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Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. (1403). Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease. سامانه مدیریت نشریات علمی, 79(3), 629-638. doi: 10.32592/ARI.2024.79.3.629
Zainab Alimoradi; Farzaneh Taghian; Khosro Jalali Dehkordi. "Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease". سامانه مدیریت نشریات علمی, 79, 3, 1403, 629-638. doi: 10.32592/ARI.2024.79.3.629
Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. (1403). 'Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease', سامانه مدیریت نشریات علمی, 79(3), pp. 629-638. doi: 10.32592/ARI.2024.79.3.629
Alimoradi, Zainab, Taghian, Farzaneh, Jalali Dehkordi, Khosro. Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease. سامانه مدیریت نشریات علمی, 1403; 79(3): 629-638. doi: 10.32592/ARI.2024.79.3.629

Effect of Linalool, Cineole, and β-Bourbonene Coupled with Aerobic Training on the Improvement of Presenilin-1/Amyloid Protein Precursor/Interleukin-1 beta/CASPASE 1 Network, Oxidative Capacity, and miRNA-210 in Mice with Alzheimer's Disease

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مقاله 24، دوره 79، شماره 3، مرداد و شهریور 2024، صفحه 629-638    اصل مقاله (753.37 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.3.629
نویسندگان
Zainab Alimoradi1؛ Farzaneh Taghian* 2؛ Khosro Jalali Dehkordi3
1Ph.D. student, Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
2Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
3Assistant professor, Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
چکیده
Alzheimer's is an advanced nervous disorder related to aging. This research aims to determine the effect of eight weeks of aerobic training and linalool, cineole, and β-Bourbonene on preventing and improving Alzheimer's disease. Mice randomly divided into 8 groups: Control group, Mice induced Alzheimer's disease treating with β-amyloid (Alzheimer group), Alzheimer's mice were treated with bioactive compounds of herbal medicine (Linalool with a concentration of 25 mg/kg, Cineol with a concentration of 100 mg/kg, β-Bourbonene with a concentration of 0.20 μg by gavage for 8 weeks, Alzheimer+Biocompounds group), Alzheimer's mice treated with aerobic exercise with a moderate intensity treadmill for 8 weeks (Alzheimer's+Training group), Alzheimer's mice treated with bioactive compounds of herbal medicine and aerobic exercise for 8 weeks (Alzheimer+Biocompounds+Training group), Healthy mice were first treated with the bioactive compounds of the herbal medicine, and then were induced with Alzheimer's (Biocompounds+Alzheimer group), Healthy mice were first treated with aerobic exercise using a treadmill with moderate intensity for 8 weeks and then induced Alzheimer's disease (Training+Alzheimer group), Healthy mice were first treated with the bioactive compounds of the herbal medicine and aerobic exercise for 8 weeks and then induced Alzheimer's disease (Biocompounds+Training+Alzheimer group). Compared to other groups, the IL1β/CASP3/PSEN1/APP level improved in mice first treated with aerobic exercise and biocompounds. Oxidative capacity was improved by exercise training and bioactive compounds. In addition, exercise training and bioactive compounds regulated the miRNA-210 in the hippocampus of the mice with Alzheimer's. We could conclude that consuming biocompounds and aerobic training can manage and prevent Alzheimer's.
کلیدواژه‌ها
Alzheimer؛ aerobic exercise؛ herbal compounds؛ Biocompounds
عنوان مقاله [English]
تاثیر لینالول، سینائول، بتا بوربونین همراه با تمرین هوازی سبب بهبود شبکه‌های PSEN1/APP/IL1β/CASP3، ظرفیت اکسیداتیو و miRNA-210 را در موش‌های مبتلا به بیماری آلزایمر.
چکیده [English]
آلزایمر یک اختلال عصبی پیشرفته مرتبط با افزایش سن است. این تحقیق با هدف تعیین تأثیر هشت هفته تمرین هوازی و مصرف لینالول، سینائول، بتا بوربونین بر پیشگیری و بهبود بیماری آلزایمر انجام شد. موش‌ها به‌طور تصادفی به 8 گروه تقسیم شدند: گروه کنترل، موش‌های آلزایمر تحت درمان با بتا آمیلوئید (گروه Alzheimer)، موش‌های آلزایمر با ترکیبات زیست فعال داروی گیاهی (لینالول با غلظت 25 میلی‌گرم بر کیلوگرم، سینائول با غلظت 100 میلی گرم بر کیلوگرم و بتا بوربونن با غلظت 0.2 میکروگرم به صورت گاواژ به مدت 8 هفته، گروه Alzheimer+Biocompounds)، موش های آلزایمر تحت درمان با ورزش هوازی با تردمیل با شدت متوسط به مدت 8 هفته) گروه Alzheimer's+Training )، موش های آلزایمر تحت درمان با ترکیبات زیست فعال داروی گیاهی و ورزش هوازی به مدت 8 هفته (گروه Alzheimer+Biocompounds+Training)، موش های سالم ابتدا با ترکیبات زیست فعال داروی گیاهی تحت درمان قرار گرفتند و سپس آلزایمر القا شدند (گروه Biocompounds+Alzheimer)، موش های سالم ابتدا با استفاده از تردمیل با شدت متوسط به مدت 8 هفته تحت درمان با ورزش هوازی قرار گرفتند و سپس به بیماری آلزایمر القاء شدند (گروه Training+Alzheimer)، موش های سالم ابتدا با ترکیبات زیست فعال داروی گیاهی و ورزش هوازی تحت درمان قرار گرفتند (گروه Biocompounds+Training+Alzheimer). سطح L1β/CASP3/PSEN1/APP در موش‌هایی که ابتدا با ورزش هوازی و ترکیبات زیستی تحت درمان قرار گرفتند در مقایسه با سایر گروه‌ها بهبود یافت. ظرفیت اکسیداتیو با تمرینات ورزشی و ترکیبات زیست فعال بهبود یافت. علاوه بر این، تمرینات ورزشی و ترکیبات زیست فعال، miRNA-210 را در هیپوکامپ موش‌های مبتلا به آلزایمر تنظیم کردند. می توان نتیجه گرفت که مصرف ترکیبات زیستی و تمرینات هوازی می تواند آلزایمر را مدیریت و از آن پیشگیری کند.
کلیدواژه‌ها [English]
آلزایمر, ورزش هوازی, ترکیبات گیاهی, ترکیبات زیستی
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