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Malik, Wardah, Mufaddal, Zahra, Afzal, Yumna, Yusuf, Farah, Akhtar, Soubia, Rizvi, Syed Haider. (1404). Synovial Sarcoma; A Rare Entity In Submandibular Gland. سامانه مدیریت نشریات علمی, 80(2), 635-638. doi: 10.32592/ARI.2025.80.1.635
Wardah Ramaisa Malik; Zahra Mufaddal; Yumna Afzal; Farah Hafiz Yusuf; Soubia Akhtar; Syed Haider Abbas Rizvi. "Synovial Sarcoma; A Rare Entity In Submandibular Gland". سامانه مدیریت نشریات علمی, 80, 2, 1404, 635-638. doi: 10.32592/ARI.2025.80.1.635
Malik, Wardah, Mufaddal, Zahra, Afzal, Yumna, Yusuf, Farah, Akhtar, Soubia, Rizvi, Syed Haider. (1404). 'Synovial Sarcoma; A Rare Entity In Submandibular Gland', سامانه مدیریت نشریات علمی, 80(2), pp. 635-638. doi: 10.32592/ARI.2025.80.1.635
Malik, Wardah, Mufaddal, Zahra, Afzal, Yumna, Yusuf, Farah, Akhtar, Soubia, Rizvi, Syed Haider. Synovial Sarcoma; A Rare Entity In Submandibular Gland. سامانه مدیریت نشریات علمی, 1404; 80(2): 635-638. doi: 10.32592/ARI.2025.80.1.635

Synovial Sarcoma; A Rare Entity In Submandibular Gland

Archives of Razi Institute
مقاله 30، دوره 80، شماره 2، خرداد و تیر 2025، صفحه 635-638    اصل مقاله (351.57 K)
نوع مقاله: Case Study
شناسه دیجیتال (DOI): 10.32592/ARI.2025.80.1.635
نویسندگان
Wardah Ramaisa Malik1؛ Zahra Mufaddal2؛ Yumna Afzal* 2؛ Farah Hafiz Yusuf2؛ Soubia Akhtar2؛ Syed Haider Abbas Rizvi2
1department of otolaryngology and head and neck surgery, DOW University of Health and Sciences
2department of otolaryngology and head and neck surgery, Dr Ziauddin University hospital, Karachi, Pakistan
چکیده
ABSTRACT:

INTRODUCTION: Salivary gland synovial sarcomas, constituting <1% of oral tumors, occurring mostly in young and adolescents age group, present diagnostic challenges. it clinically presents as a painless mass, often growing silently for months or even years. Grossly, synovial sarcoma presents as a tan or grey mass with multi-nodular or multi-cystic formations and is characterized by the presence of spindle cells and CKAE1/AE3, TLE-1, and CD99 positivity. Prognosis is influenced by patient demographics, tumor characteristics, and treatment modalities. Factors such as age over 35 at diagnosis, epithelioid type, and localization outside the head and neck region are associated with worse prognoses.

CASE SUMMARY: We present a 48-year-old male with a swelling in the left submandibular area with no other associated symptoms. An ultrasound of the lump showed a well-circumscribed, cystic cum solid mass, with internal vascularity. Fine needle aspiration cytology (FNAC) demonstrated nuclear pleomorphism and high mitotic activity. Excisional histopathology was done and diagnosis of unifocal synovial sarcoma was made, characterized by spindle cells, with a mitotic rate of 23 per 10 high-power fields, with positivity for CKAE1/AE3, TLE-1, and CD99 and negativity for S100 in tumor cells.

CONCLUSION: We here presents a case of synovial sarcoma in an adult patient, with an unlikely site of occurrence This report also contributes to limited literature regarding this rare malignancy, shedding light on their clinical and diagnostic characteristics, and emphasizing identification of specific immunohistochemical markers such as CKAE1/AE3, TLE-1, and CD99 add to the understanding of its molecular characteristics

KEY-WORDS: Synovial sarcomas, submandibular gland, spindle cells, immunohistochemical markers.
کلیدواژه‌ها
Synovial sarcomas؛ submandibular gland؛ spindle cells؛ immunohistochemical markers
مراجع
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  7. Nielsen TO. Synovial Sarcoma. In: Maloy S, Hughes K, eds. Brenner’s Encyclopedia of Genetics (Second Edition). Academic Press; 2013:619-622.
  8. Terry J, Saito T, Subramanian S, et al. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol. 2007;31(2):240-246.
  9. Rekhi B, Basak R, Desai SB, Jambhekar NA. Immunohistochemical validation of TLE1, a novel marker, for synovial sarcomas. Indian J Med Res. 2012;136(5):766-775.
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تعداد مشاهده مقاله: 212
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