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Emeka, Nnenna, Ghasi, Samuel, Sampson, Emeka, Erejuwa, Omotayo. (1403). Effect of honey on postprandial hyperglycemia in alloxan-induced diabetic rats. سامانه مدیریت نشریات علمی, 79(5), 943-948. doi: 10.32592/ARI.2024.79.5.943
Nnenna N Emeka; Samuel I Ghasi; Emeka Sampson; Omotayo O Erejuwa. "Effect of honey on postprandial hyperglycemia in alloxan-induced diabetic rats". سامانه مدیریت نشریات علمی, 79, 5, 1403, 943-948. doi: 10.32592/ARI.2024.79.5.943
Emeka, Nnenna, Ghasi, Samuel, Sampson, Emeka, Erejuwa, Omotayo. (1403). 'Effect of honey on postprandial hyperglycemia in alloxan-induced diabetic rats', سامانه مدیریت نشریات علمی, 79(5), pp. 943-948. doi: 10.32592/ARI.2024.79.5.943
Emeka, Nnenna, Ghasi, Samuel, Sampson, Emeka, Erejuwa, Omotayo. Effect of honey on postprandial hyperglycemia in alloxan-induced diabetic rats. سامانه مدیریت نشریات علمی, 1403; 79(5): 943-948. doi: 10.32592/ARI.2024.79.5.943

Effect of honey on postprandial hyperglycemia in alloxan-induced diabetic rats

Archives of Razi Institute
مقاله 8، دوره 79، شماره 5، آذر و دی 2024، صفحه 943-948    اصل مقاله (312.35 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.5.943
نویسندگان
Nnenna N Emeka1؛ Samuel I Ghasi2؛ Emeka Sampson3؛ Omotayo O Erejuwa* 4
1Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
2Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
3Ebonyi State Ministry of Health, Abakaliki, Ebonyi State, Nigeria
4Metabolism and Cardiovascular Research Group, Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria
چکیده
The role of postprandial hyperglycemia (PPH) is implicated in the etiology of diabetes mellitus and its complications. This study investigated the effect of honey on high glucose-induced PPH in alloxan-induced diabetic rats. Diabetes mellitus was induced by administering alloxan [150 mg/kg body weight (BW)] to overnight fasted rats. The diabetic rats were administered drinking water (1 ml/kg BW) or honey (1, 2 or 3 g/kg BW) via oral gavage. Each group comprised 6 rats. Before administration of drinking water or honey, baseline fasting blood glucose (BG) was measured as BG0. BG levels (BG60, BG120 and BG180) were then measured at 60, 120 and 180 minutes, respectively. Estimation of BG parameters [area under the curve (AUC), peak BG (PBG), percentage (%) variation in BG and % change in BG] was performed. The AUC and PBG did not differ in all the diabetic groups (irrespective of administered agents) compared with diabetic control group. Compared with BG0, the BG60 significantly (p < 0.05) increased in diabetic rats that received drinking water or honey (2 or 3 g/kg BW) but not in diabetic rats that received 1 g/kg BW of honey. The diabetic rats that received 1 g/kg BW of honey exhibited significantly (p < 0.05) lower % change in BG compared with the diabetic control rats. The study showed that administration of honey (irrespective of doses) did not deteriorate high glucose-induced PPH in diabetic rats. The study also indicated that 1 g/kg BW of honey was the most effective dose in suppressing PPH.
کلیدواژه‌ها
Diabetes mellitus؛ blood glucose؛ postprandial hyperglycemia؛ honey؛ alloxan
مراجع
  1. ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. on behalf of the American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46:S19-40.
  2. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet (London, England). 2023;402(10397):203-34.
  3. Pinés Corrales PJ, Bellido Castañeda V, Ampudia FJ. Update on postprandial hyperglycaemia: the pathophysiology, prevalence, consequences and implications of treating diabetes. Rev Clin Esp (Barc). 2020;220:57-68.
  4. Aryangat AV, Gerich JE. Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk. Vasc Health Risk Manag. 2010;24:145-55.
  5. Jokura H, Watanabe I, Umeda M, Hase T, Shimotoyodome A. Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults. Nutrition Res. 2015;10:873-81.
  6. Erejuwa OO, Sulaiman SA, AbdulWahab MS. Honey: a novel antioxidant. Molecules, 2012;17:4400-23.
  7. Shahsavari M, Norouzi P, Kalalianmoghaddam H, Teimouri M. Effects of Kudzu Root on Oxidative Stress and Inflammation in Streptozotocin-induced Diabetic Rats. Iran J Vet Med. 2023;17:401-8.
  8. Cheraghi J, Kridhchi P, Nasri S, Zargooshi M. Effects of Parsley (Petroselinum Crispum) Hydroalcoholic Extract on Spermatogenesis and Pituitary- Gonadal Axis in Streptozotocin-Induced Diabetic Male Rat. Iran J Vet Med. 2021;15:411-22.
  9. Moghtadaei Khorasgani, E., Khani, A. Investigating the Effect of Hydroalcoholic Extract of Eryngos on Plasma Concentration of Blood Glucose, Blood Cells and Pancreatic Tissue in Diabetic Rats. Iran J Vet Med. 2021;15:440-51.
  10. Erejuwa OO, Gurtu S, Sulaiman SA, Ab Wahab MS, Sirajudeen KN, Salleh MS. Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res. 2010;80:74-82.
  11. Nasrolahi O, Heidari R, Rahmani F, Farokhi F. Effect of natural honey from Ilam and metformin for improving glycemic control in streptozotocin-induced diabetic rats. Avicenna J Phytomed. 2012;2:212-21.
  12. Salrian AA, Behzadi A, Oloumi MM, Farajli Abbasi M, Delshad S, Moghadaszadeh M. Amplification of wound healing by propolis and honey ointment in healthy and diabetic rat models; histopathological and morphometric findings. Arch Razi Inst. 2022;77:1673-81.
  13. Erejuwa OO, Akpan JL, Uwaezuoke NI, Nwobodo NN, Ezeokpo BC, Erhirhie E, et al. Effects of honey on postprandial hyperlipidemia and oxidative stress in Wistar rats: Role of HMG-CoA reductase inhibition and postprandial oxidative stress in Wistar rats. Nig J Physiol Sci. 2018;33:129-38.
  14. Rajab AMA, Hamed RHT, Aly AM, Refat AA. Glycemic and insulinemic response of different types of Jordanian honey in healthy and type 2 diabetic volunteers. Pak J Nutr. 2017;6:61-8.
  15. Hiyoshi T, Fujiwara M, Yao Z. Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes. J Biomed Res. 2017;33:1-16.
  16. Erejuwa OO, Nwobodo NN, Akpan JL, Okorie UA, Ezeonu CT, BC, Nwadike KI, Erhiano E, Wahab MS, Sulaiman SA. Nigerian honey ameliorates hyperglycemia and dyslipidemia in alloxan-induced diabetic rats. Nutrients. 2016;8:95.
  17. Erejuwa OO, Ezeokpo BC, Nwobodo NN, Asika EC, Nwadike KI, Uwaezuoke NI, Nwachukwu DC, Ude NU, Wahab MS, Sulaiman SA. Effect of honey on body weight, body mass index and adiposity in high-fat diet fed wistar rats. EC Pharm Toxicol. 2017;3:3-12.
  18. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008;51:216-26.
  19. Ludwig DS, Hu FB, Tappy L, Brand-Miller J. Dietary carbohydrates: role of quality and quantity in chronic disease. BMJ. 2018;361:k2340.
  20. Abdulrhman M, El Hefnawy M, Ali R, Abdel Hamid I, Abou El-Goud A, Refai D.. Effects of honey, sucrose, and glucose on blood glucose and C-peptide in patients with type 1 diabetes mellitus. Complement Ther Clin Pract. 2013;19:15-9.
  21. Erejuwa OO. Honey: profile and features: application to diabetes. In: Watson RR, Preedy (Eds), Bioactive Food As Dietary Interventions for Diabetes (2nd edn). London Elsevier. 2019; pp. 461-94.
  22. Bahrami M, Ataie-Jafari A, Hosseini S, Foruzanfar MH, Rahmani M, Pajouhi M. Effects of natural honey consumption in diabetic patients: An 8-week randomized clinical trial. Int J Food Sci Nutr. 2009;60:618-26.
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