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Antihypertensive and Antiobesity Activities of Selected Plants from Albay and Sorsogon Philippines | ||
| Journal of Medicinal plants and By-Products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 28 بهمن 1402 اصل مقاله (375.23 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2024.364241.1631 | ||
| نویسندگان | ||
| Lilibeth Ase Cajuday* 1؛ Ivane N Malaluan2؛ Phil V Morano1؛ Jocelyn E Serrano1؛ Jazzlyn T Imperial1 | ||
| 1Biology Department, College of Science Bicol University, Albay 4500 Philippines | ||
| 2Chemistry Department, College of Science Bicol University, Albay 4500 Philippines | ||
| چکیده | ||
| The present study evaluated the antihypertensive and antiobesity activities of twenty-three (23) selected plants from biodiverse sites in Albay and Sorsogon Philippines. In vitro antihypertensive and antiobesity activities of the plant extracts were screened using angiotensin-1 converting enzyme (ACE) and porcine pancreatic lipase (PPL) inhibition assays. The safety of the bioactive extracts was also evaluated using organ-specific toxicity assays. A total of five plants were potent ACE inhibitors (>70%) at 100 ppm concentration. The IC50 values of the bioactive extracts (50.77 to 67.94 ug/mL) were comparable to the potent drug Captopril (53.35 ug/mL). Seven plants were active against the PPL enzyme at 100 ppm concentration. Three plants exhibited strong PPL inhibitory activity (>70) with IC50 values of 46.1 to 53.45 ug/mL, less than half the value computed for Orlistat (96.04 ug/mL), indicative of its strong potential as an antiobesity agent. Cytotoxicity results revealed that all the bioactive plant extracts were non-toxic and safe. The study's findings are very promising in the search for potential herbal drugs against hypertension and obesity from natural sources in the region. | ||
| کلیدواژهها | ||
| ACE activity؛ Pancreatic lipase؛ CVDs؛ Herbal drug | ||
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