اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,037
تعداد مقالات33,984
تعداد مشاهده مقاله45,842,539
تعداد دریافت فایل اصل مقاله77,205,544
Sayafi, Mahdi, Pourmoslemi, Shabnam, Moradkhani, Shirin. (1403). Exploring the Chemical Composition and Bioactivity of Lavandula angustifolia Essential Oil: a GC Analysis Approach. سامانه مدیریت نشریات علمی, 14(2), 197-208. doi: 10.22034/jmpb.2024.364861.1655
Mahdi Sayafi; Shabnam Pourmoslemi; Shirin Moradkhani. "Exploring the Chemical Composition and Bioactivity of Lavandula angustifolia Essential Oil: a GC Analysis Approach". سامانه مدیریت نشریات علمی, 14, 2, 1403, 197-208. doi: 10.22034/jmpb.2024.364861.1655
Sayafi, Mahdi, Pourmoslemi, Shabnam, Moradkhani, Shirin. (1403). 'Exploring the Chemical Composition and Bioactivity of Lavandula angustifolia Essential Oil: a GC Analysis Approach', سامانه مدیریت نشریات علمی, 14(2), pp. 197-208. doi: 10.22034/jmpb.2024.364861.1655
Sayafi, Mahdi, Pourmoslemi, Shabnam, Moradkhani, Shirin. Exploring the Chemical Composition and Bioactivity of Lavandula angustifolia Essential Oil: a GC Analysis Approach. سامانه مدیریت نشریات علمی, 1403; 14(2): 197-208. doi: 10.22034/jmpb.2024.364861.1655

Exploring the Chemical Composition and Bioactivity of Lavandula angustifolia Essential Oil: a GC Analysis Approach

Journal of Medicinal plants and By-products
مقاله 11، دوره 14، شماره 2، خرداد و تیر 2025، صفحه 197-208    اصل مقاله (724.96 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.364861.1655
نویسندگان
Mahdi Sayafi1؛ Shabnam Pourmoslemi2؛ Shirin Moradkhani* 1
1Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
This research is a comprehensive study of the chemical composition, antimicrobial, and antioxidant properties of the essential oil derived from Lavandula angustifolia Moench, commonly known as lavender, sourced from the Hamadan province in Iran. The study utilized Gas Chromatography (GC) analysis to scrutinize the chemical composition of the extracted essential oil. Antimicrobial activity was evaluated by determining the minimum inhibitory concentration (MIC) through a series of micro dilutions, while the antioxidant activity was estimated using the DPPH assay. Variations in the chemical composition of the essential oils from the plant’s flowers and leaves were observed, with linalool, linalyl acetate, camphor, and borneol identified as the predominant components in all essential oils. The study revealed significant antimicrobial and antioxidant activities in the essential oil from L. angustifolia. Furthermore, the study further investigated the variations in these properties based on the part of the plant used (leaves or flowers) and the plant’s conditions (purchased or cultivated). The findings indicate that L. angustifolia essential oil holds potential for therapeutic and natural medicine applications.
کلیدواژه‌ها
Lavander؛ Chemical constituents؛ GC-MS analysis؛ DPPH assay؛ Minimum inhibitory concentration
مراجع
  1. Prusinowska R., Śmigielski K.B. Composition, biological properties and therapeutic effects of lavender L). A review. Herba Polonica. 2014;60(2):56-66.
  2. Cavanagh H., Wilkinson J. Biological activities of lavender essential oil. Phytotherapy Res. 2002;16(4):301-8.
  3. Hajhashemi V., Ghannadi A., Pezeshkian S.K. Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. J. Ethnopharmacology. 2002;82(2-3):83-7.
  4. Lis‐Balchin M., Deans S. Bioactivity of selected plant essential oils against Listeria monocytogenes. J. applied microbiology. 1997;82(6):759-62.
  5. Woronuk G., Demissie Z., Rheault M., Mahmoud S. Biosynthesis and therapeutic properties of Lavandula essential oil constituents. Planta medica. 2011;77(01):7-15.
