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Lactobacillus & Bifidobacterium of Patients with Strongyloidiasis Compared to the Control Group | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 آبان 1403 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2024.365730.3129 | ||
| نویسندگان | ||
| Arezou Kazeminejad1؛ Eshrat Beigom Kia1؛ sareh bagheri-josheghani2؛ Enayat Darabi3؛ Noshin Fahimfar1؛ Zohreh Fakhrieh* 4 | ||
| 1Tehran University of Medical Sciences, Tehran, Iran. | ||
| 2kashan university of medical science | ||
| 3Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Tehran University of Medical Sciences | ||
| چکیده | ||
| In individuals with compromised immune systems, strongyloidiasis disease can lead to disseminated infections that can be fatal if diagnosis and treatment are delayed. The human gut is composed of numerous bacteria that play essential roles in the development of acquired immunity, and protection against pathogenic factors. This case-control study was conducted on individuals who were referred to the Diagnostic Laboratory of Strongyloidiasis in the School of Public Health, Tehran University of Medical Sciences. After DNA extraction from fecal samples, the 16SrRNA gene was examined using Real-time PCR. The levels of Lactobacillus acidophilus and Bifidobacterium bifidium were calculated in both groups (one group consisted of individuals suspected of strongyloidiasis compared with the other group with no underlying disease). Finally, the collected data were analyzed. Out of 28 people participants in this study, 16 (57%) were men and 12 (43%) were women, with age ranging from 43 to 76 years. A statistically significant relationship was observed between underlying diseases, vegetable washing practices, and clinical symptoms of strongyloidiasis. DNA extraction from the fecal samples was performed using the DNA Extraction kit. The average level of L. acidophilus and B. bifidium were (4.07250±3.132533) 10 12 × and, (6.12857±3.519169) 10 12 × in the case group respectively, which were lower compared to the control group but no significant association was found between the level of bacterial in the case and control groups and the incidence of strongyloidiasis (p > 0.05), there had (7.04733± 6.542372) 10 12 ×and (8.36643± 4.754185) 1012× respectively. The odds ratio was L. acidophilus and B. bifidium 1.13 and 1.14, respectively. It was observed that for each increase in the number of 10 12 in the microliter for L.acidophilus and B. bifidium in the individual’s intestines in areas endemic for strongyloidiasis, the chances of contracting this disease decreased by 13% and 14%, respectively. Future studies with a higher volume considering age, gender and other physiological factors related to strongyloidiasis are suggested. | ||
| کلیدواژه‌ها | ||
| Bifidobacterium bifidium؛ Lactobacillus acidophilus؛ Strongyloidiasis | ||
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آمار تعداد مشاهده مقاله: 28 |
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