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Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. (1403). Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice. سامانه مدیریت نشریات علمی, 13(4), 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Foroogh Mirzania; Iraj Salimikia; Javad Ghasemian Yadegari; Alireza Nazarzadeh; Hossein Najmaddini. "Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice". سامانه مدیریت نشریات علمی, 13, 4, 1403, 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. (1403). 'Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice', سامانه مدیریت نشریات علمی, 13(4), pp. 1111-1117. doi: 10.22034/jmpb.2024.363350.1598
Mirzania, Foroogh, Salimikia, Iraj, Ghasemian Yadegari, Javad, Nazarzadeh, Alireza, Najmaddini, Hossein. Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice. سامانه مدیریت نشریات علمی, 1403; 13(4): 1111-1117. doi: 10.22034/jmpb.2024.363350.1598

Investigating the Effect of Acute and Subacute Toxicity of Ferula macrocolea (Boiss.) Boiss Essential Oil in BALB/c Mice

Journal of Medicinal plants and By-Products
مقاله 21، دوره 13، شماره 4، اسفند 2024، صفحه 1111-1117    اصل مقاله (928.44 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2024.363350.1598
نویسندگان
Foroogh Mirzania* 1، 2؛ Iraj Salimikia* 2؛ Javad Ghasemian Yadegari2؛ Alireza Nazarzadeh3؛ Hossein Najmaddini3
1Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2Department of Pharmacognosy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Lorestan, Iran
3Faculty of Pharmacy, Lorestan University of Medical Sciences, Lorestan, Iran
چکیده
This research was conducted to evaluate the acute and subacute toxicity of Ferula macrocolea essential oil on blood and serum biochemical parameters in BALB/c mice. To determine acute toxicity, four groups of mice (each comprising 6 mice) received a single oral dose of 1.24 ml/kg of F. macrocolea essential oil. Subacute toxicity was assessed by examining vital organs such as the liver, kidneys, and blood parameters after administering doses (0.1, 0.2, 0.4, and 0.6 ml/kg) of the plant essential oil orally for 28 days. The results of acute toxicity studies, where a single dose of 1.24 ml/kg of plant essential oil was orally administered to the mice, were monitored for 28 days. The median lethal dose (LD50) of this compound was determined to be 1.79 ml/kg. In the study of acute toxicity, conducted with a dose of 1.24 ml/kg, no cases of animal death were observed. Additionally, in the study of subacute toxicity with doses of (0.1, 0.2, 0.4, and 0.6 ml/kg), no toxic effects on vital organs such as the liver and kidneys, as well as blood parameters, were observed. Finally, none of the blood parameters and histological characteristics of the studied organs were altered by the consumption of F. macrocolea essential oil. Therefore, it exhibits no significant toxicity and can be considered for potential effects on various diseases in future studies.
کلیدواژه‌ها
Ferula macrecolea (Boiss.) Boiss؛ Toxicity؛ Acute toxicity؛ Subacute toxicity؛ LD50
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