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Khodadadi, Hanie, Khaledi, Sajed, Mehdinezhad Roshan, Mehdi, Eslampour, Mohammadamin, Moradi, Soraya, Mortazavi, Pejman. (1403). Efficacy of Salvia Officinalis Extract Against Infertility in Oxidative Stress Conditions. سامانه مدیریت نشریات علمی, 13(3), 629-636. doi: 10.22034/jmpb.2023.363418.1600
Hanie Khodadadi; Sajed Khaledi; Mehdi Mehdinezhad Roshan; Mohammadamin Eslampour; Soraya Moradi; Pejman Mortazavi. "Efficacy of Salvia Officinalis Extract Against Infertility in Oxidative Stress Conditions". سامانه مدیریت نشریات علمی, 13, 3, 1403, 629-636. doi: 10.22034/jmpb.2023.363418.1600
Khodadadi, Hanie, Khaledi, Sajed, Mehdinezhad Roshan, Mehdi, Eslampour, Mohammadamin, Moradi, Soraya, Mortazavi, Pejman. (1403). 'Efficacy of Salvia Officinalis Extract Against Infertility in Oxidative Stress Conditions', سامانه مدیریت نشریات علمی, 13(3), pp. 629-636. doi: 10.22034/jmpb.2023.363418.1600
Khodadadi, Hanie, Khaledi, Sajed, Mehdinezhad Roshan, Mehdi, Eslampour, Mohammadamin, Moradi, Soraya, Mortazavi, Pejman. Efficacy of Salvia Officinalis Extract Against Infertility in Oxidative Stress Conditions. سامانه مدیریت نشریات علمی, 1403; 13(3): 629-636. doi: 10.22034/jmpb.2023.363418.1600

Efficacy of Salvia Officinalis Extract Against Infertility in Oxidative Stress Conditions

Journal of Medicinal plants and By-Products
مقاله 18، دوره 13، شماره 3، آذر 2024، صفحه 629-636    اصل مقاله (1.35 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.363418.1600
نویسندگان
Hanie Khodadadi1؛ Sajed Khaledi2؛ Mehdi Mehdinezhad Roshan3؛ Mohammadamin Eslampour4؛ Soraya Moradi1؛ Pejman Mortazavi* 5
1Graduated of Veterinary Medicine, Faculty of veterinary medicine, Science and research branch, Islamic azad university, Tehran, Iran
2Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Biology and Anatomical Sciences, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of clinical sciences, Faculty of veterinary medicine, Science and research branch, Islamic azad university, Tehran, Iran
5Department of pathology, Faculty of veterinary medicine, Science and research branch, Islamic azad university, Tehran, Iran
چکیده
This study aimed to investigate the effects of Salvia officinalis L. extract on infertility of male rats. In this experimental study, 40 rats were used in 8 groups and cadmium chloride was also used to induce infertility. S. officinalis extract was fed to mice daily for 28 days with the help of gavage needle. Animals were anesthetized with ether and dissected, then epididymal sperm were examined for morphology, viability and motility. we analyzed their right testis for H/E staining and counting cell lines and their left testicles were analyzed to evaluate superoxide dismutase (SOD) and malondialdehyde (MDA) enzymes.
According to the ‌‌‌results of three sperm quality analyses indicated a significant increasing of viability, motility and the number of sperm cells in infertile groups treated with 100, 200, and 400 mg/kg S. officinalis extract (P<0.001). Our SOD analysis revealed Salvia Officinalis extract caused to produce more enzymes in the healthy experimental groups, even compared to the healthy control group (P<0.0001). our ‌‌analysis indicated that increasing the dosage of the S. officinalis extract resulted in increasing enzyme production in infertile groups. MDA analyses showed that the healthy experimental groups produced a lower amount of MDA enzyme, which is almost the same level as the healthy control group (P<0.0001). Due to the usage of S. officinalis extract, the level of lipid peroxidation and MDA significantly decreased. In this study, S. officinalis extract can have significant positive impacts on the viability, motility, number of sperms in oxidative stress conditions.
کلیدواژه‌ها
Salvia officinalis؛ Infertility؛ Cadmium chloride؛ Oxidative stress
مراجع
  1. Mbaye M.M., El Khalfi B., Addoum B., Mar P.D., Saadani B., Louanjli N., et al. The effect of supplementation with some essential oils on the mobility and the vitality of human sperm. The Scientific World J. 2019;2019.
  2. Mbaye M.M., El Khalfi B., Ouzamode S., Saadani B., Louanjli N., Soukri A. Effect of Origanum vulgare essential oil supplementation on the advanced parameters of mobility and on the integrity of human sperm DNA. International J. Reproductive Medicine. 2020;2020.
  3. Djerrou Z., Benyezzar-Kenana H., Maameri Z., Benhamza L. An ethnopharmacological survey of medicinal plants used in the traditional treatment of human infertility in eastern Algeria. Asian Pacific J. Reproduction. 2022;11(2):77.
  4. CHOUABIA A., DJEMLI S., ABDENNOUR C., MALLEM L., KAHALERRAS L., ARKOUB FZ, et al. Protective effect of Salvia officinalis against cypermethrininduced reprotoxicity in male Wistar rats. Pharmacognosy Journal. 2021;13(6).
  5. Mohsin A.S., Eidan S.M. Effect of adding antioxidants to Tris extender on cooling and post-Cryopreservative semen characteristics of Holstein bulls 2. Salvia Officinalis L Aqueous extract. Biochem Cell Arch. 2019;19(1):1157-64.
