اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,909
تعداد مقالات32,812
تعداد مشاهده مقاله43,136,221
تعداد دریافت فایل اصل مقاله19,709,529
Nowrozi, Azam, Johari, Habibolla, Shariati, Mehrdad. (1403). Exploring Combinatorial Therapies: Betanin (Beetroot by-products), Vitamin E, and Vitamin D3 Interactions in Ameliorating Penconazole-Induced Testicular Changes and Hormonal Disruptions in Rats. سامانه مدیریت نشریات علمی, 14(2), 189-196. doi: 10.22034/jmpb.2024.365812.1693
Azam Nowrozi; Habibolla Johari; Mehrdad Shariati. "Exploring Combinatorial Therapies: Betanin (Beetroot by-products), Vitamin E, and Vitamin D3 Interactions in Ameliorating Penconazole-Induced Testicular Changes and Hormonal Disruptions in Rats". سامانه مدیریت نشریات علمی, 14, 2, 1403, 189-196. doi: 10.22034/jmpb.2024.365812.1693
Nowrozi, Azam, Johari, Habibolla, Shariati, Mehrdad. (1403). 'Exploring Combinatorial Therapies: Betanin (Beetroot by-products), Vitamin E, and Vitamin D3 Interactions in Ameliorating Penconazole-Induced Testicular Changes and Hormonal Disruptions in Rats', سامانه مدیریت نشریات علمی, 14(2), pp. 189-196. doi: 10.22034/jmpb.2024.365812.1693
Nowrozi, Azam, Johari, Habibolla, Shariati, Mehrdad. Exploring Combinatorial Therapies: Betanin (Beetroot by-products), Vitamin E, and Vitamin D3 Interactions in Ameliorating Penconazole-Induced Testicular Changes and Hormonal Disruptions in Rats. سامانه مدیریت نشریات علمی, 1403; 14(2): 189-196. doi: 10.22034/jmpb.2024.365812.1693

Exploring Combinatorial Therapies: Betanin (Beetroot by-products), Vitamin E, and Vitamin D3 Interactions in Ameliorating Penconazole-Induced Testicular Changes and Hormonal Disruptions in Rats

Journal of Medicinal plants and By-Products
مقاله 10، دوره 14، شماره 2، خرداد و تیر 2025، صفحه 189-196    اصل مقاله (1.45 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.365812.1693
نویسندگان
Azam Nowrozi1؛ Habibolla Johari* 2؛ Mehrdad Shariati1
1Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2Department of Biology, Darab Branch, Islamic Azad University, Darab, Iran
چکیده
Spermatogenesis, a complex process, is influenced by factors including hormonal regulation, environmental exposures, nutritional deficiencies, and genetic abnormalities. Disruptions in hormonal balance can adversely affect sperm production, leading to idiopathic infertility, which constitutes a significant proportion of male infertility cases. Environmental toxins such as pesticides pose a threat to male reproductive health by disrupting the hypothalamic-pituitary-gonadal axis and impairing spermatogenesis. Penconazole, a systemic triazole fungicide widely used in agriculture, has been associated with reproductive toxicity and oxidative stress-induced testicular damage. Antioxidant-rich compounds like betanin, extracted from beets, and micronutrients like vitamin E and vitamin D3 have shown potential in mitigating oxidative stress and enhancing male reproductive function. This study aims to evaluate and compare the efficacy of betanin, vitamin E, and D3, individually and in combination, in mitigating alterations in testicular tissue morphology and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone in rats exposed to penconazole. Thirty-six adult Wistar rats were randomly assigned to six groups and subjected to various treatments for twenty-eight days. Blood samples were collected for hormone quantification, and histological studies were conducted on testicular tissue specimens. Statistical analysis revealed significant disparities in hormone levels among experimental groups, with betanin, vitamin E, and vitamin D3 showing efficacy in mitigating penconazole-induced spermatotoxicity and testicular damage. These findings underscore the potential therapeutic efficacy of betanin, vitamin E, and vitamin D3 in preserving male reproductive health and mitigating the adverse effects of environmental toxins on spermatogenesis. Further research is warranted to elucidate the precise mechanisms of action and therapeutic potential of these compounds in male infertility management and environmental toxicology.
کلیدواژه‌ها
Environmental toxins؛ Hormonal regulation؛ Male infertility؛ Penconazole؛ Spermatogenesis
مراجع
  1. Holdcraft R.W., Braun R.E. Hormonal regulation of spermatogenesis. International J. andrology. 2004;27(6):335-42.
  2. Sharpe RM. Environmental/lifestyle effects on spermatogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences. 2010;365(1546):1697-712.
  3. Massart A., Lissens W., Tournaye H., Stouffs K. Genetic causes of spermatogenic failure. Asian J. Andrology. 2012;14(1):40.
  4. Semet M., Paci, Saïas‐Magnan M., Metzler‐Guillemain J., Boissier C., Lejeune R., Perrin, J. The impact of drugs on male fertility: a review. Andrology. 2017;5(4):640-63.
  5. Seshagiri P.B. Molecular insights into the causes of male infertility. Journal of biosciences. 2001;26:429-35.
  6. Pan J., Liu P., Yu X., Zhang Z., Liu J. The adverse role of endocrine disrupting chemicals in the reproductive system. Frontiers in Endocrinology. 2024;14:1324993.
  7. Xie Y., Holmgren S., Andrews D.M., Wolfe M.S. Evaluating the impact of the US National toxicology program: A case study on hexavalent chromium. Environmental health perspectives. 2017;125(2):181-8.
  8. Zeliger H. Human toxicology of chemical mixtures: William Andrew; 2011.
  9. Chambers J.E., Greim H., Kendall R.J., Segner H., Sharpe R.M., Van Der Kraak G. Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole. Critical reviews in toxicology. 2014;44(2):176-210.
  10. Chaâbane M., Tir M., Hamdi S., Boudawara O., Jamoussi K., Boudawara T., Ghorbel R.E., Zeghal N., Soudani N. Improvement of heart redox states contributes to the beneficial effects of selenium against penconazole-induced cardiotoxicity in adult rats. Biological trace element research. 2016;169:261-70.
  11. Chaâbane M., Ghorbel I., Elwej A., Mnif H., Boudawara T., Chaâbouni S.E., Zeghal N., Soudani N. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Human & experimental toxicology. 2017;36(8):854-66.
  12. Shaki F., Ebrahimzadeh Maboud H., Niknam V. Penconazole alleviates salt-induced damage in safflower (Carthamus tinctorius L.) plants. Journal of Plant Interactions. 2018;13(1):420-7.
  13. Maretta M., Marettová E., Legáth J. The effect of conazoles on reproductive organs structure and function–a review. Acta Veterinaria Brno. 2023;92(1):61-8.
  14. Johari H., Parhizkar Z., Talebi E. Effects of adenine on the pituitary-gonad axis in newborns rats. Pakistan Journal of Biological Sciences: PJBS. 2008;11(20):2413-7.
  15. Talebi E., Rowghani Fard E., Navabi M., Eatemadi M. Evaluating the effect of two types of thyme essential oils (Zataria multiflora & Ziziphora clinopodioides Lam) on some productive traits and blood parameters in broilers. 2021.
  16. Thiruvengadam M., Chung I.M., Samynathan R., Chandar S.H., Venkidasamy B., Sarkar T., Rebezov M., Gorelik O., Shariati M.A., Simal-Gandara J. A comprehensive review of beetroot (Beta vulgaris L.) bioactive components in the food and pharmaceutical industries. Critical Reviews in Food Science and Nutrition. 2024;64(3):708-39.
  17. Silva D.V.Td., Baiao Dd.S., Ferreira V.F., Paschoalin V.M.F. Betanin as a multipath oxidative stress and inflammation modulator: A beetroot pigment with protective effects on cardiovascular disease pathogenesis. Critical Reviews in Food Science and Nutrition. 2021;62(2):539-54.
  18. Cito G., Cocci A., Micelli E., Gabutti A., Russo G.I., Coccia M.E., Franco G., Serni S., Carini M., Natali A. Vitamin D and male fertility: an updated review. The world journal of men's health. 2020;38(2):164.
  19. Mutalip S.S.M. Vitamin E and reproductive health. Molecular Nutrition: Elsevier; 2020. p. 543-59.
  20. Sarangi A., Verma A., Patel R., Rath A., Sahu S., Virmani M., Devi P. Vitamin E and gluthathion as antioxidant in liquid preservation of semen: A review. International Journal of Current Microbiology and Applied Science. 2018;7(4):1680-4.
  21. Bansal A.K., Kaushik K. Role of oxidative stress, reactive oxygen species & antioxidants in male reproductive functions. Theriogenology Insight-An International Journal of Reproduction in all Animals. 2019;9(1):35-45.
  22. Jeremy M., Gurusubramanian G., Roy V.K. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model. The Journal of Steroid Biochemistry and Molecular Biology. 2019;190:64-75.
  23. Ciccone I.M., Costa E.M., Pariz J.R., Teixeira T.A., Drevet J.R., Gharagozloo P., Aitken R.J., Hallak J. Serum vitamin D content is associated with semen parameters and serum testosterone levels in men. Asian journal of andrology. 2021;23(1):52-8.
  24. Serdar C.C., Cihan M., Yücel D., Serdar M.A. Sample size, power and effect size revisited: simplified and practical approaches in preclinical, clinical and laboratory studies. Biochemia medica. 2021;31(1):27-53.
  25. Sun W., Bi L.K., Xie D.D., Yu D.X. Serum nesfatin‐1 is associated with testosterone and the severity of erectile dysfunction. Andrologia. 2020;52(7):e13634.
  26. Talebi E., Ghazanfarpour H., Ghazanfarpoor R., Bouchentouf S., Khosravinezhad M. Application of selenium nanoparticles on sperm quantity indicators in wistar rat. Nephro-Urology Monthly. 2021;13(2).
  27. Lushchak V.I., Matviishyn T.M., Husak V.V., Storey J.M., Storey K.B. Pesticide toxicity: a mechanistic approach. EXCLI journal. 2018;17:1101.
  28. Huang T., Zhao Y., He J., Cheng H., Martyniuk C.J. Endocrine disruption by azole fungicides in fish: A review of the evidence. Science of the Total Environment. 2022;822:153412.
  29. Borai I.H., Atef A.A., El-Kashoury A.A., Mohamed R.A., Said M.M. Ameliorative effects of sesame seed oil against penconazole-induced testicular toxicity and endocrine disruption in male rats. Biomed J. Sci. Tech. Res. 2019;14(1):10365-75.
  30. El-Sharkawy E.E., El-Nisr N.A. Testicular dysfunction induced by penconazole fungicide on male albino rats. Comparative Clinical Pathology. 2013;22:475-80.
  31. Lv X., Pan L., Wang J., Lu L., Yan W., Zhu Y., Xu Y., Guo M., Zhuang S. Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity. Environmental pollution. 2017;222:504-12.
  32. Hadipour E., Fereidoni M., Tayarani-Najaran Z. Betanin attenuates oxidative stress induced by 6-OHDA in PC12 cells via SAPK/JNK and PI3 K pathways. Neurochemical Research. 2020;45:395-403.
  33. da Silva D.V.T., Pereira A.D.A., Boaventura G.T., Ribeiro R.Sd.A., Verícimo M.A., Carvalho-Pinto C.Ed., Baião D.D., Del Aguila E.M., Paschoalin V.M. Short-term betanin intake reduces oxidative stress in wistar rats. Nutrients. 2019;11(9):1978.
  34. Nobari H., Kargarfard M., Minasian V., Cholewa J.M., Pérez-Gómez J. The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: A double blind, randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition. 2021;18(1):20.
  35. Arazi H., Aboutalebi S., Taati B., Cholewa J.M., Candow D.G. Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes. Journal of the International Society of Sports Nutrition. 2022;19(1):1-16.
  36. Di Renzo L., De Lorenzo A., Fontanari M., Gualtieri P., Monsignore D., Schifano G., Alfano V., Marchetti M., SIERR. Immunonutrients involved in the regulation of the inflammatory and oxidative processes: implication for gamete competence. Journal of Assisted Reproduction and Genetics. 2022;39(4):817-46.
  37. Teleanu D.M., Niculescu A.G., Lungu I.I., Radu C.I., Vladâcenco O., Roza E., Costăchescu B., Grumezescu A.M., Teleanu R.I. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. International Journal of Molecular Sciences. 2022;23(11):5938.
  38. Grzesiak M., Tchurzyk M., Socha M., Sechman A., Hrabia A. An overview of the current known and unknown roles of vitamin d3 in the female reproductive system: Lessons from farm animals, birds, and fish. International Journal of Molecular Sciences. 2022;23(22):14137.
  39. Sharma R., Martins N., Kuca K., Chaudhary A., Kabra A., Rao M.M., Prajapati P.K. Chyawanprash: A traditional indian bioactive health supplement. Biomolecules. 2019;9(5):161.
  40. Kim H.K., Han S.N. Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles. IUBMB Life. 2019;71(4):442-55.
  41. Chen X., Yang S., Zhu B., Zhang M., Zheng N., Hua J., Li R., Han J., Yang L., Zhou B. Effects of environmentally relevant concentrations of niclosamide on lipid metabolism and steroid hormone synthesis in adult female zebrafish. Science of The Total Environment. 2024;910:168737.
  42. Safarinejad M.R., Safarinejad S., Shafiei N., Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. The Journal of urology. 2012;188(2):526-31.
  43. Blomberg Jensen M., Nielsen J.E., Jørgensen A., Rajpert-De Meyts E., Kristensen D.M., Jørgensen N., Skakkebaek N.E., Juul A., Leffers H. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human reproduction. 2010;25(5):1303-11.
  44. Hasanin N.A., Sayed N.M., Ghoneim F.M., Al-Sherief S.A. Histological and ultrastructure study of the testes of acrylamide exposed adult male albino rat and evaluation of the possible protective effect of vitamin e intake. Journal of Microscopy and Ultrastructure. 2018;6(1):23-34.
  45. Elsheikh N.A.H., Omer N.A., Yi-Ru W., Mei-Qian K., Ilyas A., Abdurahim Y., Wang G.L. Protective effect of betaine against lead-induced testicular toxicity in male mice. Andrologia. 2020;52(7):e13600.
  46. Zamani A., Saki F., Hatami N., Koohpeyma F. Stereological assessment of the effects of vitamin D deficiency on the rat testis. BMC Endocrine Disorders. 2020;20(1):162.
آمار
تعداد مشاهده مقاله: 142
تعداد دریافت فایل اصل مقاله: 125


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب