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Sungar, Samprita, Toragall, Makhadumsab, M A, Mujeeb, Puranik, Sridevi, A, Aimen, Aladkatti, Ravindranath, Ghagane, Shridhar. (1402). Phytochemical Analysis, Antimicrobial and Anti-Inflammatory Efficacy of Leucas aspera Leaf Extracts.. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2024.363633.2871
Samprita Sungar; Makhadumsab M Toragall; Mujeeb M A; Sridevi I Puranik; Aimen Akbar A; Ravindranath Aladkatti; Shridhar C. Ghagane. "Phytochemical Analysis, Antimicrobial and Anti-Inflammatory Efficacy of Leucas aspera Leaf Extracts.". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2024.363633.2871
Sungar, Samprita, Toragall, Makhadumsab, M A, Mujeeb, Puranik, Sridevi, A, Aimen, Aladkatti, Ravindranath, Ghagane, Shridhar. (1402). 'Phytochemical Analysis, Antimicrobial and Anti-Inflammatory Efficacy of Leucas aspera Leaf Extracts.', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2024.363633.2871
Sungar, Samprita, Toragall, Makhadumsab, M A, Mujeeb, Puranik, Sridevi, A, Aimen, Aladkatti, Ravindranath, Ghagane, Shridhar. Phytochemical Analysis, Antimicrobial and Anti-Inflammatory Efficacy of Leucas aspera Leaf Extracts.. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2024.363633.2871

Phytochemical Analysis, Antimicrobial and Anti-Inflammatory Efficacy of Leucas aspera Leaf Extracts.

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 اسفند 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2024.363633.2871
نویسندگان
Samprita Sungar1؛ Makhadumsab M Toragall2؛ Mujeeb M A3؛ Sridevi I Puranik4؛ Aimen Akbar A5؛ Ravindranath Aladkatti6؛ Shridhar C. Ghagane* 7
1Department of Biotechnology, KAHER's Dr. Prabhakar Kore Basic Science Research Centre, JNMC Campus, Belagavi-590010, Karnataka, India.
2Department of Applied Genetics, Karnatak University, Dharwad, Karnataka, India.
3Department of Biotechnology, Khaja Bandanawaz University, Kalaburgi, Karnataka, India.
4Department of Zoology, KLES Basavaprabhu Kore Arts, Science and Commerce College, Chikodi, Karnataka, India.
5Department of Parasitology, McGill University, Montreal, Quebec, Canada.
6Central Animal Facility, Indian Institute of Science, Bengaluru, Karnataka, India.
7KAHER’s Dr. Prabhakar Kore Basic Science Research Centre, Belagavi, Karnataka, India
چکیده
Medicinally, Leucas aspera has been confirmed to comprise broader pharmacological effectiveness viz., antioxidant, insecticide, antipyretic, chronic rheumatism, and cytotoxic activity etc. This plant is traditionally employed in the treatment of common infections viz., sore eyes and nose, fever, cough, skin eruptions, cold, wounds and sore throats. In this study, we intended to screen phytochemical constituents, evaluate the antimicrobial and anti-inflammatory capacities of different solvent extracts of Leucas aspera leaves. Leucas aspera leaves were collected, shade dried, fine powdered and subjected to phytochemical extraction using methanol, ethanol, water and hydroalcohol. From the extracts, phenol content was estimated by Folin-Ciocalteau reagent method followed by antimicrobial activity by Kirby-Bauer and Micro dilution assay with four different pathogenic bacteria. Later, anti-inflammatory activity was performed by various enzymatic assays. Phytochemical screening of Leucas aspera extract confirmed the presence of alkaloids, flavonoids, phenols, and tannins. The hydroalcoholic (MIC:12.5 µg/ml; MBC: 25µg/ml) and ethanolic (MIC:6.25 µg/ml; MBC:12.5 µg/ml) extracts presented effective antimicrobial activity against Escherichia coli, Staphylococcus aureus, Streptococcus mutants, and Propionibacterium acne. Amongst in vitro anti-inflammatory assays, hydroalcoholic extracts offered effective albumin denaturation (183.8±31.6µg/ml), heat induced haemolysis (213.4±22.3µg/ml) and considerable hypotonicity induced haemolysis (277.8±29.9µg/ml). The results were expressed as mean ± standard deviation and statistical interpretation was based on two-sided tests at a p ≤ 0.05 significance level. In this current study, it observed that Leucas aspera holds a variety of valuable secondary metabolites, which embraces strong anti-microbial and anti-inflammatory activities, however further studies are necessary to assess its therapeutic use. . On the basis of existing experimentations, corresponding outcomes may set the foundation for impending research.
کلیدواژه‌ها
Anti-Inflammatory؛ Anti-microbial؛ Leucas aspera؛ Medicinal plant؛ Phytochemical
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تعداد مشاهده مقاله: 106


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