اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,067
تعداد مقالات34,232
تعداد مشاهده مقاله47,009,524
تعداد دریافت فایل اصل مقاله77,945,232
Osanloo, Mahmood, Alipanah, Hiwa, Hashempour, Mohammad Arman, Motazedian, Benyamin, Zarenezhad, Elham, Zahedifard, Zahra, Ghasemian, Abdolmajid. (1404). The antimicrobial and antibiofilm potential of Citrus aurantium and Artemisia annua essential oils nanoemulsions against standard and multidrug-resistant nosocomial pathogens. سامانه مدیریت نشریات علمی, 80(4), 927-936. doi: 10.32592/ARI.2025.80.4.927
Mahmood Osanloo; Hiwa Alipanah; Mohammad Arman Hashempour; Benyamin Motazedian; Elham Zarenezhad; Zahra Zahedifard; Abdolmajid Ghasemian. "The antimicrobial and antibiofilm potential of Citrus aurantium and Artemisia annua essential oils nanoemulsions against standard and multidrug-resistant nosocomial pathogens". سامانه مدیریت نشریات علمی, 80, 4, 1404, 927-936. doi: 10.32592/ARI.2025.80.4.927
Osanloo, Mahmood, Alipanah, Hiwa, Hashempour, Mohammad Arman, Motazedian, Benyamin, Zarenezhad, Elham, Zahedifard, Zahra, Ghasemian, Abdolmajid. (1404). 'The antimicrobial and antibiofilm potential of Citrus aurantium and Artemisia annua essential oils nanoemulsions against standard and multidrug-resistant nosocomial pathogens', سامانه مدیریت نشریات علمی, 80(4), pp. 927-936. doi: 10.32592/ARI.2025.80.4.927
Osanloo, Mahmood, Alipanah, Hiwa, Hashempour, Mohammad Arman, Motazedian, Benyamin, Zarenezhad, Elham, Zahedifard, Zahra, Ghasemian, Abdolmajid. The antimicrobial and antibiofilm potential of Citrus aurantium and Artemisia annua essential oils nanoemulsions against standard and multidrug-resistant nosocomial pathogens. سامانه مدیریت نشریات علمی, 1404; 80(4): 927-936. doi: 10.32592/ARI.2025.80.4.927

The antimicrobial and antibiofilm potential of Citrus aurantium and Artemisia annua essential oils nanoemulsions against standard and multidrug-resistant nosocomial pathogens

Archives of Razi Institute
مقاله 13، دوره 80، شماره 4، مهر و آبان 2025، صفحه 927-936    اصل مقاله (612.05 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.4.927
نویسندگان
Mahmood Osanloo1؛ Hiwa Alipanah2؛ Mohammad Arman Hashempour3؛ Benyamin Motazedian3؛ Elham Zarenezhad4؛ Zahra Zahedifard5؛ Abdolmajid Ghasemian* 4
1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
2Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
3Department of Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
4Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
5Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran.
چکیده
Antimicrobial resistance has posed considerable health and economic burdens globally (approximately five million deaths annually), particularly among developing countries. The estimated annual treatment costs in the United States include US$4.6 billion. Vast antibiotic resistance among Gram-negative and Gram-positive bacterial species has spread from healthcare to the environment, community, and animals. These conditions have limited and sometimes failed the infection eradication choices and facilitated the distribution of drug-resistant organisms. The spread of drug-resistant bacterial infections is a huge human health concern, hence seeking novel antibacterial agents is crucial. This study used the nanoemulsions of Citrus aurantium and Artemisia annua essential oils (EOs) as natural antibacterial agents. GC–MS analysis showed that limonene (31.4%) and artemisia ketone (26.2%) were major components, respectively. After that, their nanoemulsion dosage forms with a mean droplet size of 181 ± 7 and 160 ± 5 and with zeta potential values 3.1 ± 0.8 and -4.9 ± 0.5 mV were prepared. Meanwhile, successful loading of the EOs in nanoemulsion was confirmed by ATR-FTIR analysis. A. annua nanoemulsion with 40% antioxidant effect was significantly more potent than C. aurantium nanoemulsion. Meanwhile, nanoemulsions' antibacterial and antibiofilm activity against clinical and standard strains, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia, were investigated. The best efficiency was related to the effect of C. aurantium nanoemulsion against S. aureus; MIC and MBC were 500 and > 2000 µg/mL. Besides, no biofilm was formed after treatment by both nanoemulsions. Therefore, C. aurantium and A. annua EO nanoemulsions may act as natural antioxidant and antibacterial agents in complementary medicine.
کلیدواژه‌ها
Antibacterial Agents؛ Essential Oil؛ Reactive Oxygen Species؛ Phytochemicals
سایر فایل های مرتبط با مقاله
مراجع
  1. Mestrovic T, Aguilar GR, Swetschinski LR, Ikuta KS, Gray AP, Weaver ND, et al. The burden of bacterial antimicrobial resistance in the WHO European region in 2019: A cross-country systematic analysis. The Lancet Public Health. 2022;7(11):e897-e913
  2. Laxminarayan R. The overlooked pandemic of antimicrobial resistance. The Lancet. 2022;399(10325):606-7
  3. Noorpisheh Ghadimi S, Sharifi N, Osanloo M. The leishmanicidal activity of essential oils: A systematic review. Journal of Herbmed Pharmacology. 2020;9(4):300-8.https://doi.org/10.34172/jhp.2020.38
  4. Qasemi H, Fereidouni Z, Karimi J, Abdollahi A, Zarenezhad E, Rasti F, et al. Promising antibacterial effect of impregnated nanofiber mats with a green nanogel against clinical and standard strains of Pseudomonas aeruginosa and Staphylococcus aureus. Journal of Drug Delivery Science and Technology. 2021.
  5. Kanwar R, Rathee J, Salunke DB, Mehta SK. Green nanotechnology-driven drug delivery assemblies. ACS omega. 2019;4(5):8804-15
  6. Swain SS, Paidesetty SK, Padhy RN, Hussain T. Nano-technology platforms to increase the antibacterial drug suitability of essential oils: A drug prospective assessment. OpenNano. 2022:100115
  7. Rahchamani R, Zarooni S, Borhani MS. The Chemical Composition and Antibacterial Effect of Essential Oils of Rosemary and Basil in Milk. Iranian Journal of Veterinary Medicine. 2024
  8. Farzaneh M, Fadaei V, Gandomi H. Antioxidant, Syneresis, and Sensory Characteristics of Probiotic Yogurt Incorporated With Agave tequilana Aqueous Extract. Iranian Journal of Veterinary Medicine. 2023;17(3):243-52
  9. Ali Anvar SA, Nowruzi B, Afshari G. A Review of the Application of Nanoparticles Biosynthesized by Microalgae and Cyanobacteria in Medical and Veterinary Sciences. Iranian Journal of Veterinary Medicine. 2023;17(1)
  10. Khaji L, Noori N, Jebelli Javan A, Khanjari A, Ghandomi Nasrabadi H. antimicrobial effect of Cuminum Cyminum essential oil on Iranian white soft cheese in air and modified atmosphere packaging during refrigerated storage. Iranian Journal of Veterinary Medicine. 2023
  11. Maksoud S, Abdel-Massih RM, Rajha HN, Louka N, Chemat F, Barba FJ, et al. Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review. Molecules. 2021;26(19).https://doi.org/10.3390/molecules26195832.
  12. Gao L, Zhang H, Yuan CH, Zeng LH, Xiang Z, Song JF, et al. Citrus aurantium 'Changshan-huyou'-An ethnopharmacological and phytochemical review. Front Pharmacol. 2022;13:983470.
  13. Liu S, Lou Y, Li Y, Zhang J, Li P, Yang B, et al. Review of phytochemical and nutritional characteristics and food applications of Citrus L. fruits. Front Nutr. 2022;9:968604.https://doi.org/10.3389/fnut.2022.968604.
  14. Okla MK, Alamri SA, Salem MZ, Ali HM, Behiry SI, Nasser RA, et al. Yield, phytochemical constituents, and antibacterial activity of essential oils from the leaves/twigs, branches, branch wood, and branch bark of Sour Orange (Citrus aurantium L.). Processes. 2019;7(6):363
  15. Kačániová M, Terentjeva M, Galovičová L, Ivanišová E, Štefániková J, Valková V, et al. Biological activity and antibiofilm molecular profile of Citrus aurantium essential oil and its application in a food model. Molecules. 2020;25(17):3956
  16. Anibogwu R, Jesus K, Pradhan S, Pashikanti S, Mateen S, Sharma K. Extraction, Isolation and Characterization of Bioactive Compounds from Artemisia and Their Biological Significance: A Review. Molecules. 2021;26(22).https://doi.org/10.3390/molecules26226995.
  17. Bilia AR, Santomauro F, Sacco C, Bergonzi MC, Donato R. Essential Oil of Artemisia annua L.: An Extraordinary Component with Numerous Antimicrobial Properties. Evid Based Complement Alternat Med. 2014;2014:159819.https://doi.org/10.1155/2014/159819.
  18. Mirzaei-Najafgholi H, Tarighi S, Golmohammadi M, Taheri P. The Effect of Citrus Essential Oils and Their Constituents on Growth of Xanthomonas citri subsp. citri. Molecules. 2017;22(4):591
  19. Osanloo M, Ghaznavi G, Abdollahi A. Sureveying the chemical composition and antibacterial activity of essential oils from selected medicinal plants against human pathogens. Iranian Journal of Microbiology. 2020;12(6):505-12
  20. Durán Aguirre CE, Pratissoli D, Damascena AP, Romário de Carvalho J, de Araujo Junior LM. Lethal and sublethal effects of Citrus aurantium and Citrus sinensis essential oils and their major component limonene on Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae). Journal of Essential Oil Bearing Plants. 2024;27(3):838-48.https://doi.org/10.1080/0972060X.2023.2286259.
  21. Madhuri S, Hegde AU, Srilakshmi N, Prashith Kekuda T. Antimicrobial activity of Citrus sinensis and Citrus aurantium peel extracts. Journal of Pharmaceutical and Scientific Innovation (JPSI). 2014;3(4):366-8
  22. Marinas IC, Oprea E, Chifiriuc MC, Badea IA, Buleandra M, Lazar V. Chemical composition and antipathogenic activity of Artemisia annua essential oil from Romania. Chemistry & Biodiversity. 2015;12(10):1554-64
  23. Al-Mothafar NA, Al-Shahwany AW. Phenolic compounds from Thymus vulgaris, Artemisia annua extracts and pure Thymol were tested against twenty Pseudomonas spp. strains for antibacterial and anti-biofilm activities. IOP Journal of Physics Under review.
  24. Das S, Vörös-Horváth B, Bencsik T, Micalizzi G, Mondello L, Horváth G, et al. Antimicrobial activity of different Artemisia essential oil formulations. Molecules. 2020;25(10):2390
  25. Mariadoss AVA, Saravanakumar K, Sathiyaseelan A, Naveen KV, Wang M-H. Enhancement of anti-bacterial potential of green synthesized selenium nanoparticles by starch encapsulation. Microbial Pathogenesis. 2022;167:105544
آمار
تعداد مشاهده مقاله: 238
تعداد دریافت فایل اصل مقاله: 128


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب