اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها3,005
تعداد مقالات33,631
تعداد مشاهده مقاله44,472,450
تعداد دریافت فایل اصل مقاله29,935,040
Hosseini, Amirhossein, Abdolmaleki, Arash, Nahumi, Aida, asadi, asadollah, Ghanimi, Hussein A.. (1404). Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering. سامانه مدیریت نشریات علمی, 80(2), 413-424. doi: 10.32592/ARI.2025.80.2.413
Amirhossein Hosseini; Arash Abdolmaleki; Aida Nahumi; asadollah asadi; Hussein A. Ghanimi. "Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering". سامانه مدیریت نشریات علمی, 80, 2, 1404, 413-424. doi: 10.32592/ARI.2025.80.2.413
Hosseini, Amirhossein, Abdolmaleki, Arash, Nahumi, Aida, asadi, asadollah, Ghanimi, Hussein A.. (1404). 'Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering', سامانه مدیریت نشریات علمی, 80(2), pp. 413-424. doi: 10.32592/ARI.2025.80.2.413
Hosseini, Amirhossein, Abdolmaleki, Arash, Nahumi, Aida, asadi, asadollah, Ghanimi, Hussein A.. Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering. سامانه مدیریت نشریات علمی, 1404; 80(2): 413-424. doi: 10.32592/ARI.2025.80.2.413

Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

Archives of Razi Institute
مقاله 6، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 413-424    اصل مقاله (579.4 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.2.413
نویسندگان
Amirhossein Hosseini1؛ Arash Abdolmaleki2؛ Aida Nahumi1؛ asadollah asadi* 3؛ Hussein A. Ghanimi4
1Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
2Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
3Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
4Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Karbala, Iraq.
چکیده
Mesenchymal stem cells (MSCs) have been shown to possess immunomodulatory properties that can regulate the immune response and promote tissue regeneration. These properties include the ability to suppress T cell proliferation, modulate macrophage polarization, and promote regulatory T cell differentiation. Suffice it to say that natural chemoattraction pathways can attract MSCs; these cells are created from around the injured tissues, creating a repair/regenerative microenvironment for this study. The speed of regeneration of tissue damage depends on the person's age, level of tissue damage, and also depends on which part of the body is damaged. It can be seen that the manipulation of mesenchymal stem cells can have very significant effects on the rate of tissue damage, tissue regeneration, and also cell death. Immunosuppressive and trophic mechanism influences are different from the mechanisms that are being led by tissue engineering to replace the special mesenchymal tissues. In fact, it can be seen how tissue engineering processes get along with trophic to promote astonishing tissue regeneration and support the smooth integration of newly created tissue into the body. MSCs have been worked on for more than 20 years and their potential has been just realized for clinical applications. It is obvious that the usage of MSCs for tissue engineering requires quite different reasons than their usage in nutritional and immunomodulatory functions. These latter efforts now appear to apply to the clinic before tissue engineering methods become feasible. The findings of this study reveal that MSCs have the ability to differentiate into various cell types, which makes them an ideal candidate for treating a wide range of human diseases.
کلیدواژه‌ها
Keywords: Macrophage؛ Immunomodulation؛ Mesenchymal stem cells؛ Bone Marrow؛ Tissue engineering
مراجع
  1. Abdolmaleki A, Ghanimi HA, Asadi A, Taghizadeh-Momen L. Retracted Article: Preparation of Decellularized Bovine Tendon Scaffold and Evaluation of Its Interaction with Adipose Tissue-Derived Mesenchymal Stem Cells. Gene, Cell and Tissue. 2020;7(2).
  2. Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nature immunology. 2014;15(11):1009-16.
  3. Jurewicz M, Yang S, Augello A, Godwin JG, Moore RF, Azzi J, et al. Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes. Diabetes. 2010;59(12):3139-47.
  4. Xu J-Y, Lee Y-K, Ran X, Liao S-Y, Yang J, Au K-W, et al. Generation of induced cardiospheres via reprogramming of skin fibroblasts for myocardial regeneration. Stem cells. 2016;34(11):2693-706.
  5. Peng Y, Chen X, Liu Q, Zhang X, Huang K, Liu L, et al. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia. 2015;29(3):636-46.
  6. Cipriani P, Carubbi F, Liakouli V, Marrelli A, Perricone C, Perricone R, et al. Stem cells in autoimmune diseases: implications for pathogenesis and future trends in therapy. Autoimmunity reviews. 2013;12(7):709-16.
  7. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of cellular physiology. 2007;213(2):341-7.
  8. Owen M. Marrow stromal stem cells. Journal of cell science. 1988;1988(Supplement_10):63-76.
  9. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5‐azacytidine. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine. 1995;18(12):1417-26.
