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Evaluation of the Anti-inflammatory and Immunomodulatory Properties of Jatropha multifida stem sap | ||
| Journal of Medicinal plants and By-Products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 تیر 1403 اصل مقاله (833.23 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2024.363925.1622 | ||
| نویسندگان | ||
| Lauris Fah1، 2؛ Jean Robert Klotoé* 1، 3؛ Eric Agbodjento1؛ Victorien Tamègnon Dougnon1؛ Alice Kitchey1؛ Kévin Sintondji1؛ Esther Déguénon1؛ Jean Marc Atègbo4 | ||
| 1Research Unit in Applied Microbiology and Pharmacology of natural substances, Polytechnic school of Abomey-Calavi, University of Abomey-Calavi | ||
| 2National Medico-Sanitary Institute (INMeS), University of Abomey-Calavi | ||
| 3Multidisciplinary Research Laboratory for Technical Education (LARPET) of the National Higher School for Technical Education (ENSET) of Lokossa; National University of Science, Technology, Engineering and Mathematics (UNSTIM), Abomey, Benin | ||
| 4Faculty of Science and Technology, University of Abomey-Calavi | ||
| چکیده | ||
| Inflammatory diseases remain a significant public health issue, posing challenges in their management due to the adverse effects associated with conventional anti-inflammatory drugs. Exploring medicinal plants as a viable avenue for researching novel anti-inflammatory drugs offers a promising alternative. Jatropha multifida is a well-known traditional plant of the Euphorbiaceae family with undisputed medicinal properties, both haemostatic and antimicrobial. Very little data exists on its anti-inflammatory properties. This study aimed to assess the anti-inflammatory and immunomodulatory properties of Jatropha multifida stem sap The anti-inflammatory activity of the stem sap was evaluated in vitro by the anti-hemolytic activity assessment method, in vivo by the paw edema test in rats. The immunomodulatory potential was determined using a chemical mediator of inflammation, TNFα. Its antioxidant activity by the DPPH method was evaluated. The results of this study revealed that Jatropha multifida sap with an LC50 of 0.604 mg/mL, is non-toxic and showed a 66.21% higher anti-hemolytic effect than Diclofenac (25.94 %) and Ibuprofen (40 %). It also has a high DPPH inhibitory power (86.61 %) at 0.5 mg/mL similar to that of vitamin C. Sap at the concentration of 800 mg/Kg has overall the same effects on paw inflammation as Diclofenac and results in a greater decrease in TNFα (286.15) at values similar to those of normal control rats. The therapeutic use of this sap in a traditional setting is therefore once again justified due to its proven anti-inflammatory and immunomodulatory properties. | ||
| کلیدواژه‌ها | ||
| Jatropha multifida؛ Anti-inflammatory؛ Rat؛ TNFα | ||
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