850.
  21. Kropp M, Golubnitschaja O, Mazurakova A, Koklesova L, Sargheini N, Vo T-TKS, et al. Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation. Epma Journal. 2023;14(1):21-42.
  22. Park JW, Sung MS, Ha JY, Guo Y, Piao H, Heo H, et al. Neuroprotective effect of Brazilian green propolis on retinal ganglion cells in ischemic mouse retina. Current eye research. 2020;45(8):955-64.
  23. Karagecili H, Yılmaz MA, Ertürk A, Kiziltas H, Güven L, Alwasel SH, et al. Comprehensive metabolite profiling of Berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects. Molecules. 2023;28(4):1739.
  24. Nna VU, Abu Bakar AB, Zakaria Z, Othman ZA, Jalil NAC, Mohamed M. Malaysian propolis and metformin synergistically mitigate kidney oxidative stress and inflammation in streptozotocin-induced diabetic rats. Molecules. 2021;26(11):3441.
آمار
تعداد مشاهده مقاله: 67
تعداد دریافت فایل اصل مقاله: 111


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب