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Hosseini, Seyedeh Delafruz, Banaee, Mahdis, Yasaghi, Mohammad, Rastegar, Mostafa, Hassanpour, Mina, Kashani, Elham, Sabzi, Zahra, Cools, Piet, Tabarraei, Alijan. (1404). Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan. سامانه مدیریت نشریات علمی, 80(3), 629-637. doi: 10.32592/ARI.2025.80.3.629
Seyedeh Delafruz Hosseini; Mahdis Banaee; Mohammad Yasaghi; Mostafa Rastegar; Mina Hassanpour; Elham Kashani; Zahra Sabzi; Piet Cools; Alijan Tabarraei. "Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan". سامانه مدیریت نشریات علمی, 80, 3, 1404, 629-637. doi: 10.32592/ARI.2025.80.3.629
Hosseini, Seyedeh Delafruz, Banaee, Mahdis, Yasaghi, Mohammad, Rastegar, Mostafa, Hassanpour, Mina, Kashani, Elham, Sabzi, Zahra, Cools, Piet, Tabarraei, Alijan. (1404). 'Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan', سامانه مدیریت نشریات علمی, 80(3), pp. 629-637. doi: 10.32592/ARI.2025.80.3.629
Hosseini, Seyedeh Delafruz, Banaee, Mahdis, Yasaghi, Mohammad, Rastegar, Mostafa, Hassanpour, Mina, Kashani, Elham, Sabzi, Zahra, Cools, Piet, Tabarraei, Alijan. Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan. سامانه مدیریت نشریات علمی, 1404; 80(3): 629-637. doi: 10.32592/ARI.2025.80.3.629

Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan

Archives of Razi Institute
مقاله 11، دوره 80، شماره 3، مرداد و شهریور 2025، صفحه 629-637    اصل مقاله (590.47 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.3.629
نویسندگان
Seyedeh Delafruz Hosseini1؛ Mahdis Banaee2؛ Mohammad Yasaghi1؛ Mostafa Rastegar3؛ Mina Hassanpour3؛ Elham Kashani2؛ Zahra Sabzi4؛ Piet Cools5؛ Alijan Tabarraei* 1
1Infectious Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
2Department of Obstetrics and Gynecology, Golestan University of Medical Sciences, Golestan, Iran
3Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
5Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
چکیده
With the onset of the severe acute respiratory syndrome coronavirus-2 pandemic, there were controversial theories regarding the potential consequences of the virus on pregnant women and delivery outcomes. During the past three years, a great diversity of literature reported various data regarding covid-infected mothers and pregnancy-related complications including preterm birth, stillbirth, preeclampsia, cesarean delivery, etc., however; the exact influences which can be exerted by the virus and possibility of vertical transmission, still remained obscure. Here we described the clinical features and outcomes of delivery in 16 laboratory confirmed COVID-19-infected mothers referring to a hospital in northern Iran from August 2020 to December 2021. Clinical records, laboratory results, and chest CT scans in addition to such samples as maternal peripheral blood, umbilical cord blood, placental blood, vaginal secretion, placental tissue, breast milk after first lactation, and neonatal throat swab and peripheral blood were collected to answer the questions raised on the possibility of vertical transmission of COVID-19 and transferring maternal immunity to the neonates, all the aforementioned specimen were evaluated based on molecular and serological assays. SARS-CoV-2 RNA was not detected in vaginal secretions and placental tissue. SARS-CoV-2 IgG and IgM antibodies were detected in 15 and 4 maternal blood samples, respectively; in one breast milk sample (IgM), two umbilical cord blood (IgG) samples, two placental blood (IgG) and two neonatal blood (IgG) samples. Chest CT scan of abnormal cases revealed typical signs of viral pneumonia. According to the current study there seems to be associations between SARS-CoV-2 infection and the risk of preterm birth; however, no intrauterine vertical transmission of SARS-CoV-2 was found. These results also suggest the possibility of passive IgG transfer from the infected mothers to their neonates.
کلیدواژه‌ها
COVID-19؛ Pregnancy؛ Infectious Disease Transmission؛ Vertical؛ Iran
مراجع
  1. Smith ER, Oakley E, Grandner GW, Ferguson K, Farooq F, Afshar Y, et al. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health. 2023;8(1).
  2. Ryan EE, Brar N, Allard G, Wang A, Winn VD, Folkins A, et al. Clinical Features of SARS-CoV-2 Infection During Pregnancy and Associated Placental Pathologies. International Journal of Gynecological Pathology. 2024;43(1):15-24.
  3. McClymont E, Albert AY, Alton GD, Boucoiran I, Castillo E, Fell DB, et al. Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes. JAMA. 2022;327(20):1983-91.
  4. Manti S, Leonardi S, Rezaee F, Harford TJ, Perez MK, Piedimonte G. Effects of Vertical Transmission of Respiratory Viruses to the Offspring. Frontiers in Immunology. 2022;13.
  5. Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational pediatrics. 2020;9(1):51.
  6. Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, et al. Assessment of maternal and neonatal cord blood SARS-CoV-2 antibodies and placental transfer ratios. JAMA pediatrics. 2021;175(6):594-600.
  7. Shook LL, Collier A-RY, Goldfarb IT, Diouf K, Akinwunmi BO, Young N, et al. Vertical transmission of SARS-CoV-2: consider the denominator. American Journal of Obstetrics & Gynecology MFM. 2021;3(4).
  8. Garcia-Ruiz I, Sulleiro E, Serrano B, Fernandez-Buhigas I, Rodriguez-Gomez L, Fernandez DS-N, et al. Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study. Clinical Microbiology and Infection. 2021;27(10):1521. e1-. e5.
  9. Constantino FB, Cury SS, Nogueira CR, Carvalho RF, Justulin LA. Prediction of non-canonical routes for SARS-CoV-2 infection in human placenta cells. Frontiers in Molecular Biosciences. 2021;8.
  10. Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review. The journal of maternal-fetal & neonatal medicine. 2022;35(8):1619-22.
  11. Conde-Agudelo A, Romero R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. American journal of obstetrics and gynecology. 2022;226(1):68-89. e3.
  12. Serrano B, Bonacina E, Garcia-Ruiz I, Mendoza M, Garcia-Manau P, Garcia-Aguilar P, et al. Confirmation of preeclampsia-like syndrome induced by severe COVID-19: an observational study. American Journal of Obstetrics & Gynecology MFM. 2023;5(1):100760.
  13. Sánchez-Ortega H, Jiménez-Cortegana C, Novalbos-Ruiz JP, Gómez-Bastero A, Soto-Campos JG, Sánchez-Margalet V. Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2023;24(1):546.
  14. Langel SN, Blasi M, Permar SR. Maternal immune protection against infectious diseases. Cell Host & Microbe. 2022;30(5):660-74.
  15. Fenizia C, Biasin M, Cetin I, Vergani P, Mileto D, Spinillo A, et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nature communications. 2020;11(1):5128.
  16. Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. Jama. 2020;323(18):1848-9.
  17. Helguera-Repetto AC, Villegas-Mota I, Arredondo-Pulido GI, Cardona–Pérez JA, León-Juárez M, Rivera-Rueda MA, et al. Cord blood SARS-CoV-2 IgG antibodies and their association with maternal immunity and neonatal outcomes. Frontiers in pediatrics. 2022;10.
  18. Gill L, Jones CW. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in neonatal cord blood after vaccination in pregnancy. Obstetrics & Gynecology. 2021;137(5):894-6.
  19. Nicolaidou V, Georgiou R, Christofidou M, Felekkis K, Pieri M, Papaneophytou C. Detection of SARS-CoV-2–Specific Antibodies in Human Breast Milk and Their Neutralizing Capacity after COVID-19 Vaccination: A Systematic Review. International Journal of Molecular Sciences. 2023;24(3):2957.
  20. Sajadi MM, Shokatpour N, Purcell M, Tehrani ZR, Lankford A, Bathula A, et al. Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding. Plos one. 2023;18(4):e0284020.
  21. Peng S, Zhu H, Yang L, Cao L, Huang X, Dynes M, et al. A study of breastfeeding practices, SARS-CoV-2 and its antibodies in the breast milk of mothers confirmed with COVID-19. The Lancet Regional Health-Western Pacific. 2020;4:100045.
  22. Lin Q, Zhu L, Ni Z, Meng H, You L. Duration of serum neutralizing antibodies for SARS-CoV-2: Lessons from SARS-CoV infection. Journal of microbiology, immunology, and infection. 2020;53(5):821.
  23. Centeno‐Tablante E, Medina‐Rivera M, Finkelstein JL, Rayco‐Solon P, Garcia‐Casal MN, Rogers L, et al. Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review. Annals of the New York Academy of Sciences. 2021;1484(1):32-54.
  24. Jafari M, Pormohammad A, Sheikh Neshin SA, Ghorbani S, Bose D, Alimohammadi S, et al. Clinical characteristics and outcomes of pregnant women with COVID‐19 and comparison with control patients: A systematic review and meta‐analysis. Reviews in medical virology. 2021;31(5):1-16.
  25. Wong YP, Khong TY, Tan GC. The effects of COVID-19 on placenta and pregnancy: what do we know so far? Diagnostics. 2021;11(1):94.
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