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H. Mohamed, Asma'a, S. AlKhafaji, Rafie, H. Al-Saadi, Ali. (1402). Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.357805.2102
Asma'a H. Mohamed; Rafie S. AlKhafaji; Ali H. Al-Saadi. "Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2022.357805.2102
H. Mohamed, Asma'a, S. AlKhafaji, Rafie, H. Al-Saadi, Ali. (1402). 'Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.357805.2102
H. Mohamed, Asma'a, S. AlKhafaji, Rafie, H. Al-Saadi, Ali. Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2022.357805.2102

Correlation between vitamin D deficiency and vitamin D receptor (FokI-rs2228570) gene polymorphisms of Anemic Men in Babylon Province

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 بهمن 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357805.2102
نویسندگان
Asma'a H. Mohamed* 1؛ Rafie S. AlKhafaji2؛ Ali H. Al-Saadi3
1Al-Mustaqbal University College
2Faculty of Science/University of Kufa
3College of Science, University of Babylon/Iraq
چکیده
Vitamin D or calciferol, is a fat soluble vitamin that has a unique feature as it considered as the only vitamin that synthesizing in the body, primarily by exposition to UV-light from the sun and then is transformed to 25(OH)D by lever and finally to a vital form 1,25-dihydroxy D by the kidney. Gene polymorphism of vitamin D receptor (FokI-rs2228570) gene has been proposed as the major cause of anemia. The goal of this research was to discover the link between vitamin D insufficiency and the gene polymorphism for vitamin D receptor (FokI-rs2228570) in anemic patients. A case-control study including 120 men anemic patients without any kidney disorders have been compared with 60 healthy men as a control. One single nucleotide polymorphism (SNP) FokI-rs2228570 was detected by "PCR and PCR-RFLP" techniques. Serum vitamin D, erythropoietin levels and some biochemical parameters were detected by ELISA. The mutant homozygous genotype ff were more frequent in anemic patients (45%) than control (15%), also the f allele frequency were the common allele in patients group (0.62%) with significant decrement of vitamin D and hemoglobin levels, this mean that the presence of mutant allele represent the risk factor for developing anemia compared with genetic patterns FF and Ff. Vitamin D insufficiency is It's common in anemic people, and it's often accompanied by low hemoglobin and high erythropoietin levels. Additionally, the genetic frequencies also affect vitamin D conditions as indicated by low levels in mutant patterns (Ff, ff) in which the patients suffer from severe anemia.
کلیدواژه‌ها
vitamin D؛ vitamin D insufficiency؛ Anemia؛ vitamin D receptor gene polymorphism
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تعداد مشاهده مقاله: 13


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