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| تعداد نشریات | 283 |
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Antinociceptive and anti-inflammatory activities of Ferula elaeochytris Korovin methanolic extract in rat model | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 آذر 1402 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2023.363683.2883 | ||
| نویسندگان | ||
| Abdolhakim Jadgalradeh* ؛ Mudassar Iqbal | ||
| Department of Pharmacy Practice, Faculty of Pharmacy, University of Sindh Jamshoro, Pakistan | ||
| چکیده | ||
| Today, the current chemical agents for pain control have relatively many complications. They are associated with the occurrence of disorders in the digestive system, kidney damage, or addiction, which has caused people to find newer drugs that, in addition to removing side effects, are cheap and available. The present in vivo survey aimed to assess the antinociceptive and anti-inflammatory activity of Ferula elaeochytris Korovin methanolic extract (FEME) in male Swiss mice. After obtaining the methanolic extract through the maceration process, the antinociceptive efficacy of FEME at doses of 25 to 100 mg/kg was assessed by the tail-flick, hot-plate, and formalin tests. In addition, anti-inflammatory evaluation was performed by the Carrageenan-induced paw edema model. We found that in the tail-flick and hot plate test, FEME mainly at the dose of 100 mg/kg significantly reduced the latency time as well as better the time of the observance of licking or jumping in comparison with normal saline (P<0.001). We reported that FEME at 50, and 100 mg/kg considerably declined the pain behaviors in the acute and chronic phase in comparison with normal saline (p<0.001). FEME markedly (p < 0.05) declined paw edema in a dose- and time-dependent response, so a significant difference was observed in paw edema followed by treatment with FEME at 50 and 100 mg/kg (p<0.001). To conclude, this study reported the potent analgesic and inflammatory effects of F. elaeochytris methanolic extract to control peripheral and central pain. However, additional experiments are mandatory to clear the accurate mechanisms of action of this plant. | ||
| کلیدواژه‌ها | ||
| analgesic؛ inflammation؛ natural products؛ in vivo؛ pain | ||
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