اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,051
تعداد مقالات34,085
تعداد مشاهده مقاله46,578,978
تعداد دریافت فایل اصل مقاله77,620,184
ADELEKE, Opeyemi, Iyiola, Olalekan, Johnson, Olawumi, Adunfe, Oluwatobi, Benson, Iyanuoluwa, Oyewopo, Adeoye. (1404). Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats. سامانه مدیریت نشریات علمی, 80(2), 408-415. doi: 10.32592/ARI.2025.80.2.408
Opeyemi Samson ADELEKE; Olalekan Blessing Iyiola; Olawumi Feyisike Johnson; Oluwatobi Oluseun Adunfe; Iyanuoluwa Olushola Benson; Adeoye Oyetunji Oyewopo. "Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats". سامانه مدیریت نشریات علمی, 80, 2, 1404, 408-415. doi: 10.32592/ARI.2025.80.2.408
ADELEKE, Opeyemi, Iyiola, Olalekan, Johnson, Olawumi, Adunfe, Oluwatobi, Benson, Iyanuoluwa, Oyewopo, Adeoye. (1404). 'Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats', سامانه مدیریت نشریات علمی, 80(2), pp. 408-415. doi: 10.32592/ARI.2025.80.2.408
ADELEKE, Opeyemi, Iyiola, Olalekan, Johnson, Olawumi, Adunfe, Oluwatobi, Benson, Iyanuoluwa, Oyewopo, Adeoye. Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats. سامانه مدیریت نشریات علمی, 1404; 80(2): 408-415. doi: 10.32592/ARI.2025.80.2.408

Riboceine Regimen Circumvents Reserpine-Induced Hepatotoxicity via the Modulation of Key Liver Function Markers in Adult Male Wistar Rats

Archives of Razi Institute
مقاله 15، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 408-415    اصل مقاله (549.81 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.2.408
نویسندگان
Opeyemi Samson ADELEKE1؛ Olalekan Blessing Iyiola* 1؛ Olawumi Feyisike Johnson2؛ Oluwatobi Oluseun Adunfe3؛ Iyanuoluwa Olushola Benson1؛ Adeoye Oyetunji Oyewopo4
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun State, Nigeria.
2Department of Anatomy, University of Medical Sciences, Ondo City, Nigeria
3Anatomy Unit, Department of Medical Laboratory Sciences, College of Basic and Health Sciences, Fountain University, Osogbo, Osun State, Nigeria.
4Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Kwara State, Nigeria.
چکیده
Reserpine, an antipsychotic and antihypertensive medication, has been associated with liver damage and dysfunction. This study examined the potential hepatoprotective effect of a riboceine regimen against reserpine-induced hepatotoxicity in adult male Wistar rats. Twenty-five (25) Adult male Wistar rats were randomly divided into five groups: Control, Reserpine, Reserpine + Citalopram, Reserpine + Riboceine, and Reserpine + Citalopram + Riboceine. Liver function markers, including alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP), were analyzed in serum samples to assess liver health. Additionally, a histopathological examination of liver tissue was performed to visualize any morphological changes.
Rats treated with reserpine alone displayed a significant increase in serum ALT and AST, levels compared to the control group, indicating hepatocellular damage. In contrast, the Riboceine + Reserpine group exhibited a marked reduction in ALT and AST levels compared to the Reserpine group, suggesting a protective effect of riboceine against reserpine-induced hepatotoxicity. No significant difference was observed in the serum level of ALP across the experimental groups. Histopathological examination confirmed the attenuated liver injury in the Riboceine + Reserpine group, with a reduction in necrotic areas and inflammation compared to the Reserpine group.
The results demonstrate that a riboceine regimen effectively circumvents reserpine-induced hepatotoxicity in adult male Wistar rats. The modulation of key liver function markers, along with histopathological evidence, supports the hepatoprotective role of riboceine in mitigating liver damage induced by reserpine. This study provides promising insights into the potential therapeutic application of riboceine as a hepatoprotective agent, which could be beneficial for patients undergoing treatment with reserpine or similar medications. Further research is warranted to explore the underlying mechanisms of riboceine's protective effects and its potential clinical applications
کلیدواژه‌ها
Reserpine؛ Riboceine؛ Hepatotoxicity؛ Oxidative stress؛ Citalopram
مراجع
  1. Schimelpfening N. 7 facts you should know about depression [Internet]. Verywell Mind; 2023 Jun 16. Available from: https://www.verywellmind.com/depression-facts-you-should-know-1067617
  2. Ren F, Guo R. Synaptic microenvironment in depressive disorder: insights from synaptic plasticity. Neuropsychiatr Dis Treat. 2021;17:157–65.
  3. Orsolini L, Latini R, Pompili M, Serafini G, Volpe U, Vellante F, et al. Understanding the complex of suicide in depression: from research to clinics. Psychiatry Investig. 2020;17(3):207–21.
  4. Govindarajulu M, Shankar T, Patel S, Fabbrini M, Manohar A, Ramesh S, et al. Reserpine-induced depression and other neurotoxicity: a monoaminergic hypothesis. In: Medicinal Herbs and Fungi: Neurotoxicity vs. Neuroprotection. 2021. p. 293–313.
  5. Mega Obukohwo O, Faith FY, Peggy Ejiro O, Onyebuchi MM, Ajayi AF. Medicinal applications of D-ribose L-cysteine in neuro-endocrinopathy, reproductive dysfunction and cardio-metabolic syndrome: a review of evidence in animal investigations. Eur J Med Chem Rep. 2024;11:100153.
  6. Khushboo, Gupta VK, Sharma B. Hepatoprotective effect of ethanolic extract of garlic against reserpine induced toxicity in Wistar rats. Indian J Clin Biochem. 2022;38(2):251–61.
  7. Sotler R. Prooxidant activities of antioxidants and their impact on health. Acta Clin Croat. 2019;58:0.
  8. Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci. 2021;22(9):4642.
  9. Muriel P, Gordillo KR. Role of oxidative stress in liver health and disease. Oxid Med Cell Longev. 2016;2016:1–2.
  10. De La Rosa LC, Goicoechea L, Torres S, García-Ruiz C, Fernández-Checa JC. Role of oxidative stress in liver disorders. Livers. 2022.
  11. Casas-Grajales S, Muriel P. Antioxidants in liver health. World J Gastrointest Pharmacol Ther. 2015;6(3):59.
  12. Allameh A, Niayesh‐Mehr R, Aliarab A, Barbàra M, Pantopoulos K. Oxidative stress in liver pathophysiology and disease. Antioxidants. 2023.
  13. Abayomi TA, Tokunbo OS, Ajayi M, Abayomi OA, Ofusori DA. Riboceine regimen attenuates ethanol-induced neuronal damage in the cerebellum of adult male Wistar rats. Iran J Toxicol. 2021;15(4):249–56.
  14. Gee D. What is RiboCeine technology and the benefits? [Internet]. MyDiet234; 2018 Oct 11 [cited 2024 Apr 12]. Available from: https://diet234.com/riboceine-technology/
  15. Weir MR. Reserpine: a new consideration of an old drug for refractory hypertension. Am J Hypertens. 2020;33(8):708–10.
  16. Alamri ZZ. The role of liver in metabolism: an updated review with physiological emphasis. Int J Basic Clin Pharmacol. 2018;7(11):2271.
  17. Todorovic T, Vujanovic D. The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues. Magnes Res. 2002;15(3–4):173–7.
  18. Shoar NS, Fariba KA, Padhy RK. Citalopram [Internet]. StatPearls - NCBI Bookshelf; 2023 Nov 7 [cited 2024 Apr 25]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/
  19. Ukwenya VO, Alese MO, Ogunlade B, Folorunso IM, Omotuyi OI. Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes. J Diabetes Metab Disord. 2022.
  20. Liu SB, Zhao R, Liu X, Guo H, Tian Z, Zhang N, et al. Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. Neuromolecular Med. 2014.
  21. Amole O, Akinyede A, Adewale M. Effects of riboceine (Cellgevity) on ulcer models in rats. 2020.
  22. Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A, Berardo C. Changes in glutathione content in liver diseases: an update. Antioxidants. 2021;10(3):364.
  23. Bansal L, Dhiman A. Chronicity of hepatotoxicity: a review. EAS J Med Surg. 2022;4:6–14.
  24. Thomas AB. Modulatory role of riboceine and vitamin C supplementation on altered oxidative stress status of alloxan-induced diabetic Wistar rats. Biosci Biotechnol Res Commun. 2020;13(4):2130–8.
آمار
تعداد مشاهده مقاله: 227
تعداد دریافت فایل اصل مقاله: 349


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب