اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,074
تعداد مقالات34,304
تعداد مشاهده مقاله47,172,347
تعداد دریافت فایل اصل مقاله78,082,495
Fadaei, Shahla, Hassanpour, Shahin, Eidi, Akram, Zendehdel, Morteza. (1404). Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice. سامانه مدیریت نشریات علمی, 80(4), 1059-1067. doi: 10.32592/ARI.2025.80.4.1059
Shahla Fadaei; Shahin Hassanpour; Akram Eidi; Morteza Zendehdel. "Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice". سامانه مدیریت نشریات علمی, 80, 4, 1404, 1059-1067. doi: 10.32592/ARI.2025.80.4.1059
Fadaei, Shahla, Hassanpour, Shahin, Eidi, Akram, Zendehdel, Morteza. (1404). 'Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice', سامانه مدیریت نشریات علمی, 80(4), pp. 1059-1067. doi: 10.32592/ARI.2025.80.4.1059
Fadaei, Shahla, Hassanpour, Shahin, Eidi, Akram, Zendehdel, Morteza. Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice. سامانه مدیریت نشریات علمی, 1404; 80(4): 1059-1067. doi: 10.32592/ARI.2025.80.4.1059

Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice

Archives of Razi Institute
مقاله 26، دوره 80، شماره 4، مهر و آبان 2025، صفحه 1059-1067    اصل مقاله (514.18 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.4.1059
نویسندگان
Shahla Fadaei1؛ Shahin Hassanpour* 2؛ Akram Eidi1؛ Morteza Zendehdel3
1Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.
2Department of Veterinary Basic Sciences, SR.C., Islamic Azad University, Tehran, Iran.
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran.
چکیده
This paper aimed to determine effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice. Forty pregnant female NMRI mice were allocated into four groups. In the control group, pregnant mice were given water as a placebo, whereas pregnant female mice in groups 2-4 were orally administered sericin (112.5, 225, and 450 mg/kg) at different days of gestation (5, 8, 11, 14, and 17). Following postpartum, open field test (OFT), forced swimming test ( FST ), tail suspension test ( TST ) and open field tests were used to evaluate depressive-like antidepressant activity of sericin. At the end of the study, serum growth hormone (GH), Insulin-like growth factor-1 (IGF-1), Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) levels were determined. According to the results, sericin administration during pregnancy decreased immobility time in FST and TST and increased number of cross in OFT compared to control group (P<0.05). Exposure to sericin significantly decreased serum MDA while increased SOD, GPx and TAS levels compared with the control group (P<0.05). Also, sericin exposure during gestation significantly increased serum GH and IGF-1 levels compared to the control group (P<0.05). These results suggested pre-partum administration of sericin has antidepressant effect in postpartum mice.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
کلیدواژه‌ها
Sericin؛ Antioxidant؛ Parturition؛ Mice
سایر فایل های مرتبط با مقاله
مراجع
  1. Anisman H, Merali Z. Rodent models of depression: learned helplessness induced in mice. Current protocols in neuroscience. 2001;14(1):8.10 C. 1-8. C. 5
  2. Gregus A, Wintink AJ, Davis AC, Kalynchuk LE. Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. Behavioural brain research. 2005;156(1):105-14
  3. Holsboer F, Von Bardeleben U, Wiedemann K, Müller O, Stalla G. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression: Implications for pathophysiology of DST nonsuppression. Biological psychiatry. 1987
  4. Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2012;39(1):112-9
  5. Calcia MA, Bonsall DR, Bloomfield PS, Selvaraj S, Barichello T, Howes OD. Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness. Psychopharmacology. 2016;233:1637-50
  6. Mohammadi AB, Torbati M, Farajdokht F, Sadigh-Eteghad S, Fazljou SMB, Vatandoust SM, et al. Sericin alleviates restraint stress induced depressive-and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. Brain research. 2019;1715:47-56
  7. Mahmoudi J, Hosseini L, Sadigh-Eteghad S, Farajdokht F, Vatandoust SM, Zn785iaee M. Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus. Neurochemical Research. 2021;46:2307 - 16
  8. Farajdokht F, Vatandoust SM, Hosseini L, Fekri K, Aghsan SR, Majdi A, et al. Sericin protects against acute sleep deprivation-induced memory impairment via enhancement of hippocampal synaptic protein levels and inhibition of oxidative stress and neuroinflammation in mice. Brain research bulletin. 2021;174:203-11
  9. Li Y-G, Ji D-F, Chen S, Hu G-Y. Protective effects of sericin protein on alcohol-mediated liver damage in mice. Alcohol & Alcoholism. 2008;43(3):246-53
  10. Adachi T, Iwashita M, Watanabe M, Takeda Y, Sakamoto S. [The effect of maternal IGF-I on fetal and placental growth in mice]. Nihon Naibunpi Gakkai zasshi. 1991;67 5:636-44
  11. Song C, Yang Z, Tang Q-f, Chen Z. Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes. International journal of clinical and experimental medicine. 2015;8 7:10411-9
  12. Khodadadeh A, Hassanpour S, Akbari G. Prenatal exposure to hesperidin improves reflexive motor behaviors in mice offspring. International Journal of Developmental Neuroscience. 2020
  13. Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neuroscience & Biobehavioral Reviews. 2005;29(4-5):571-625
  14. Sausan S, Fitriana M, Abdillah LK, Lisi FH, Indriani ZI, Hidayat LH, et al. Uji Aktivitas Antidepresan Ramuan Buah Adas (Foeniculum vulgare Mill.) Pada Mencit Jantan (Mus musculus) Dengan Metode Tail Suspension Test (TST). Baphomet University: Situs Slot Online Gacor Terbaik Hari ini Server Thailand Gampang Maxwin 2024. 2023;12(2)
  15. Sen MK, Mahns DA, Coorssen JR, Shortland PJ. Behavioural phenotypes in the cuprizone model of central nervous system demyelination. Neuroscience & Biobehavioral Reviews. 2019;107:23-46
  16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry. 1976;72(1-2):248-54
  17. Saharoy R, Potdukhe A, Wanjari M, Taksande AB. Postpartum depression and maternal care: exploring the complex effects on mothers and infants. Cureus. 2023;15(7)
  18. Walia V, Gilhotra N. Nitriergic influence in the compromised antidepressant effect of fluoxetine in stressed mice. Journal of Applied Pharmaceutical Science. 2016;6(10):092-7
  19. Becker M, Pinhasov A, Ornoy A. Animal models of depression: what can they teach us about the human disease? Diagnostics. 2021;11(1):123
  20. Vatandoust SM, Meftahi GH. The effect of sericin on the cognitive impairment, depression, and anxiety caused by learned helplessness in male mice. Journal of Molecular Neuroscience. 2022;72(5):963-74
  21. Aramwit P, Towiwat P, Srichana T. Anti-inflammatory Potential of Silk Sericin. Natural Product Communications. 2013;8
  22. Bagheri Y, Sadigh-Eteghad S, Fathi E, Mahmoudi J, Abdollahpour A, Namini NJ, et al. Hepatoprotective effects of sericin on aging-induced liver damage in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2021;394:2441-50
  23. Farajdokht F, Sadigh-Eteghad S, Vatandoust S, Hosseini L, Morsali S, Feizi H, et al. Sericin Improves Memory Impairment Via Activation of the PKA-CREB-BDNF Signaling Pathway and Suppression of Oxidative Stress in Ovariectomized Mice. Neurochemical Research. 2024:1-12
  24. Camkurt MA, Fındıklı E, Bakacak M, Tolun Fİ, Karaaslan MF. Evaluation of malondialdehyde, superoxide dismutase and catalase activity in fetal cord blood of depressed mothers. Clinical Psychopharmacology and Neuroscience. 2017;15(1):35
  25. Song Y, Zhang C, Zhang J, Sun N, Huang K, Li H, et al. An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction. Acta biomaterialia. 2016;41:210-23
آمار
تعداد مشاهده مقاله: 157
تعداد دریافت فایل اصل مقاله: 101


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب