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Movahedi, nima, zendehdel, morteza, Vazir, Bita, Hassanpour, Shahin. (1403). Sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken. سامانه مدیریت نشریات علمی, 79(5), 1109-1116. doi: 10.32592/ARI.2024.79.5.1109
nima Movahedi; morteza zendehdel; Bita Vazir; Shahin Hassanpour. "Sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken". سامانه مدیریت نشریات علمی, 79, 5, 1403, 1109-1116. doi: 10.32592/ARI.2024.79.5.1109
Movahedi, nima, zendehdel, morteza, Vazir, Bita, Hassanpour, Shahin. (1403). 'Sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken', سامانه مدیریت نشریات علمی, 79(5), pp. 1109-1116. doi: 10.32592/ARI.2024.79.5.1109
Movahedi, nima, zendehdel, morteza, Vazir, Bita, Hassanpour, Shahin. Sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken. سامانه مدیریت نشریات علمی, 1403; 79(5): 1109-1116. doi: 10.32592/ARI.2024.79.5.1109

Sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken

Archives of Razi Institute
مقاله 29، دوره 79، شماره 5، آذر و دی 2024، صفحه 1109-1116    اصل مقاله (1013.47 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.5.1109
نویسندگان
nima Movahedi1؛ morteza zendehdel* 2؛ Bita Vazir3؛ Shahin Hassanpour4
1Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
3Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Division of PhysiologyDepartment of Basic Sciences Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University-Tehran-Iran
چکیده
This study aimed to determine interaction between muscarinic, NMDA glutamate and glycine receptors on sericin-induced hypophagia in neonatal chicken. This study included 6 experiments with 4 groups in each with 11 repeats for each group. In experiment 1, chicken received ICV injection of the saline, sericin (0.5 n m o l), Telenzepine (M 1 muscarinic receptor antagonist, 125 n m o l), and in group 4 co-injection of the sericin and Telenzepine were applied. In experiments 2-6, chicken received ICV injections of the AF-DX116 (M 2 muscarinic receptor antagonist, 125 n m o l), 4-DAMP (M3 muscarinic receptor antagonist, 125 n m o l), PD102807 (M 4 muscarinic receptor antagonist, 125 nmol), MK-801 (NMDA glutamate receptor antagonist, 15 n m o l), and Strychnine (glycine receptor antagonist, 100 nmol) instead of telenzepine. Then the cumulative food intake was measured at 30, 60 and 120 minutes after the injection. According to the results, ICV injection of the sericin (0.5 n m o l) significantly decreased cumulative food intake comparison to control chicken (P < 0 . 0 5). Co-injection of the telenzepine + sericin significantly decreased sericin induced hypophagia (P < 0.05). Co-injection of the MK - 801 + sericin decreased hypophagic effects of the sericin comparison to control chicken (P < 0. 0 5). Co-injection of the strychnine + sericin decreased hypophagic effects of the sericin comparison to control chicken (P < 0. 05). These findings suggested, sericin-induced hypophagia mediates via M1 muscarinic, NMDA glutamate and glycine receptors in neonatal chicken.
کلیدواژه‌ها
Muscarinic؛ Glutamate؛ Glycine؛ Food intake؛ Chicken
مراجع
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