  6. Pezo F., Yeste M., Zambrano F., Uribe P., Risopatrón J., Sánchez R. Antioxidants and their effect on the oxidative/nitrosative stress of frozen-thawed boar sperm. Cryobiology. 2021;98:5-11.
  7. Davoodi F., Taheri S., Raisi A., Rajabzadeh A., Ahmadvand H., Hablolvarid M.H., et al. Investigating the sperm parameters, oxidative stress and histopathological effects of Salvia miltiorrhiza hydroalcoholic extract in the prevention of testicular ischemia reperfusion damage in rats. Theriogenology. 2020;144:98-106.
  8. Greifova N.L. Investigation of the properties and effects of Salvia officinalis L. on the viability, steroidogenesis and reactive oxygen species (ROS) production in TM3 Leydig cells in 2 vitro 3.
  9. Bresm M.H.A., Habeeb H.M.H., editors. Effect of Adding Different Vitamin D3 Concentrations on Chilled Storage of Awassi Ram Semen. IOP Conference Series: Earth and Environmental Sci. 2022: IOP Publishing.
  10. Abarikwu SO, Onuah CL, Singh SK. Plants in the management of male infertility. Andrologia. 2020;52(3):e13509.
  11. Alafid F., Edrah S.M., Meelad F.M., Belhaj S., Altwair K., Maizah N.R. Evaluation of phytochemical constituents and antibacterial activity of thymelaea hirsuta (l.) Endl, and that utilised as a conventional treatment of infertility and diabetic in Libya. World J. Pharmaceutical Res. 2019;8(11):72-88.
  12. Zhang Q., Fan L., Li F., Sun Z., Zhang C., Chen R. Yishentongluo decoction in treatment of idiopathic asthenozoospermia infertility: Study protocol for a randomized controlled trial. Medicine. 2020;99(43).
  13. Das S., Roychoudhury S., Dey A., Jha NK, Kumar D., Roychoudhury S., et al. Bacteriospermia and Male Infertility: Role of Oxidative Stress. Oxidative Stress and Toxicity in Reproductive Biology and Medicine: Springer. 2022. p. 141-63.
  14. Diab K.A., Fahmy M.A., Hassan Z.M., Hassan E.M., Salama A.B., Omara E.A. Genotoxicity of carbon tetrachloride and the protective role of essential oil of Salvia officinalis L. in mice using chromosomal aberration, micronuclei formation, and comet assay. Environmental Sci and Pollution Res. 2018;25(2):1621-36.
  15. El‐Wakf A.M., El‐Habibi E.S.M., Ali D.A., Abd El‐Ghany E., Elmougy R. Marjoram and sage oils protect against testicular apoptosis, suppressed Ki‐67 expression and cell cycle arrest as a therapy for male infertility in the obese rats. J. Food Biochemistry. 2020;44(1):e13080.
  16. El-Defrawy SH.S., Sobhy H.M., El-Kholy T.A., El-Hashash S.A., Sultan H.A. Protective Effect of Moringa and Sage on Fertility Impairment Induced by Synthetic Pyrethroids in Male Rats. Egyptian Journal of Chemistry and Environmental Health. 2020;6(2):13-27.
  17. Fahmy M.A., Abd-Alla H.I., Hassan E.E., Hassan Z.M., Heba-tollah M.S. Genotoxicity and sperm defects induced by 5-FU in male mice and the possible protective role of Pentas lanceolata-iridoids. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2020;850:503145.
  18. KARAYEL H.B. Effects of natural boron mineral on the essential oil ratio and components in medicinal sage (Salvia officinalis L.). Cumhuriyet Science J. 2021;42(2):269-75.
  19. Adeldust H., Farzinpour A., Farshad A., Rostamzadeh J., Béjar M.L. Effect of orally administrated letrozole on reproduction performance and gene expression of FOXJ1, LPR2 and PVRL3 in reproductive tract in aged roosters. Theriogenology. 2021;161:131-9.
  20. Krepkova L.V., Bortnikova V.V., Babenko A.N., Mizina P.G., Mkhitarov V.A., Job K.M., et al. Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development. BMC Complementary Medicine and Therapies. 2021;21(1):1-9.
  21. Duracka M., Lukac N., Kacaniova M., Kantor A., Hleba L., Ondruska L., et al. Antibiotics versus natural biomolecules: The case of in vitro induced bacteriospermia by enterococcus faecalis in rabbit semen. Molecules. 2019;24(23):4329.
  22. Juárez‐Rojas L., Casillas F., López A., Betancourt M., Ommati M.M., Retana‐Márquez S. Physiological role of reactive oxygen species in testis and epididymal spermatozoa. Andrologia. 2022;54(4):e14367.
  23. Shi Y-Q., Wang Y., Zhu X-T., Yin R-Y., Ma Y-F., Han H., et al. The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility. Evidence-Based Complementary and Alternative Medicine. 2022;2022.
  24. Darestani A. Effect of Vitamins C and E on Some Sperm Characteristics in Varamini Rooster in Cold Conditon. Res. On Animal Production (Scientific and Res). 2019;10(24):66-75.
  25. Raisi A., Davoodi F., Mohammadi R. Protective Effects of Rosmarinic Acid on Testicular Torsion-Detorsion in an Animal Model. Iranian J. Veterinary Surgery. 2022:80-6.
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