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Anti-fatigue and Anti-Oxidant Effects of Aqueous Extract of Echium amoenum on a Rat Model of Acute Fatigue | ||
| Journal of Medicinal plants and By-Products | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 آبان 1402 اصل مقاله (835.14 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2023.363436.1601 | ||
| نویسندگان | ||
| Fahimeh Safaeinejad1؛ Maliheh Soodi2، 3؛ Somayeh Esmaeili4؛ Fatemeh Jafari1؛ Maedeh Shirzad Kebria2؛ Behnaz Keramatian1؛ Homa Hajimehdipoor* 4؛ Sadegh Rajabi* 1 | ||
| 1Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1434875451, Iran | ||
| 2Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 3Institute of Natural Products and Medicinal Plants, Tarbiat Modares University, Tehran, Iran | ||
| 4Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1516745811, Iran | ||
| چکیده | ||
| Echium amoenum L. has been used for the management of the common cold, inflammation, depression, anxiety, and fatigue. This study aimed to explore the anti-fatigue and anti-oxidant effects of aqueous extract of E. amoenum (AEEA) on a rat model of acute fatigue. After preparing AEEA, 30 Wistar rats were divided into five groups of six animals. Group 1 received distilled water; Group 2 was treated with distilled water and underwent a forced swimming test (FST); Groups 3-5 rats were administered AEEA (250, 500, and 1000 mg/kg), and subsequently underwent FST. Then, the levels of some biochemical parameters and oxidative stress markers were measured in the serum and liver tissues of rats. AEEA treatment significantly augmented the swimming time of rats compared to the control group. AEEA-treated animals had increased serum glucose and decreased serum urea levels. AEEA diminished serum activities of creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Treating the rats with AEEA activated superoxide dismutase (SOD) and catalase (CAT), and decreased total oxidant status (TOS) in serum. AEEA increased the levels of thiols and glutathione (GSH) as well as the activity of glutathione peroxidase (GPx) and CAT in the liver tissues. In the liver tissue, AEEA also induced the activity of SOD and reduced TOS. These results may suggest AEEA as a potential anti-fatigue natural product to ameliorate the adverse effects of acute fatigue on the body. | ||
| کلیدواژه‌ها | ||
| Anti-oxidant؛ Echium amoenum؛ Fatigue؛ Forced swimming test؛ Oxidative stress؛ Rat | ||
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آمار تعداد مشاهده مقاله: 152 تعداد دریافت فایل اصل مقاله: 101 |
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