  10. .
  11. Czerwiec K, Zawrzykraj M, Deptuła M, Skoniecka A, Tymińska A, Zieliński J, et al. Adipose-derived mesenchymal stromal cells in basic research and clinical applications. International Journal of Molecular Sciences. 2023;24(4):3888.
  12. Huang H, Liu X, Wang J, Suo M, Zhang J, Sun T, et al. Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration. Frontiers in Cell and Developmental Biology. 2023;11:1215698.
  13. Costa LA, Eiro N, Vaca A, Vizoso FJ. Towards a new concept of regenerative endodontics based on mesenchymal stem cell-derived secretomes products. Bioengineering. 2022;10(1):4.
  14. Liu N, Cheng Y, Wang D, Guan H, Chen D, Zeng J, et al. Tissue-specific populations from amniotic fluid-derived mesenchymal stem cells manifest variant in vitro and in vivo properties. Human Cell. 2024;37(2):408-19.
  15. Song Y, Li P, Xu Y, Lin Z, Deng Z, Chen C. Menstrual Blood–Derived Mesenchymal Stem Cells Encapsulated in Autologous Platelet-Rich Gel Facilitate Rotator Cuff Healing in a Rabbit Model of Chronic Tears. The American Journal of Sports Medicine. 2023;51(7):1872-85.
  16. Chakraborty S, Bhattacharyya R, Banerjee D. Infections: a possible risk factor for type 2 diabetes. Advances in clinical chemistry. 2017;80:227-51.
  17. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. The Lancet. 2008;371(9624):1579-86.
  18. Lombardo E, van der Poll T, DelaRosa O, Dalemans W. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World Journal of Stem Cells. 2015;7(2):368.
  19. Körbling M, Estrov Z. Adult stem cells for tissue repair—a new therapeutic concept? New England Journal of Medicine. 2003;349(6):570-82.
  20. Rosenzweig A. Cardiac cell therapy—mixed results from mixed cells. Mass Medical Soc; 2006. p. 1274-7.
  21. Siegel G, Schäfer R, Dazzi F. The immunosuppressive properties of mesenchymal stem cells. Transplantation. 2009;87(9S):S45-S9.
  22. Yoo KH, Jang IK, Lee MW, Kim HE, Yang MS, Eom Y, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cellular immunology. 2009;259(2):150-6.
  23. Najar M, Raicevic G, Boufker HI, Kazan HF, De Bruyn C, Meuleman N, et al. Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources. Cellular immunology. 2010;264(2):171-9.
  24. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. The Journal of Immunology. 2009;183(12):7787-98.
  25. Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood. 2007;109(1):228-34.
  26. Yan L, Jiang B, Niu Y, Wang H, Li E, Yan Y, et al. Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. Cell death discovery. 2018;4(1):1-14.
  27. Najar M, Raicevic G, Boufker HI, Fayyad-Kazan H, De Bruyn C, Meuleman N, et al. Adipose-tissue-derived and Wharton's jelly–derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor. Tissue Engineering Part A. 2010;16(11):3537-46.
  28. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem cells. 2006;24(4):1030-41.
  29. Atoui R, Chiu RC. Concise review: immunomodulatory properties of mesenchymal stem cells in cellular transplantation: update, controversies, and unknowns. Stem cells translational medicine. 2012;1(3):200-5.
  30. Nahumi A, Pirdel L, Asadi A, Abdolmaleki A. Evaluation of NLR Family CARD Domain Containing 3 and NLR Family CARD Domain Containing 5 Gene Expression in Interferon Gamma–Treated Mesenchymal Stem Cells from Wharton’s Jelly of Human Umbilical Cord. Gene, Cell and Tissue. 2021(In Press).
  31. English K, Wood KJ. Mesenchymal stromal cells in transplantation rejection and tolerance. Cold Spring Harbor perspectives in medicine. 2013;3(5):a015560.
  32. Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self‐renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. Journal of cellular biochemistry. 1997;64(2):278-94.
  33. Koç ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. Journal of clinical oncology. 2000;18(2):307-.
  34. Bocelli-Tyndall C, Bracci L, Schaeren S, Feder-Mengus C, Barbero A, Tyndall A, et al. Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by interleukins 2, 7 and 15. Annals of the rheumatic diseases. 2009;68(8):1352-9.
  35. Schurgers E, Kelchtermans H, Mitera T, Geboes L, Matthys P. Discrepancy between the in vitro and in vivoeffects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis research & therapy. 2010;12(1):1-11.
  36. Nahumi A, Panahi Y, Asadi A, Abdolmaleki A. Tracheal Anatomy and Factors Contributing to Tissue Engineering. Gene, Cell and Tissue. 2022(In Press).
  37. Fernandes TL, Gomoll AH, Lattermann C, Hernandez AJ, Bueno DF, Amano MT. Macrophage: a potential target on cartilage regeneration. Frontiers in immunology. 2020;11:111.
  38. Ding J, Chen B, Lv T, Liu X, Fu X, Wang Q, et al. Bone marrow mesenchymal stem cell-based engineered cartilage ameliorates polyglycolic acid/polylactic acid scaffold-induced inflammation through M2 polarization of macrophages in a pig model. Stem cells translational medicine. 2016;5(8):1079-89.
  39. Manferdini C, Paolella F, Gabusi E, Silvestri Y, Gambari L, Cattini L, et al. From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells. Arthritis research & therapy. 2016;18(1):1-13.
  40. O’Brien K, Tailor P, Leonard C, DiFrancesco LM, Hart DA, Matyas JR, et al. Enumeration and localization of mesenchymal progenitor cells and macrophages in synovium from normal individuals and patients with pre-osteoarthritis or clinically diagnosed osteoarthritis. International journal of molecular sciences. 2017;18(4):774.
  41. Haltmayer E, Ribitsch I, Gabner S, Rosser J, Gueltekin S, Peham J, et al. Co-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis. PLoS One. 2019;14(4):e0214709.
  42. Lepage SI, Robson N, Gilmore H, Davis O, Hooper A, St. John S, et al. Beyond cartilage repair: the role of the osteochondral unit in joint health and disease. Tissue Engineering Part B: Reviews. 2019;25(2):114-25.
  43. Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nature reviews immunology. 2012;12(6):443-58.
  44. Resnick IB, Barkats C, Shapira MY, Stepensky P, Bloom AI, Shimoni A, et al. Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC). American journal of blood research. 2013;3(3):225.
  45. Zhu W, Xu W, Jiang R, Qian H, Chen M, Hu J, et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Experimental and molecular pathology. 2006;80(3):267-74.
  46. Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, et al. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia. 2008;22(3):593-9.
  47. Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem cells. 2007;25(2):371-9.
  48. Nahumi A, Peymani M, Asadi A, Abdolmaleki A, Panahi Y. Decellularized tracheal scaffold as a promising 3D scaffold for tissue engineering applications. Tissue and Cell. 2023:102258.
  49. Nahumi A, Peymani M, Asadi A, Abdolmaleki A, Panahi Y, Shahmohammadi MA. Computational Study on the Binding of Tracheal Scaffold Extracellular Matrix Fibronectin to the Integrin of Adipose Tissue Stem Cells. Journal of Ardabil University of Medical Sciences. 2023;23(4):418-35.
  50. Claes L, Recknagel S, Ignatius A. Fracture healing under healthy and inflammatory conditions. Nature Reviews Rheumatology. 2012;8(3):133-43.
  51. Najafi R, Asadi A, Zahri S, Abdolmaleki A. Preparing Sheep Bladder Scaffold and Examining the Differentiation of Mesenchymal Stem Cell Into Myocytes on Scaffolds. Gene, Cell and Tissue. 2021;8(3).
  52. Koh CJ, Atala A. Tissue engineering, stem cells, and cloning: opportunities for regenerative medicine. Journal of the American Society of Nephrology. 2004;15(5):1113-25.
  53. Forgacs G, Sun W. Biofabrication: micro-and nano-fabrication, printing, patterning and assemblies: William Andrew; 2013.
  54. Koh RH, Jin Y, Kim J, Hwang NS. Inflammation-modulating hydrogels for osteoarthritis cartilage tissue engineering. Cells. 2020;9(2):419.
  55. He J, Chen G, Liu M, Xu Z, Chen H, Yang L, et al. Scaffold strategies for modulating immune microenvironment during bone regeneration. Materials Science and Engineering: C. 2020;108:110411.
  56. Ueno M, Lo CW, Barati D, Conrad B, Lin T, Kohno Y, et al. Interleukin‐4 overexpressing mesenchymal stem cells within gelatin‐based microribbon hydrogels enhance bone healing in a murine long bone critical‐size defect model. Journal of biomedical materials research Part A. 2020;108(11):2240-50.
  57. Liu Y, Yang R, Shi S. Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory T cells. Tissue Engineering Part A. 2015;21(3-4):498-509.
  58. Fu J, Wang Y, Jiang Y, Du J, Xu J, Liu Y. Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis. Stem cell research & therapy. 2021;12(1):1-15.
آمار
تعداد مشاهده مقاله: 244
تعداد دریافت فایل اصل مقاله: 264


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب