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Ogedengbe, Oluwatosin, Imoyin-Omene, Emuobonuvie, Adekeye, Adeshina, Ajiboye, Basiru, Adeeyo, Olusola. (1403). Ameliorative Potential of Resveratrol on Kidney Toxicities Following Adjuvant Treatment with Antiretroviral Drugs in Male Wistar Rats. سامانه مدیریت نشریات علمی, 79(3), 565-574. doi: 10.32592/ARI.2024.79.3.565
Oluwatosin Olalekan Ogedengbe; Emuobonuvie Imoyin-Omene; Adeshina Oloruntoba Adekeye; Basiru Olaitan Ajiboye; Olusola Atilade Adeeyo. "Ameliorative Potential of Resveratrol on Kidney Toxicities Following Adjuvant Treatment with Antiretroviral Drugs in Male Wistar Rats". سامانه مدیریت نشریات علمی, 79, 3, 1403, 565-574. doi: 10.32592/ARI.2024.79.3.565
Ogedengbe, Oluwatosin, Imoyin-Omene, Emuobonuvie, Adekeye, Adeshina, Ajiboye, Basiru, Adeeyo, Olusola. (1403). 'Ameliorative Potential of Resveratrol on Kidney Toxicities Following Adjuvant Treatment with Antiretroviral Drugs in Male Wistar Rats', سامانه مدیریت نشریات علمی, 79(3), pp. 565-574. doi: 10.32592/ARI.2024.79.3.565
Ogedengbe, Oluwatosin, Imoyin-Omene, Emuobonuvie, Adekeye, Adeshina, Ajiboye, Basiru, Adeeyo, Olusola. Ameliorative Potential of Resveratrol on Kidney Toxicities Following Adjuvant Treatment with Antiretroviral Drugs in Male Wistar Rats. سامانه مدیریت نشریات علمی, 1403; 79(3): 565-574. doi: 10.32592/ARI.2024.79.3.565

Ameliorative Potential of Resveratrol on Kidney Toxicities Following Adjuvant Treatment with Antiretroviral Drugs in Male Wistar Rats

Archives of Razi Institute
مقاله 16، دوره 79، شماره 3، مرداد و شهریور 2024، صفحه 565-574    اصل مقاله (411.2 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.3.565
نویسندگان
Oluwatosin Olalekan Ogedengbe* 1؛ Emuobonuvie Imoyin-Omene2؛ Adeshina Oloruntoba Adekeye2؛ Basiru Olaitan Ajiboye3؛ Olusola Atilade Adeeyo4
1Department of Anatomy, Faculty of Basic Medical Sciences, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, Nigeria (2) Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria
2Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria
3Department of Biochemistry, Faculty of Science, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, Nigeria
4Department of Anatomy, Faculty of Basic Medical Sciences, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, Nigeria
چکیده
Prolonged utilization of antiretroviral agents has been explicitly associated with nephrotoxicity, suggesting deterioration in renal function among patients receiving Highly Active Antiretroviral Therapy (HAART). The current investigation aimed to explore the therapeutic efficacy of resveratrol (RV) for the management of renal impairment resulting from antiretroviral drug toxins. Twenty-four adult male Wistar rats weighing 70–90 g were divided into four groups and subjected to the following treatments: Control A (distilled water), B (HAART), C (RV-2.5 mg/kg), and D (RV- 2.5 mg/kg) + HAART. The assessment included renal histological examination; renal functional indicators such as serum creatinine and blood urea nitrogen; serum electrolyte levels including sodium, chloride, potassium, and bicarbonate; and oxidative stress biomarkers such as malondialdehyde, catalase, glutathione, and superoxide dismutase. The detrimental effects of HAART include adverse histological modifications, such as tubular atrophy, vacuolization, tubular granular degeneration, and abnormalities in glomerular capillaries. Compared to the other treatment cohorts, there were significant increases in the levels of serum creatinine, blood urea nitrogen (BUN), sodium, chloride, and malondialdehyde (MDA), while antioxidant enzyme activities such as catalase (CAT) and superoxide dismutase (SOD) and glutathione (GSH) levels were notably decreased. The renal structure remained predominantly unchanged following RV administration, exhibiting a degree of recovery in histological abnormalities. Visible improvements, including decreased inflammation, reduced necrosis, diminished vacuolization, and enhanced tubule and glomerular configuration, were also noted. Additionally, RV notably increased antioxidant enzyme levels (SOD, CAT, and GSH) and reduced BUN, serum creatinine, and MDA levels. RV helped mitigate structural abnormalities and kidney dysfunction induced by HAART, while improving kidney morphology. However, further investigation into these mechanisms is necessary.
کلیدواژه‌ها
HAART؛ resveratrol؛ nephrotoxicity؛ antioxidant؛ Wistar rats
سایر فایل های مرتبط با مقاله
مراجع
  1. Kabiibi F, Tamukong R, Muyindike W, Yadesa TM. Virological Non-Suppression, Non-Adherence and the Associated Factors Among People Living with HIV on Dolutegravir-Based Regimens: A Retrospective Cohort Study. HIV/AIDS-Research and Palliative Care. 2024:95-107.
  2. Wang Y, Wu G, Wen Z, Lei H, Lin F. Highly active antiretroviral therapy-related effects on morphological connectivity in HIV. AIDS. 2024;38(2):207-15.
  3. Aye SL, Trivedi Y, Bolgarina Z, Desai HN, Senaratne M, Swami SS, et al. The Prognosis of Progressive Multifocal Leukoencephalopathy in HIV/AIDS Patients Undergoing Highly Active Antiretroviral Treatment: A Systematic Review. Cureus. 2023;15(9).
  4. Desta AA, Kidane KM, Bahta YW, Ajemu KF, Woldegebriel AG, Berhe AA, et al. Determinants of immunological recovery following HAART among severely immunosuppressed patients at enrolment to care in Northern Ethiopia: a retrospective study. BMJ open. 2020;10(8):e038741.
  5. Narváez M, Lins-Kusterer L, Valdelamar-Jiménez J, Brites C. Quality of life and antiretroviral therapy adherence: A cross-sectional study in Colombia. AIDS Research and Human Retroviruses. 2022;38(8):660-9.
  6. Wearne N, Davidson B, Blockman M, Swart A, Jones ES. HIV, drugs and the kidney. Drugs in context. 2020;9.
  7. Heron JE, Bagnis CI, Gracey DM. Contemporary issues and new challenges in chronic kidney disease amongst people living with HIV. AIDS research and therapy. 2020;17(1):1-13.
  8. Manaye GA, Abateneh DD, Niguse W. Chronic kidney disease and associated factors among HIV/AIDS patients on HAART in Ethiopia. HIV/AIDS-Research and Palliative Care. 2020:591-9.
  9. Perazella MA, Rosner MH. Drug-induced acute kidney injury. Clinical Journal of the American Society of Nephrology. 2022;17(8):1220-33.
  10. Penner J, Ombajo LA, Otieno D, Nkuranga J, Mburu M, Wahome S, et al. High rates of kidney impairment among older people (≥ 60 years) living with HIV on first-line antiretroviral therapy at screening for a clinical trial in Kenya. Plos one. 2023;18(6):e0285787.
  11. Cullaro G, Kanduri SR, Velez JCQ. Acute kidney injury in patients with liver disease. Clinical Journal of the American Society of Nephrology. 2022;17(11):1674-84.
  12. Pry JM, Vinikoor MJ, Bolton Moore C, Roy M, Mody A, Sikazwe I, et al. Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia. PLOS Global Public Health. 2022;2(4):e0000124.
  13. Ma X, Zhang H, Wang S, Deng R, Luo D, Luo M, et al. Recent Advances in the Discovery and Development of Anti-HIV Natural Products. The American Journal of Chinese Medicine. 2022;50(05):1173-96.
  14. Jiménez-Osorio AS, Jaen-Vega S, Fernández-Martínez E, Ortíz-Rodríguez MA, Martínez-Salazar MF, Jiménez-Sánchez RC, et al. Antiretroviral therapy-induced dysregulation of gene expression and lipid metabolism in HIV+ patients: beneficial role of antioxidant phytochemicals. International Journal of Molecular Sciences. 2022;23(10):5592.
  15. Enyang D, Sonibare MA, Tchamgoue AD, Tchokouaha LR, Yadang FS, Nfor GN, et al. Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats. Journal of Toxicology. 2024;2024.
  16. Brisdelli F, D'Andrea G, Bozzi A. Resveratrol: a natural polyphenol with multiple chemopreventive properties. Current drug metabolism. 2009;10(6):530-46.
  17. Ugoeze KC, Bakshi IS, Chinko BC, Oluigbo KE, Okoronkwo NA, Alalor CA. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomedical Sciences. 2023;9(1):pp. 18-29.
  18. Bala S, Misra A, Kaur U, Shubhra S. Resveratrol: A Novel Drug for the Management of Neurodegenerative Disorders. Traditional Medicine for Neuronal Health. 2023:230.
  19. Cao S, Fu X, Yang S, Tang S. The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies. Pharmaceutical Biology. 2022;60(1):2088-97.
  20. Tain Y-L, Chang C-I, Hou C-Y, Chang-Chien G-P, Lin S, Hsu C-N. Dietary Resveratrol Butyrate Monoester Supplement Improves Hypertension and Kidney Dysfunction in a Young Rat Chronic Kidney Disease Model. Nutrients. 2023;15(3):635.
  21. Chen Y, Ye X, Jin S, Huang W, Chen C, Chen X. Resveratrol protects against sepsis induced acute kidney injury in mice by inducing Klotho mediated apoptosis inhibition. Tropical Journal of Pharmaceutical Research. 2022;21(8):1615-23.
  22. Gimblet C, Kruse N, Geasland K, Mickelson J, Sun M, Rehman S, et al. Resveratrol supplementation improves endothelial function in chronic kidney disease. Physiology. 2023;38(S1):5786210.
  23. Zhou D-D, Luo M, Huang S-Y, Saimaiti A, Shang A, Gan R-Y, et al. Effects and mechanisms of resveratrol on aging and age-related diseases. Oxidative medicine and cellular longevity. 2021;2021:1-15.
  24. Weichbrod RH, Thompson GA, Norton JN. Management of animal care and use programs in research, education, and testing: CRC Press Boca Raton; 2018.
  25. Pawan KS, Raman MS, Satish CM, Gyanendra NS, Chhoten LJ. A rapid and sensitive RP-UPLC method for simultaneous determination of zidovudine, lamivudine and nevirapine in tablet dosage form. Journal of Pharmaceutical Research. 2010;9(2):56-9.
  26. Ogedengbe OO, Bature A, Fafure A, Kehinde S, Adekeye A, Akintayo C, et al. Evaluation of Testicular Function and Structural Changes of Wistar Rats Following Antiretroviral Exposure: Protective Role of Cyperus esculentus. Nigerian Journal of Physiological Sciences. 2023;38(2):201-9.
  27. Ogedengbe OO, Saliu H, Fafure AA, Akintayo CO, Adekeye AO, Ajiboye BO, et al. Hippocampus and Prefrontal Cortex Following the Use of Anti-Retroviral Therapy in Adult Wistar Rats: Therapeutic Role of Epigallocatechin Gallate. Nigerian Journal of Physiological Sciences. 2022;37(2):207-14.
  28. Offor U, Naidu EC, Ogedengbe OO, Jegede AI, Peter AI, Azu OO. Nephrotoxicity and highly active antiretroviral therapy: mitigating action of Momordica charantia. Toxicology reports. 2018;5:1153-60.
  29. Kiernan JA, Kmiec Z. Histological and Histochemical Methods: Theory and Practice. Scion Publishing, 2015, 571 pp. Folia histochemica et cytobiologica. 2016;54(1):58-9.
  30. Ochei JO, Kolhatkar AA. Medical laboratory science: theory and practice: Tata McGraw-Hill, New York; 2008.
  31. Isah R, Mohammed M, Muhammad A, Sahabi S, Umar Z, Mahmud R, et al. Effects of aqueous leaf extracts of Senna occidentalis on rat kidney. African Journal of Biomedical Research. 2018;21(2):225-30.
  32. Albro PW, Corbett JT, Schroeder JL. Application of the thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes. Journal of Biochemical and Biophysical Methods. 1986;13(3):185-94.
  33. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry. 1968;25:192-205.
  34. Berwal M, Ram C. Superoxide dismutase: A stable biochemical marker for abiotic stress tolerance in higher plants. Abiotic and biotic stress in plants. 2018:1-10.
  35. Aebi H. Catalase. Methods of enzymatic analysis: Elsevier; 1974. p. 673-84.
  36. Dauchy F-A, Lawson-Ayayi S, de La Faille R, Bonnet F, Rigothier C, Mehsen N, et al. Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy. Kidney international. 2011;80(3):302-9.
  37. Mekuria Y, Yilma D, Mekonnen Z, Kassa T, Gedefaw L. Renal function impairment and associated factors among HAART Naïve and experienced adult HIV positive individuals in Southwest Ethiopia: a comparative cross sectional study. PloS one. 2016;11(8):e0161180.
  38. Kwizera E, Ssekatawa K, Aja PM, Miruka CO, Wandera A, Mpumbya JR, et al. Methanol Crude Peel Extract of P. granatum Prevents Oxidative Damage in Kidneys of Rats Exposed to Highly Active Antiretroviral Therapy. Journal of Experimental Pharmacology. 2024:1-11.
  39. Avraham S, Korin B, Chung J-J, Oxburgh L, Shaw AS. The Mesangial cell—the glomerular stromal cell. Nature Reviews Nephrology. 2021;17(12):855-64.
  40. Sharifi-Rad J, Quispe C, Durazzo A, Lucarini M, Souto EB, Santini A, et al. Resveratrol’biotechnological applications: Enlightening its antimicrobial and antioxidant properties. Journal of Herbal Medicine. 2022;32:100550.
  41. Canedo‐Santos JC, Carrillo‐Garmendia A, Mora‐Martinez I, Gutierrez‐Garcia IK, Ramirez‐Romero MG, Regalado‐Gonzalez C, et al. Resveratrol shortens the chronological lifespan of Saccharomyces cerevisiae by a pro‐oxidant mechanism. Yeast. 2022;39(3):193-207.
  42. Chen Y, Zelnick LR, Wang K, Katz R, Hoofnagle AN, Becker JO, et al. Association of tubular solute clearances with the glomerular filtration rate and complications of chronic kidney disease: the Chronic Renal Insufficiency Cohort study. Nephrology Dialysis Transplantation. 2021;36(7):1271-81.
  43. Rahman WK, Rabea IS, Meizel MM. Protective effect of activated charcoal against progression of chronic kidney disease: A randomized clinical study. Journal of Medicine and Life. 2023;16(9):1310.
  44. Arif H. Complications of Chronic Kidney Disease: Electrolyte and Acid-Base Disorders. Approaches to Chronic Kidney Disease: A Guide for Primary Care Providers and Non-Nephrologists. 2022:211-33.
  45. Yusuf R, Aliyu I, Anaja P, Muktar H. Serum electrolytes, calcium, phosphate and uric acid in hiv/aids patients on HAART in a tertiary hospital in northern Nigeria
Nigerian Journal of Pharmaceutical Sciences 2010;9(1):95 –100

  1. Zandijk AJ, van Norel MR, Julius FE, Sepehrvand N, Pannu N, McAlister FA, et al. Chloride in heart failure: the neglected electrolyte. Heart Failure. 2021;9(12):904-15.
  2. Burnier Sr M. Nutritional management of sodium, chloride, and water in kidney disease and kidney failure. Nutritional Management of Renal Disease: Elsevier; 2022. p. 313-28.
  3. Yamane DP, Maghami S, Graham A, Vaziri K, Davison D. Association of hyperchloremia and acute kidney injury in patients with traumatic brain injury. Journal of Intensive Care Medicine. 2022;37(1):128-33.
  4. Sigmon J, May CC, Bryant A, Humanez J, Singh V. Assessment of acute kidney injury in neurologically injured patients receiving hypertonic sodium chloride: does chloride load matter? Annals of Pharmacotherapy. 2020;54(6):541-6.
  5. Rein JL, Coca SG. “I don’t get no respect”: the role of chloride in acute kidney injury. American Journal of Physiology-Renal Physiology. 2019;316(3):F587-F605.
  6. Liu F, Ma G, Tong C, Zhang S, Yang X, Xu C, et al. Elevated blood urea nitrogen-to-creatinine ratio increased the risk of Coronary Artery Disease in patients living with type 2 diabetes mellitus. BMC Endocrine Disorders. 2022;22(1):50.
  7. Meri MA, Al-Hakeem AH, Al-Abeadi RS, Mahdi DM. Study of the changes of some biochemical parameters of patients with renal failure. Bulletin of National Institute of Health Sciences. 2022;140(3):2925-33.
  8. Paczkowska-Walendowska M, Miklaszewski A, Michniak-Kohn B, Cielecka-Piontek J. The antioxidant potential of resveratrol from red vine leaves delivered in an electrospun nanofiber system. Antioxidants. 2023;12(9):1777.
  9. Apostolova N, Blas-Garcia A, V Esplugues J. Mitochondrial toxicity in HAART: an overview of in vitro evidence. Current pharmaceutical design. 2011;17(20):2130-44.
  10. Andrade-Sierra J, Pazarín-Villaseñor L, Yanowsky-Escatell FG, Díaz-de la Cruz EN, García-Sánchez A, Cardona-Muñoz EG, et al. The Influence of the Severity of Early Chronic Kidney Disease on Oxidative Stress in Patients with and without Type 2 Diabetes Mellitus. International Journal of Molecular Sciences. 2022;23(19):11196.
  11. Ranasinghe R, Mathai M, Zulli A. Cytoprotective remedies for ameliorating nephrotoxicity induced by renal oxidative stress. Life Sciences. 2023;318:121466.
  12. Demirci-Cekic S, Özkan G, Avan AN, Uzunboy S, Çapanoğlu E, Apak R. Biomarkers of oxidative stress and antioxidant defense. Journal of pharmaceutical and biomedical analysis. 2022;209:114477.
  13. Adıkwu E, Owota RO, Biradee I. Curcumin prevents tenofovir/lamivudine/efavirenzinduced nephrotoxicity in rats. Istanbul Journal of Pharmacy. 2021;51(2):221-7.
  14. Chen Y-F, Stampley JE, Irving BA, Dugas TR. Chronic nucleoside reverse transcriptase inhibitors disrupt mitochondrial homeostasis and promote premature endothelial senescence. Toxicological Sciences. 2019;172(2):445-56.
  15. Schank M, Zhao J, Moorman JP, Yao ZQ. The impact of HIV-and ART-induced mitochondrial dysfunction in cellular senescence and aging. Cells. 2021;10(1):174.
  16. Herman ES, Klotman PE. HIV-associated nephropathy: epidemiology, pathogenesis, and treatment. Seminars in nephrology. 2003;23(2):200-8.
  17. Daugas E, Rougier J-P, Hill G. HAART-related nephropathies in HIV-infected patients. Kidney international. 2005;67(2):393-403.
  18. Carmo de Carvalho e Martins Md, Martins, da Silva Santos Oliveira AS, da Silva LAA, Primo MGS, de Carvalho Lira VB. Biological indicators of oxidative stress [malondialdehyde, catalase, glutathione peroxidase, and superoxide dismutase] and their application in nutrition. Biomarkers in Nutrition: Springer; 2022. p. 1-25.
  19. Chukwuebuka NB, Elias DTM, Ijego AE, Peggy OE, Ejime A-C, Omeru O. Changes in antioxidant enzymes activities and lipid peroxidase level in tissues of stress-induced rats. Biomedical and Pharmacology Journal. 2021;14(2):583-96.
  20. Zhang Q, Zhang C, Ge J, Lv M-W, Talukder M, Guo K, et al. Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy. Food & function. 2020;11(2):1856-68.
  21. Lan T-y, Dun R-l, Yao D-s, Wu F, Qian Y-l, Zhou Y, et al. Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis. Frontiers in Nutrition. 2023;9:1064507.
  22. Thirumalaisamy R, Bhuvaneswari M, Haritha S, Jeevarathna S, Janani KS, Suresh K. Curcumin, naringenin and resveratrol from natural plant products hold promising solutions for modern world diseases–A recent review. South African Journal of Botany. 2022;151:567-80.
 

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