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Ghasemzadeh-Moghaddam, Hamed, Radmeher, Mohadese, Firouzehirouzeh, Nima, Moghbeli, Majid, Azimian, Amir, Dashti, Vahid, van Belkum, Alex, Salehi, Mitra. (1403). Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran. سامانه مدیریت نشریات علمی, 80(1), 243-248. doi: 10.32592/ARI.2025.80.1.243
Hamed Ghasemzadeh-Moghaddam; Mohadese Radmeher; Nima Firouzehirouzeh; Majid Moghbeli; Amir Azimian; Vahid Dashti; Alex van Belkum; Mitra Salehi. "Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran". سامانه مدیریت نشریات علمی, 80, 1, 1403, 243-248. doi: 10.32592/ARI.2025.80.1.243
Ghasemzadeh-Moghaddam, Hamed, Radmeher, Mohadese, Firouzehirouzeh, Nima, Moghbeli, Majid, Azimian, Amir, Dashti, Vahid, van Belkum, Alex, Salehi, Mitra. (1403). 'Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran', سامانه مدیریت نشریات علمی, 80(1), pp. 243-248. doi: 10.32592/ARI.2025.80.1.243
Ghasemzadeh-Moghaddam, Hamed, Radmeher, Mohadese, Firouzehirouzeh, Nima, Moghbeli, Majid, Azimian, Amir, Dashti, Vahid, van Belkum, Alex, Salehi, Mitra. Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran. سامانه مدیریت نشریات علمی, 1403; 80(1): 243-248. doi: 10.32592/ARI.2025.80.1.243

Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-Resistant Acinetobacter baumannii in Iran

Archives of Razi Institute
مقاله 30، دوره 80، شماره 1، فروردین و اردیبهشت 2025، صفحه 243-248    اصل مقاله (288.95 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.1.243
نویسندگان
Hamed Ghasemzadeh-Moghaddam* 1؛ Mohadese Radmeher2؛ Nima Firouzehirouzeh1؛ Majid Moghbeli3؛ Amir Azimian1؛ Vahid Dashti4؛ Alex van Belkum5؛ Mitra Salehi1
1Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
2Department of Microbiology, Damghan branch, Islamic Azad University, Damghan, Iran.
3Department of Microbiology, Damghan branch, Islamic Azad University, Damghan, Iran
4Imam Hassan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran
5Open Innovation & Partnerships, BaseClear, Sylviusweg 74, 2333 BE Leiden, The Netherlands.
چکیده
Acinetobacter baumannii (A. baumannii) is a prevalent infectious agent regularly reported from hospital intensive care unit (ICU) patients. Annually, Multi-drug-resistant (MDR) isolates present a significant clinical challenge. The present study aimed to determine the prevalence of antiseptic resistance genes and the level of resistance to quaternary ammonium and biguanide compounds in A. baumannii isolates obtained from patients of north Khorasan province.
All obtained A. baumannii isolates were examined for in vitro susceptibility to antiseptic agents and the presence antiseptic resistance encoding genes including qacE, qacEΔ1, and blaOXA-23.

The broth microdilution method detected the Minimum Inhibitory Concentrations (MIC) against antiseptic compounds.
The majority of A. baumannii infections were observed in ICU patients (n=63, 84%). MDR and extensively drug-resistant (XDR) phenotypes were present in 53.2% and 46.7% of cases, respectively. Among 75 isolates, 48 (64%) had at least one resistance gene. This includes 24 (32%) isolates with only the qacE gene and 5 (6.7%) isolates with the qacEΔ1 gene. Coexistence of qacE and qacEΔ1 genes were found in nine (25.3%) isolates. The mean minimum inhibitory concentration (MIC) of chlorhexidine digluconate (CHG) was statistically significantly higher in isolates harboring antiseptic resistance genes than in isolates without such genes (81.4 µg/ml versus 27.9 µg/ml, P=0.001).
The increased MIC against antiseptic agents among A. baumannii isolates is a big medical concern. The presence of antiseptic-resistant genes and increased minimum inhibitory concentration (MIC) levels against antiseptic agents in MDR and XDR A. baumannii emphasizes the critical need for comprehensive monitoring of all A. baumannii isolates in hospital settings to ensure efficient infection control.
کلیدواژه‌ها
Acinetobacter baumannii؛ Multi Drug Resistant؛ Biguanide compound؛ qacE؛ qacEΔ1
مراجع
  1. Antunes LCS, Visca P, Towner KJ. Acinetobacter baumannii: Evolution of a global pathogen. Pathog Dis. 2014;71(3):292–301.
  2. Lima WG, Silva Alves GC, Sanches C, Antunes Fernandes SO, de Paiva MC. Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: A systematic review and meta-analysis. Burns. 2019;45(7):1495–508.
  3. Hamidian M, Nigro SJ. Emergence, molecular mechanisms and global spread of carbapenem-resistant acinetobacter baumannii. Microb Genomics. 2019;5(10).
  4. Hussain EA, Qasim Hameed H, Mujahid Al-Shuwaikh A, Mujahid Abdullah R. Detection of the aadA1 and aac (3)-1V resistance genes in Acinetobacter baumannii. Arch Razi Inst. 2022;77(3):959–66.
  5. Mcdonnell G, Russell AD. Antiseptics and disinfectants: Activity, action, and resistance. Clin Microbiol Rev. 1999;12(1):147–79.
  6. Correa JE, De Paulis A, Predari S, Sordelli DO, Jeric PE. First report of qacG, qacH and qacJ genes in Staphylococcus haemolyticus human clinical isolates. J Antimicrob Chemother. 2008;62(5):956–60.
  7. Paulsen IT, Littlejohn TG, Radstrom P, Sundstrom L, Skold O, Swedberg G, et al. The 3’ conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Antimicrob Agents Chemother. 1993;37(4):761–8.
  8. Liu WJ, Fu L, Huang M, Zhang JP, Wu Y, Zhou YS, et al. Frequency of antiseptic resistance genes and reduced susceptibility to biocides in carbapenem-resistant Acinetobacter baumannii. J Med Microbiol. 2017;66(1):13–7.
  9. Nima F, Foroughi Borj H, Ziaali N, Tavakoli Kareshk A, Ahmadinejad M, Shafiei R. Genetic Diversity of Toxoplasma gondii by Serological and Molecular Analyzes in Different Sheep and Goat Tissues in Northeastern Iran. Iran J Parasitol. 2023;18(2):217–28.
  10. Moradi J, Hashemi FB, Bahador A. Antibiotic resistance of Acinetobacter baumannii in Iran: A systemic review of the published literature. Osong Public Heal Res Perspect. 2015;6(2):79–86.
  11. Mirzaei B, Bazgir ZN, Goli HR, Iranpour F, Mohammadi F, Babaei R. Prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) phenotypes of Pseudomonas aeruginosa and Acinetobacter baumannii isolated in clinical samples from Northeast of Iran. BMC Res Notes. 2020;13(1):1–6.
  12. Lob SH, Hoban DJ, Sahm DF, Badal RE. Regional differences and trends in antimicrobial susceptibility of Acinetobacter baumannii. Int J Antimicrob Agents. 2016;47(4):317–23.
  13. Moghnieh RA, Kanafani ZA, Tabaja HZ, Sharara SL, Awad LS, Kanj SS. Epidemiology of common resistant bacterial pathogens in the countries of the Arab League. Lancet Infect Dis. 2018;18(12):e379–94.
  14. Abbasi E, Goudarzi H, Hashemi A, Chirani AS, Ardebili A, Goudarzi M, et al. Decreased carO gene expression and OXA-type carbapenemases among extensively drug-resistant Acinetobacter baumannii strains isolated from burn patients in Tehran, Iran. Acta Microbiol Immunol Hung. 2021;68(1):48–54.
  15. Gomaa FAM, Helal ZH, Khan MI. High prevalence of blandm-1, blavim, qace, and qace∆1 genes and their association with decreased susceptibility to antibiotics and common hospital biocides in clinical isolates of acinetobacter baumannii. Microorganisms. 2017;5(2):18.
  16. Guo J, Li C. Molecular epidemiology and decreased susceptibility to disinfectants in carbapenem-resistant Acinetobacter baumannii isolated from intensive care unit patients in central China. J Infect Public Health. 2019;12(6):890–6.
  17. Khosravi AD, Montazeri EA, Maki SR. Antibacterial effects of Octenicept, and benzalkonium chloride on Acinetobacter baumannii strains isolated from clinical samples and determination of genetic diversity of isolates by RAPD-PCR method. Mol Biol Rep. 2021;48(11):7423–31.
  18. Mahzounieh M, Khoshnood S, Ebrahimi A, Habibian S, Yaghoubian M. Detection of antiseptic-resistance genes in Pseudomonas and Acinetobacter spp. isolated from burn patients. Jundishapur J Nat Pharm Prod. 2014;9(2).
  19. Keshavarz-Hedayati S, Shapouri R, Habibollah-Pourzereshki N, Bigverdi R, Peymani A. Molecular Investigation of Resistance to Disinfectants in Acinetobacter Baumannii Isolates Collected From Qazvin Hospitals, Iran (2017). J Qazvin Univ Med Sci. 2019;23(1):2–13.
  20. Vijayakumar R, Sandle T, Al-Aboody MS, AlFonaisan MK, Alturaiki W, Mickymaray S, et al. Distribution of biocide resistant genes and biocides susceptibility in multidrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii — A first report from the Kingdom of Saudi Arabia. J Infect Public Health. 2018;11(6):812–6.
  21. Elkhatib WF, Khalil MAF, Ashour HM. Integrons and Antiseptic Resistance Genes Mediate Resistance of Acinetobacter baumannii and Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients with Wound Infections. Curr Mol Med. 2019;19(4):286–93.
  22. Babaei MR, Sulong A, Hamat RA, Nordin SA, Neela VK. Extremely high prevalence of antiseptic resistant quaternary ammonium compound E gene among clinical isolates of multiple drug resistant acinetobacter baumannii in Malaysia. Ann Clin Microbiol Antimicrob. 2015;14(1):1–5.
  23. Wong MH yin, Chan BK wai, Chan EW chi, Chen S. Over-Expression of ISAba1-Linked Intrinsic and Exogenously Acquired OXA Type Carbapenem-Hydrolyzing-Class D-ß-Lactamase-Encoding Genes Is Key Mechanism Underlying Carbapenem Resistance in Acinetobacter baumannii. Front Microbiol. 2019;10:486957.
  24. Sabbagh P, Rajabnia M, Maali A, Ferdosi-Shahandashti E. Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens. Iran J Basic Med Sci. 2021;24(2):136–42.
  25. Taheri N, Ardebili A, Amouzandeh-Nobaveh A, Ghaznavi-Rad E. Frequency of antiseptic resistance among Staphylococcus aureus and coagulase-negative staphylococci isolated from a university hospital in Central Iran. Oman Med J. 2016;31(6):426–32.
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