  6. de Rapper S, Kamatou G, Viljoen A, van Vuuren S. The in vitro antimicrobial activity of Lavandula angustifolia essential oil in combination with other aroma-therapeutic oils. Evidence-Based Complementary and Alternative Med. 2013;2013.
  7. Batiha GE.S., Teibo J.O., Wasef L., Shaheen H.M., Akomolafe A.P., Teibo T.K.A., et al. A review of the bioactive components and pharmacological properties of Lavandula species. Naunyn-schmiedeberg's Archives of Pharmacology. 2023;396(5):877-900.
  8. Babaee Khalajee M., Jaimand K., Mozaffari S., Mirshokraie S.A. Comparative study on essential oils of Lavandula officinalis L. from three different sites with different methods of distillation. J. Medicinal Plants and By-Product. 2017;6(1):53-8.
  9. Lis-Balchin M. 8 Naming and misnaming of lavender cultivars. Medicinal and aromatic plants–industrial profiles. 2002:80.
  10. Giray F.H. An analysis of world lavender oil markets and lessons for Turkey. J. Essential Oil Bearing Plants. 2018;21(6):1612-23.
  11. De Sousa D.P., Soares Hocayen Pd.A., Andrade L.N., Andreatini R. A systematic review of the anxiolytic-like effects of essential oils in animal models. Molecules. 2015;20(10):18620-60.
  12. Ayaz M., Sadiq A., Junaid M., Ullah F., Subhan F., Ahmed J. Neuroprotective and anti-aging potentials of essential oils from aromatic and medicinal plants. Frontiers in aging Neuroscience. 2017;9:168.
  13. Taherkhani A., Khamverdi Z., Sayafi M., Moradkhani S. Investigation on Chemical Constituents of Foeniculum vulgare Essential Oil and the Molecular Docking Studies of its Components for Possible Matrix Metalloproteinase-13 Inhibition. Avicenna J. Pharmaceutical Res. 2020;1(2):65-71.
  14. Nikolić M., Jovanović K.K., Marković T., Marković D., Gligorijević N., Radulović S., Soković M. Chemical composition, antimicrobial, and cytotoxic properties of five Lamiaceae essential oils. Industrial Crops and Products. 2014;61:225-32.
  15. Gezici S. Promising anticancer activity of lavender (Lavandula angustifolia Mill.) essential oil through induction of both apoptosis and necrosis. Annals of Phytomedicine. 2018;7(2):38-45.
  16. Garzoli S., Turchetti G., Giacomello P., Tiezzi A., Laghezza Masci V., Ovidi E. Liquid and vapour phase of lavandin (Lavandula× intermedia) essential oil: Chemical composition and antimicrobial activity. Molecules. 2019;24(15):2701.
  17. Boukhatem M.N., Sudha T., Darwish N.H., Chader H., Belkadi A., Rajabi M., et al. A new eucalyptol-rich lavender (Lavandula stoechas L.) essential oil: Emerging potential for therapy against inflammation and cancer. Molecules. 2020;25(16):3671.
  18. Laghezza Masci V, Ovidi E, Taddei AR, Turchetti G, Tiezzi A, Giacomello P, Garzoli S. Apoptotic effects on HL60 human leukaemia cells induced by lavandin essential oil treatment. Molecules. 2020;25(3):538.
  19. Abd Rashed A., Rathi D-N.G., Ahmad Nasir N.A.H., Abd Rahman A.Z. Antifungal properties of essential oils and their compounds for application in skin fungal infections: Conventional and nonconventional approaches. Molecules. 2021;26(4):1093.
  20. Momtaz H.E., Moradkhan S., Alikhani M.Y., Esnaashari F., Afkhami M. Study of antimicrobial effect of some plants of Lamiaceae family on Escherichia coli species isolated from children with urinary tract infection. J. Renal Injury Prevention. 2018;8(1):38-43.
  21. Bikmoradi A., Khaleghverdi M., Seddighi I., Moradkhani S., Soltanian A., Cheraghi F. Effect of inhalation aromatherapy with lavender essence on pain associated with intravenous catheter insertion in preschool children: a quasi-experimental study. Complementary Therapies in Clinical Practice. 2017;28:85-91.
  22. Tavakoli M.M., Davari B., Nasirian H., Salehzadeh A., Moradkhani S., Zahirnia A.H. Investigation of insecticidal properties of Rosmarinus officinalis L. and Lavandula angustifolia Mill. essential oils against German cockroach in laboratory conditions. KAUMS J. (FEYZ). 2021;25(3):994-1002.
  23. Ahmadi M.S., Alipour M., Poorolajal J., Moradkhani S., Akbarpour M. Assessment of the effect of aromatherapy with lavender and chamomile essential oils on postadenotonsillectomy pain in paediatric patients: double blind, randomised clinical trial. J. Herbal Medicine. 2023;41:100728.
  24. Aprotosoaie A.C., Gille E., Trifan A., Luca V.S., Miron A. Essential oils of Lavandula genus: a systematic review of their chemistry. Phytochemistry Reviews. 2017;16:761-99.
  25. Cseke L.J., Kaufman P.B., Kirakosyan A., Warber S., Duke J., Brielmann H. Regulation of metabolite synthesis in plants. Natural products from plants, CRC Press, Boca Raton, FL. 2006:101-41.
  26. Hanamanthagouda M.S., Kakkalameli S.B., Naik P.M., Nagella P., Seetharamareddy HR, Murthy HN. Essential oils of Lavandula bipinnata and their antimicrobial activities. Food Chem. 2010;118(3):836-9.
  27. Mehrabi A., Mahmoudi R., Khedmati Morasa H., Mosavi S., Kazeminia M., Attaran Rezaei F., et al. Study of chemical composition, antibacterial and antioxidant activity of thyme leaves and stems essential oil. Journal of Medicinal plants and By-product. 2022;11(2):253-63.
  28. Bungau A.F., Radu A-F., Bungau S.G., Vesa C.M., Tit D.M., Purza A.L., Endres L.M. Emerging Insights into the Applicability of Essential Oils in the Management of Acne Vulgaris. Molecules. 2023;28(17):6395.
  29. Mojab F., Khalaj N. Chemical Constituents of the Essential Oil of Stachys fruticulosa M. Bieb. From Iran. Avicenna J. Pharmaceutical Res. 2020;1(1):33-6.
  30. Bahramloo M., Moradkhani S., Sedaghat Hamedani M. Phytochemical evaluation and antioxidant effects of the essential oil and distillates of Nepeta crispa Willd. Journal of Medicinal Plants. 2023;22(86):27-43.
  31. Motaghed M., Nili-Ahmadabadi A., Moradkhani S. Assessment of the anti-oxidative potential of Nepeta crispa Willd.(Lamiaceae) and its effects on oxidative stability of virgin sunflower oil under accelerated storage conditions. J. Medicinal Plants. 2022;21(82):13-27.
  32. Novick Jr W.J. Development of in vitro susceptibility testing criteria and quality control parameters. Elsevier; 1989. p. 60-2.
  33. Pappas R.S., Sheppard-Hanger S. Essential oil of Eucalyptus camaldulensis Dehn. from south Florida: A high cryptone/low cineole eucalyptus. J. Essential Oil Res. 2000;12(3):383-4.
  34. Sriramavaratharajan V., Sudha V., Murugan R. Characterization of the leaf essential oils of an endemic species Cinnamomum perrottetii from Western Ghats, India. Natural Product Research. 2016;30(9):1085-7.
  35. Verma RS, Padalia RC, Goswami P, Verma SK, Chauhan A, Singh VR, Darokar MP. Chemical composition and antibacterial activity of p-menthane chemotype of Cymbopogon martini (Roxb.) W. Watson (Poaceae) from India. J. EssEntial oil rEsEarch. 2018;30(3):182-8.
