Anti-diabetic Effects of Caucasian whortleberry and Ferula Extract on Blood Biochemical Factors, Liver and Kidney Histology in Streptozotocin-induced Diabetic Mice
|Journal of Medicinal plants and By-product
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|نوع مقاله: Research Paper
|شناسه دیجیتال (DOI): 10.22034/jmpb.2024.363857.1621
Zaynab Sanei1؛ Hamid Mollania2؛ Nasrin Mollania* 1؛ Toktam Hajjar1؛ Aliakbar Jannatabadi3
|1Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
|2Department of Electrical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
|3Department of Biology, Sabzavar Branch, Islamic Azad University, Sabzavar, Iran
|One of the biggest issues facing modern societies is diabetes, which is becoming more prevalent as a result of changes in daily routines. Numerous studies are currently being conducted to determine the impact of herbal medications on diabetes, given the negative side effects of chemical treatments used to treat the condition. The present study aimed to compare the antidiabetic effects of Caucasian whortleberry methanolic extract and Ferula brewed extract (Ferula tea). To this end, 40 mice were given 200 mg/kg of streptozotocin intraperitoneally to induce diabetes in them. The mice were then divided into six groups, each consisting of ten mice: Group 1 included healthy mice that did not receive any treatment and was mentioned as the control; Group 2 was considered the diabetic control group and received a daily treatment of water; Group 3 and 4 received a daily treatment of the chemical drugs Acarbose or Metformin, which are regularly and separately used at a dose of 100 mg/kg of each drug. Group 5 received a daily treatment of 250 mg/kg of Caucasian whortleberry methanolic extract, and group 6 received a daily treatment of 300 mg/kg of Ferula tea. After the 40-day trial, the results showed that Caucasian whortleberry methanolic extract, Ferula tea, and Acarbose significantly reduced serum glucose levels compared to the control. In addition, Caucasian whortleberry methanolic extract caused a significant reduction in triglycerides and alkaline phosphatase.
Abbreviations: STZ: Streptozotocin, HDL: High-Density Lipoproteins, LDL: Low-Density Lipoproteins, SGOT: Serum Glutamic Oxaloacetic Transaminase, ALP: Alkaline Phosphatase, HbA1c: Hemoglobin A1c, SGPT: Serum Glutamic Pyruvic Transaminase, CGA: Chlorogenic Acid. FBS: Fast Blood Sugar.
Caucasian whortleberry Methanolic Extract؛ Anti-diabetic Effects؛ Streptozotocin-induced Diabetic Mice؛ Ferula Tea؛ Medical Plants
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