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Naseri, Amirhossein, Matoofi, Ardeshir, Mansouri Ramezani, Morteza, Kalantari, Leila, Taherzadeh Amlashi, Tina, Roudaki, Shahrzad, Mohammadian, Mahsa, Omranzadeh, Alireza. (1403). Comprehensive analysis of Papillomavirus (PV) and its implications in cancer: Bridging the gap between human and veterinary medicine. سامانه مدیریت نشریات علمی, 79(6), 1145-1154. doi: 10.32592/ARI.2024.79.6.1145
Amirhossein Naseri; Ardeshir Matoofi; Morteza Mansouri Ramezani; Leila Kalantari; Tina Taherzadeh Amlashi; Shahrzad Roudaki; Mahsa Mohammadian; Alireza Omranzadeh. "Comprehensive analysis of Papillomavirus (PV) and its implications in cancer: Bridging the gap between human and veterinary medicine". سامانه مدیریت نشریات علمی, 79, 6, 1403, 1145-1154. doi: 10.32592/ARI.2024.79.6.1145
Naseri, Amirhossein, Matoofi, Ardeshir, Mansouri Ramezani, Morteza, Kalantari, Leila, Taherzadeh Amlashi, Tina, Roudaki, Shahrzad, Mohammadian, Mahsa, Omranzadeh, Alireza. (1403). 'Comprehensive analysis of Papillomavirus (PV) and its implications in cancer: Bridging the gap between human and veterinary medicine', سامانه مدیریت نشریات علمی, 79(6), pp. 1145-1154. doi: 10.32592/ARI.2024.79.6.1145
Naseri, Amirhossein, Matoofi, Ardeshir, Mansouri Ramezani, Morteza, Kalantari, Leila, Taherzadeh Amlashi, Tina, Roudaki, Shahrzad, Mohammadian, Mahsa, Omranzadeh, Alireza. Comprehensive analysis of Papillomavirus (PV) and its implications in cancer: Bridging the gap between human and veterinary medicine. سامانه مدیریت نشریات علمی, 1403; 79(6): 1145-1154. doi: 10.32592/ARI.2024.79.6.1145

Comprehensive analysis of Papillomavirus (PV) and its implications in cancer: Bridging the gap between human and veterinary medicine

Archives of Razi Institute
مقاله 4، دوره 79، شماره 6، بهمن و اسفند 2024، صفحه 1145-1154    اصل مقاله (364.72 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.6.1145
نویسندگان
Amirhossein Naseri1؛ Ardeshir Matoofi2؛ Morteza Mansouri Ramezani3؛ Leila Kalantari4؛ Tina Taherzadeh Amlashi5؛ Shahrzad Roudaki6؛ Mahsa Mohammadian1؛ Alireza Omranzadeh* 1
1Medical doctor, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Radiation Oncology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Medical doctor, Golestan University of Medical Science, Gorgan, Iran
4Medical doctor, Kashan University of Medical Science, Kashan, Iran
5Medical doctor, Guilan University of Medical Sciences, Guilan, Iran
6Pharmacist, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Abstract
Papillomavirus (PV) infections pose a significant risk of cancer development in both humans and domestic animals, underscoring the importance of understanding and addressing this viral threat. Recent research highlights the potential of immunotherapies, remarkably immune checkpoint blockers (ICBs), in amplifying the immune response against tumor-associated antigens (TAAs) and tumor-related neoantigens, thereby aiding in their neutralization by the immune system. Moreover, vaccines tailored to heighten the immune response against PV-infected cells have demonstrated encouraging outcomes by bolstering CD4+ and CD8+ T cell reactions, potentially impeding cancer progression. The oncoproteins E6 and E7, notably implicated in malignancy development, exert deleterious effects by disrupting tumor suppressor proteins and facilitating immune evasion and tumor proliferation, particularly in high-risk PV genotypes like HPV-16 and HPV-18. Despite hurdles such as vaccine hesitancy and concerns regarding vaccine toxicity, PV vaccines have revolutionized disease prevention strategies, offering a beacon of hope in the fight against PV-associated cancers. Advancements in precision medicine and immunotherapy hold promise in managing advanced PV-related cancers by pinpointing and exploiting specific molecular vulnerabilities while bolstering immune responses. This transformative approach can potentially treat established cancers and prevent their recurrence and progression. Consequently, immunotherapies, therapeutic vaccines, and precision medicine have garnered substantial attention in scientific discourse due to their capacity to enhance the quality of life and outcomes for individuals afflicted with PV-related cancers. By harnessing the immune system's power and leveraging cutting-edge therapeutic modalities, researchers and clinicians are poised to reshape the landscape of cancer treatment, offering renewed hope and optimism for those affected by PV-associated malignancies. Thus, integrating innovative strategies into clinical practice is pivotal in combating the formidable challenge PV-induced cancers pose. In conclusion, this review illuminates a path forward in combating PV infections and associated malignancies, potentially revolutionizing the landscape of cancer treatment. By leveraging immunotherapies, therapeutic vaccines, and precision medicine, researchers and clinicians are poised to make significant strides in preventing and treating PV-related cancers, ultimately improving patient outcomes and quality of life.
کلیدواژه‌ها
Papillomavirus؛ cancer immunotherapy؛ Virus؛ oncogenic mechanisms؛ therapeutic strategies
عنوان مقاله [English]
تحلیل جامعی از ویروس پاپیلوما ویروس و پیامدهای آن در سرطان: پل ارتباطی بین پزشکی انسانی و دامپزشکی
چکیده [English]
عفونت‌های پاپیلوماویروس (PV) برای انسان‌ها و حیوانات خانگی، از جمله سگ‌ها و گربه‌ها، خطراتی را به همراه دارند که شامل توسعه سرطان می‌شود. تحقیقات اخیر نشان می‌دهد که بلاک‌کننده‌های چک‌پوینت ایمنی (ICBs)، در بهره‌برداری از سیستم ایمنی بدن در برابر آنتیژن‌های مرتبط با تومور (TAAs) و نئو-آنتیژن‌ها دارند. به‌طور خاص، واکسن‌های پاپیلوماویروسی درمانی، به‌ویژه واکسن‌های چند اپی‌توپ، قدرتمندی در تقویت پاسخ‌های سلول‌های T CD4+ و CD8+ در برابر سلول‌های آلوده به PV دارند، که می‌تواند در کاهش پیشرفت سرطان مؤثر باشد.
این مرور جامع به رابطه پیچیده میان پاپیلوماویروس (PV) و سرطان می‌پردازد، به نحوی که نشان می‌دهد ژنوتیپ‌های PV با خطر بالا، مانند HPV-16 و HPV-18، به خصوص سرطان سرویکس را تقویت می‌کنند. مرکز این بحث پروتئین‌های ویروسی E6 و E7 است، که نقش حیاتی در سرطان‌زایی میانجی HPV را با تداخل با پروتئین‌های سرکوبگر تومور p53 و pRB دارند، در نتیجه ایجاد مهار از سیستم ایمنی و رشد توموری را تسهیل می‌کنند.
علاوه بر این، مرور به توسعه واکسن‌های پاپیلوماویروسی درمانی پرداخته و بر مبنای واکسن‌های چند اپی‌توپ به عنوان یک مسیر امیدوارکننده برای تقویت پاسخ‌های ایمنی در برابر سرطان‌های مرتبط با HPV تمرکز دارد. با وجود چالش‌ها در مقابله با واکسیناسیون، مرور بر اثر متحول‌کننده واکسن‌های پاپیلوماویروسی با اثربخشی بالا در پیشگیری از بیماری‌های مرتبط تأکید می‌کند.
علاوه بر این، مطالعه پیشرفت‌هایی را در روش‌های درمانی مانند پزشکی دقیق و ایمونوتراپی مورد بررسی قرار می‌دهد، امیدواری برای مدیریت سرطان‌های مرتبط با HPV را ارائه می‌دهد. این نوآوری‌ها شامل درمان‌های هدفمندی است که از آسیب‌پذیری‌های مولکولی خاص در سلول‌های آلوده به HPV بهره می‌برند، و همچنین روش‌های ایمنی‌شناختی که پاسخ ایمنی بدن را در برابر سلول‌های بدخیم تقویت می‌کنند.
به طور خلاصه، این مرور مسیری روشن را در مقابله با عفونت‌های HPV و سرطان‌های مرتبط با آن نشان می‌دهد، که ممکن است چشم‌انداز درمان سرطان را طبیعتاً تغییر دهد. با بهره‌گیری از ایمونوتراپی، واکسن‌های درمانی و پزشکی دقیق، پژوهشگران و پزشکان قادر به گام‌های مهمی در جلوگیری و درمان سرطان‌های مرتبط با HPV هستند، که در نهایت بهبود نتایج بیمار و کیفیت زندگی را به ارمغان می‌آورند.
کلیدواژه‌ها [English]
پاپیلوما ویروس, ایمونوتراپی سرطان, ویروس, مکانیسم ایجاد سرطان, روش های درمان سرطان
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آمار
تعداد مشاهده مقاله: 320
تعداد دریافت فایل اصل مقاله: 277


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