  36. Xu L., Lou Q., Cheng C., Lu M., Sun J. Gut-associated bacteria of Dendroctonus valens and their involvement in verbenone production. Microbial Ecology. 2015;70:1012-23.
  37. Hritcu L., Boiangiu R.S., de Morais M.C., de Sousa D.P. (-)-cis-Carveol, a natural compound, improves β-amyloid-peptide 1-42-induced memory impairment and oxidative stress in the rat hippocampus. BioMed Res. Int. 2020;2020.
  38. Reinhardt R., Steinborn A., Engewald W., Anhalt K., Schulze K. Enantiomer separation of α-campholene and fecholene derivatives by capillary gas chromatography on permethylated cyclodextrin phases I. Compounds separable with single columns. J. Chromatography A. 1995;697(1-2):475-84.
  39. Miyaji H., Satoh K., Kamigaito M. Bio‐Based polyketones by selective ring‐opening radical polymerization of α‐pinene‐derived pinocarvone. Angewandte Chemie International Edition. 2016;55(4):1372-6.
  40. Feng Y-X., Zhang X., Wang Y., Chen Z-Y., Lu X-X., Du Y-S., Du S-S. The potential contribution of cymene isomers to insecticidal and repellent activities of the essential oil from Alpinia zerumbet. International Biodeterioration & Biodegradation. 2021;157:105138.
  41. Maisonnasse A., Lenoir J-C., Beslay D., Crauser D., Le Conte Y. E-β-ocimene, a volatile brood pheromone involved in social regulation in the honey bee colony (Apis mellifera). PLoS One. 2010;5(10):e13531.
  42. Amiri H. Volatile constituents and antioxidant activity of flowers, stems and leaves of Nasturtium officinale R. Br. Natural Product Res. 2012;26(2):109-15.
  43. Kundu A., Saha S., Walia S., Ahluwalia V., Kaur C. Antioxidant potential of essential oil and cadinene sesquiterpenes of Eupatorium adenophorum. Toxicological & Environmental Chem. 2013;95(1):127-37.
  44. Stolle A. Synthesis of Nopinone from β‐Pinene–A Journey Revisiting Methods for Oxidative Cleavage of C= C Bonds in Terpenoid Chemistry. European J. Organic Chem. 2013;2013(12):2265-78.
  45. Smaili T., Bendif H., Zedam A., Flamini G., Maggi F. A new chemotype with high tricyclene content from the essential oil of Salvia aegyptiaca L. growing in Algerian Pre-Sahara. Natural Product Res. 2022;36(20):5364-9.
  46. González-Rivera J., Duce C., Falconieri D., Ferrari C., Ghezzi L., Piras A., Tine M.R. Coaxial microwave assisted hydrodistillation of essential oils from five different herbs (lavender, rosemary, sage, fennel seeds and clove buds): Chemical composition and thermal analysis. Innovative Food Sci. Emerging Technol. 2016;33:308-18.
  47. Muñoz-Bertomeu J., Arrillaga I., Segura J. Essential oil variation within and among natural populations of Lavandula latifolia and its relation to their ecological areas. Biochemical Systematics and Ecology. 2007;35(8):479-88.
  48. Guitton Y., Nicolè F., Moja S., Valot N., Legrand S., Jullien F., Legendre L. Differential accumulation of volatile terpene and terpene synthase mRNAs during lavender (Lavandula angustifolia and L. x intermedia) inflorescence development. Physiologia Plantarum. 2010;138(2):150-63.
  49. Harborne JB, Williams CA. Phytochemistry of the genus Lavandula. Lavender. 2002:100-13.
  50. Da Porto C., Decorti D., Kikic I. Flavour compounds of Lavandula angustifolia L. to use in food manufacturing: Comparison of three different extraction methods. Food Chem. 2009;112(4):1072-8.
  51. Dušková E., Dušek K., Indrák P., Smékalová K. Postharvest changes in essential oil content and quality of lavender flowers. Industrial Crops and Products. 2016;79:225-31.
  52. Babu G.K., Thakur V., Singh B. Variability in the composition of Lavandula angustifolia extracts due to extraction methods. J. Herbs, Spices & Medicinal Plants. 2016;22(2):173-82.
  53. Dobros N., Zawada K., Paradowska K. Phytochemical Profile and Antioxidant Activity of Lavandula angustifolia and Lavandula x intermedia Cultivars Extracted with Different Methods. Antioxidants. 2022;11(4):711.
  54. Smigielski K., Prusinowska R., Stobiecka A., Kunicka-Styczyñska A., Gruska R. Biological properties and chemical composition of essential oils from flowers and aerial parts of lavender (Lavandula angustifolia). J. Essential Oil Bearing Plants. 2018;21(5):1303-14.
  55. Hassanpouraghdam M.B., Hassani A., Vojodi L., Asl B.H., Rostami A. Essential oil constituents of Lavandula officinalis Chaix. from Northwest Iran. Chemija. 2011;22(3):167-71.
  56. Dong G., Bai X., Aimila A., Aisa H.A., Maiwulanjiang M. Study on lavender essential oil chemical compositions by GC-MS and improved pGC. Molecules. 2020;25(14):3166.
  57. Fadia A., Al–Naser Z., Al-Hakim W. Chemical composition of Lavandula angustifolia Miller and Rosmarinus officinalis L. essential oils and fumigant toxicity against larvae of Ephestia kuehniella Zeller. Int. J. Chem. Technol. Res. 2015;8:1382-90.
  58. Chen X., Zhang L., Qian C., Du Z., Xu P., Xiang Z. Chemical compositions of essential oil extracted from Lavandula angustifolia and its prevention of TPA-induced inflammation. Microchemical J. 2020;153:104458.
  59. Danh L.T., Han L.N., Triet N.D.A., Zhao J., Mammucari R, Foster N. Comparison of chemical composition, antioxidant and antimicrobial activity of lavender (Lavandula angustifolia L.) essential oils extracted by supercritical CO 2, hexane and hydrodistillation. Food and Bioprocess Technology. 2013;6:3481-9.
  60. Biswas K.K., Foster A.J., Aung T., Mahmoud S.S. Essential oil production: relationship with abundance of glandular trichomes in aerial surface of plants. Acta physiologiae Plantarum. 2009;31:13-9.
  61. Garzoli S., Laghezza Masci V., Franceschi S., Tiezzi A., Giacomello P., Ovidi E. Headspace/GC–MS analysis and investigation of antibacterial, antioxidant and cytotoxic activity of essential oils and hydrolates from Rosmarinus officinalis L. and Lavandula angustifolia Miller. Foods. 2021;10(8):1768.
  62. Miliauskas G., Venskutonis P., Van Beek T. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 2004;85(2):231-7.
  63. Nikšić H., Kovač-Bešović E., Makarević E., Durić K., Kusturica J., Muratovic S. Antiproliferative, antimicrobial, and antioxidant activity of Lavandula angustifolia Mill. essential oil/H. Nikšić, E Kovač-Bešović, E Makarevic, K Durić, J Kusturica, S Muratovic. J. Health Sci. 2017(7):35-43.
  64. Inouye S., Takizawa T., Yamaguchi H. Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. J. Antimicrobial Chemotherapy. 2001;47(5):565-73.
  65. Ciocarlan A., Lupascu L., Aricu A., Dragalin I., Popescu V., Geana E-I., et al. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. Plants. 2021;10(9):1829.
  66. Tamri P., Pourmoslemi S., Moradkhani S., Foroughinia S. Evaluation of synergistic antibacterial effect of combined Scrophularia striata extract and antibiotics against Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus. Iraqi J. Pharmaceutical Science. 2021;30(2):219-24.
آمار
تعداد مشاهده مقاله: 229
تعداد دریافت فایل اصل مقاله: 394


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب