اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,051
تعداد مقالات34,085
تعداد مشاهده مقاله46,577,934
تعداد دریافت فایل اصل مقاله77,619,851
esmaeili, hossein, Joghataei, Seyed Mehdi, Lotfalizade, Peyman, Khiabani, Fatemeh. (1403). Malignant Edema in Some Sheep Flocks of Iran. سامانه مدیریت نشریات علمی, 80(1), 153-160. doi: 10.32592/ARI.2025.80.1.153
hossein esmaeili; Seyed Mehdi Joghataei; Peyman Lotfalizade; Fatemeh Khiabani. "Malignant Edema in Some Sheep Flocks of Iran". سامانه مدیریت نشریات علمی, 80, 1, 1403, 153-160. doi: 10.32592/ARI.2025.80.1.153
esmaeili, hossein, Joghataei, Seyed Mehdi, Lotfalizade, Peyman, Khiabani, Fatemeh. (1403). 'Malignant Edema in Some Sheep Flocks of Iran', سامانه مدیریت نشریات علمی, 80(1), pp. 153-160. doi: 10.32592/ARI.2025.80.1.153
esmaeili, hossein, Joghataei, Seyed Mehdi, Lotfalizade, Peyman, Khiabani, Fatemeh. Malignant Edema in Some Sheep Flocks of Iran. سامانه مدیریت نشریات علمی, 1403; 80(1): 153-160. doi: 10.32592/ARI.2025.80.1.153

Malignant Edema in Some Sheep Flocks of Iran

Archives of Razi Institute
مقاله 18، دوره 80، شماره 1، فروردین و اردیبهشت 2025، صفحه 153-160    اصل مقاله (564.51 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.1.153
نویسندگان
hossein esmaeili* 1؛ Seyed Mehdi Joghataei2؛ Peyman Lotfalizade2؛ Fatemeh Khiabani2
1of Microbiology, Faculty of Veterinary Medicine, University of Tehran
2Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
چکیده
Malignant edema is a severe and swiftly fatal disease affecting domestic and wild livestock. The disease manifests following the introduction of Clostridium spp. into wounds or skin damage. Clostridium septicum is commonly linked with malignant edema. This disease, characterized by edema, doughy swelling, and skin necrosis, is underreported in Iran, leading to a lack of awareness among clinicians. Given its underreporting, addressing this issue is essential, prompting current research efforts to understand better its prognosis, bacteriological and molecular diagnosis, clinical signs, and treatment. Upon detecting suspicious signs of malignant edema in three separate flocks with imported breeds, investigations ensued, including regular clinical exams and sample collection from subcutaneous tissue. The impacted livestock consists of five Île-de-France sheep and two Romane rams, with one Île-de-France ram succumbing to the disease. The bacteriological procedure, including Gram staining and isolation of the causative agent, was meticulously carried out using the standard method. The PCR assay was conducted to validate the existence of C. septicum and reject the presence of Clostridium chauvoei by employing specific primers. The diagnosis of malignant edema in the affected sheep was confirmed through clinical, macroscopic, and bacteriological examinations, all of which corroborated the presence of C. septicum. The PCR assay demonstrated the presence of the C. septicum, verifying the bacteriological procedure. Initial signs of the infection included depression, weakness, high fever, and colic, followed by regional pain, crepitation, swelling characterized by a doughy consistency, edema, pain, and necrosis. The study highlights the potential for preventing malignant edema-related fatalities through early diagnosis and antibiotic intervention (Penicillin and Streptomycin). However, it notes a persistent challenge: the inability to repair necrotic tissue at the lesion site. Malignant edema, not being a prominently warned disease and with vaccinations available against its causative agent, has received comparatively less focus from clinicians and researchers in Iran.
کلیدواژه‌ها
Malignant edema؛ Clostridium septicum؛ Sheep؛ Crepitation؛ Gas gangrene
مراجع
  1. Smith MC, Sherman DM. Goat medicine. Third edition ed: John Wiley & Sons, Inc.; 2023.
  2. David G. Pugh NNB. Sheep and goat medicine. 2 ed: Elsevier/Saunders; 2012. 621 p.
  3. Gazioglu A, Karagülle B, Yüksel H, Nuri Açık M, Keçeci H, Dörtbudak MB, Çetinkaya B. Sudden death due to gas gangrene caused by Clostridium septicum in goats. BMC Vet Res. 2018;14(1):406.
  4. Ferrer LM, Esmaeili H, Lacasta D, Ramos JJ. Atlas of Sheep and Goat Diseases: Dr.Herriot - Spain; 2024.
  5. Constable PD, Hinchcliff KW, Done SH, Grünberg W. Veterinary medicine: a textbook of the diseases of cattle, horses, sheep, pigs and goats: Elsevier Health Sciences; 2016.
  6. Alves MLF, Ferreira MRA, Donassolo RA, Rodrigues RR, Conceição FR. Clostridium septicum: a review in the light of alpha-toxin and development of vaccines. Vaccine. 2021;39(35):4949-56.
  7. Sepehrifar HR, Pilehchian Langroudi R, Ataei S, Haddadi A. Evaluation and Comparison of Clostridium Epsilon-Alpha Fusion Gene Expression Using Different Commercial Expression Vector. Archives of Razi Institute. 2021;76(1):7-16.
  8. Morris w, Uzal f, Fattorini f, Terzolo h. Malignant oedema associated with blood-sampling in sheep. Australian Veterinary Journal. 2002;80(5):280-1.
  9. Costa JN, Oliveira, M. M. D. D., Lobato, F. C. F., Souza Júnior, M. F. D., Martins, N. E., Carvalho, A. V. A. D., ... & Uzal, F. A. Outbreak of malignant oedema in sheep caused by Clostridium sordellli, predisposed by routine vaccination. Veterinary Record. 2007;160:594-5.
  10. Esmaeili H, Ghorani M, Arani EB, Shakeri AP. Detection of contagious ovine ecthyma (orf) and risk factors for infection in small ruminants in Iran. Comparative Immunology, Microbiology and Infectious Diseases. 2021;79:101714.
  11. Markey B, Leonard F, Archambault M, Cullinane A, Maguire D. Clinical Veterinary Microbiology E-Book: Elsevier Health Sciences; 2013.
  12. Quinn PJ, Markey BK, Leonard FC, Hartigan P, Fanning S, Fitzpatrick ES. Veterinary Microbiology and Microbial Disease: Wiley; 2011.
  13. Khiav LA, Paradise A. Identification of Clostridium septicum in Clinical Cases Suspected to Braxy and Malignant Edema by Traditional and Molecular Method and Evaluation of Toxigenic Isolates for Vaccine Production. Microbiology Research Journal International. 2020;30(12):23-30.
  14. Junior CAO, Silva RO, Lobato FC, Navarro MA, Uzal FA. Gas gangrene in mammals: a review. Journal of veterinary diagnostic investigation. 2020;32(2):175-83.
  15. Uzal FA, Songer JG, Prescott JF, Popoff MR. Clostridial Diseases of Animals: Wiley; 2016.
  16. Costa J, Oliveira M, Lobato F, MF SJ, Martins N, Carvalho A, et al. Outbreak of malignant oedema in sheep caused by Clostridium sordellii, predisposed by routine vaccination. The Veterinary Record. 2007;160(17):594-5.
  17. Gohari IM, Prescott JF. Clostridium. Vet Microbiol. 2022:309-34.
  18. Fathi Najafi M, Hemmaty M, Navidmehr J, Afsharian M, Farhoodi M, Zibaee S. Improvement in the Growth and α-toxin Production of Clostridium septicum by Magnesium Sulfate. Archives of Razi Institute. 2020;75(2):219-25.
  19. Kennedy CL, Krejany EO, Young LF, O'Connor JR, Awad MM, Boyd RL, et al. The α‐toxin of Clostridium septicum is essential for virulence. Molecular microbiology. 2005;57(5):1357-66.
  20. Kennedy CL, Lyras D, Cordner LM, Melton-Witt J, Emmins JJ, Tweten RK, Rood JI. Pore-forming activity of alpha-toxin is essential for Clostridium septicum-mediated myonecrosis. Infection and Immunity. 2009;77(3):943-51.
  21. Kirchweger P, Wundsam H, Bosse F, Fritz A, Kratzer T, Kalteis M, et al. Systematic literature review and meta-analysis of Clostridium septicum aortitis. Journal of Vascular Surgery. 2022;76(2):595-604. e1.
  22. Pedersen S. Diversification of clostridial conditions in cattle and sheep. Veterinary Times. 2016;46(23):10, 2.
  23. Cihan H, Yalcin E, Mecitoglu Z, Senturk S. Outbreak of malignant oedema in sheep following vaccination with a multivalent clostridial bacterin-toxoid. Tierärztliche Praxis Ausgabe G: Großtiere/Nutztiere. 2010;38(03):165-7.
  24. Morris W, Uzal F, Paramidani M. Malignant oedema associated with navel infection in a Merino lamb. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 2002;54(4):448-9.
  25. Pedersen S. Diversification of clostridial conditions in cattle and sheep. Vet Times. 2016;6:1-9.
  26. Hossein E, Seyed Mehdi J. Meningoencephalitic Listeriosis in Iranian Sheep and Goats. Journal of Medical Bacteriology. 2024;12(2).
  27. Sasaki Y, Kojima A, Aoki H, Ogikubo Y, Takikawa N, Tamura Y. Phylogenetic analysis and PCR detection of Clostridium chauvoei, Clostridium haemolyticum, Clostridium novyi types A and B, and Clostridium septicum based on the flagellin gene. Vet Microbiol. 2002;86(3):257-67.
آمار
تعداد مشاهده مقاله: 322
تعداد دریافت فایل اصل مقاله: 365


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب