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Shabani, Mozhgan, Fallah Huseini, Hasan, Ghorbani Nohooji, Majid, Roghani, Mehrdad, Nasri, Sima. (1403). Total Phenolic and Flavonoid Contents and Hydro Alcoholic Extract of Polygonum aviculare L. Effects on Learning and Memory in a rat Model of Alzheimer Disease. سامانه مدیریت نشریات علمی, 13(3), 637-643. doi: 10.22034/jmpb.2023.362255.1558
Mozhgan Shabani; Hasan Fallah Huseini; Majid Ghorbani Nohooji; Mehrdad Roghani; Sima Nasri. "Total Phenolic and Flavonoid Contents and Hydro Alcoholic Extract of Polygonum aviculare L. Effects on Learning and Memory in a rat Model of Alzheimer Disease". سامانه مدیریت نشریات علمی, 13, 3, 1403, 637-643. doi: 10.22034/jmpb.2023.362255.1558
Shabani, Mozhgan, Fallah Huseini, Hasan, Ghorbani Nohooji, Majid, Roghani, Mehrdad, Nasri, Sima. (1403). 'Total Phenolic and Flavonoid Contents and Hydro Alcoholic Extract of Polygonum aviculare L. Effects on Learning and Memory in a rat Model of Alzheimer Disease', سامانه مدیریت نشریات علمی, 13(3), pp. 637-643. doi: 10.22034/jmpb.2023.362255.1558
Shabani, Mozhgan, Fallah Huseini, Hasan, Ghorbani Nohooji, Majid, Roghani, Mehrdad, Nasri, Sima. Total Phenolic and Flavonoid Contents and Hydro Alcoholic Extract of Polygonum aviculare L. Effects on Learning and Memory in a rat Model of Alzheimer Disease. سامانه مدیریت نشریات علمی, 1403; 13(3): 637-643. doi: 10.22034/jmpb.2023.362255.1558

Total Phenolic and Flavonoid Contents and Hydro Alcoholic Extract of Polygonum aviculare L. Effects on Learning and Memory in a rat Model of Alzheimer Disease

Journal of Medicinal plants and By-products
مقاله 19، دوره 13، شماره 3، آذر 2024، صفحه 637-643    اصل مقاله (1014 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.362255.1558
نویسندگان
Mozhgan Shabani1؛ Hasan Fallah Huseini2؛ Majid Ghorbani Nohooji2؛ Mehrdad Roghani3؛ Sima Nasri* 1
1Department of Biology, Payame Noor University, Tehran, Iran
2Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
چکیده
Alzheimer's disease via various pathways, including augmented oxidative stress accompanies disturbances in learning, memory and cognitive skills in the human society. The present study was conducted to evaluate the effect of Polygonum aviculare (P. aviculare) on learning and memory in streptozotocin induced Alzheimer in rats. Aerial parts of P.aviculare extracted by percolation method. Total phenolic and flavonoid contents were measured by colorimetric method. Fifty male wistar rats were divided into 5 groups: control, Alzheimer's group, and three groups Alzheimer's induced and P. aviculare treated. In order to evaluate of learning and memory, initial (IL) and step-through latencies (STL) tests were determined at the end of study using passive avoidance test and alternation behavior percentage was obtained using Y maze. Total phenolic contents of extract were 67.7 ± 6.3 mg/g and the total flavonoid content was 12.7 ± 1.3 mg/g. In behaviors test, there was no significant change in IL in Alzheimer's and P. aviculare treated Alzheimer's group as compared to control group. Meanwhile, STL significantly decreased in Alzheimer's group as compared to control group (p<0.005). The existing difference between Alzheimer's and P. aviculare Treated-Alzheimer's groups was statistically significant (p<0.01). Intraperitoneal injection of P. aviculare could enhance the capability of consolidation and recall in Alzheimer's animals treated, and improve spatial memory in Alzheimer's animals treated group using Y maze.
کلیدواژه‌ها
Polygonum aviculare؛ Learning؛ Memory؛ Alzheimer's rat
مراجع
  1. Hassanpour H,Pouyan A.A., Dehghan H. Detection of Alzheimer’s Disease Using Multitracer Positron. Emission Tomography Imaging.International J. Engineering2014;27(1): 51-56.
  2. Nagasako-Akazome Y., Kanda T., Ohtake Y., Shimasaki H., Kobayashi T. Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index. J Oleo Sci. 2007; 56(8):417-28.
  3. Zhi-Ru C., Jia-Bao H., Shu-Long Y., Fen-Fang H. Role of cholinergic signaling in Alzheimer’s disease. Molecules 2022; 27(6): 1816.
  4. Cooper E.L., Melissa J.M. Alzheimer Disease: Clues from traditional and complementary medicine.J. Tradit Complement Med. 2017;7(4):380–385.
  5. Arab L., Sabbagh M.N. Are certain life style habits associated with lower Alzheimer disease risk? J.Alzheimers Dis. 2010;20(3):785–794.
  6. Bushra S., Wei D., .Hussain A., Yeong S.K., Khan S. Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease. Front Pharmacol. 2018;9:548.
  7. FengY, Wang X. Antioxidant therapies for Alzheimer's disease. Oxid. Med. Cell Longev. 2012; 2012: 472932.
  8. Pawlowska K.A., Kryzman M., Zidorn C., Pagitz K., Popowski D., Granica S. HPLC-DAD-MS3 fingerprints of phenolics of selected Polygonum taxa and their chemometric analysis. Phytochemistry. 2023;208:113605.
  9. Habibi R.M., Mohammadi R.A., Delazar A, et al. Effects of polygonum aviculare herbal extract on proliferation and apoptotic gene expression of MCF-7. Daru. 2011;19(5):326-331.
  10. Akbar S. Polygonum avicular L. (Polygonaceae). In: handbook of 200 medicinal plants. Springer. Cham. https://doi.org/10.1007/978-3-030-16807-0_153.
  11. Sung Y.Y., Yoon T., Yang W.K., Kim S.J., Kim D.S., Kim H.K. The antiobesity effect of Polygonum aviculare L. ethanol extract in high-fat diet-induced obese mice. Evid. Based Complement. Alternat. Med. 2013, 2013, 626397.
  12. Granica S., Piwowarski J.P., Popławska M., Jakubowska M., Borzym J., Kiss A.K. Novel insight into qualitative standardization of Polygonia vicularis herba (Ph. Eur.). J. Pharm. Biomed. Anal. 2013;72:216–222.
  13. Cai Y., Wu L., Lin X., Hu X., Wang L. Phenolic profiles and screening of potential α-glucosidase inhibitors from Polygonum aviculare L. leaves using ultra-filtration combined with HPLC-ESI-qTOF-MS/MS and molecular docking analysis. Ind. Crop. Prod. 2020; 154, 112673
  14. Chin-Yuan H. Antioxidant activity of extract from Polygonum aviculare, L. Biol Res2006; 39(2): 281-288.
  15. Ghahreman, A. Colored Flora Iranica. Tehran: Tehran University. 1979; 87-89. [persian]
  16. Fu-Quan X., Yuan-Yuan F., Li-Yun G. Optimization of Extraction Process for Flavonoids from Polygonum aviculareL. Based on HPLC Quantitation. Food Sci. 2012; 33(14): 36-40.
  17. Kim D.O., Jeong S.W., Lee C.Y. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chemistry. 2003; 81: 321-326.
  18. Kyung Mi Y., Choong H.L., Hyungjae L., BoKyung M., Chang Yong L. Relative antioxidant and cytoprotective activities of common herbs. Food Chemistry. 2008; 106: 929-936.
  19. Nazari L., Komaki S., Salehi I., Raoufi S., Golipoor Z., Kourosh-Arami M., Komaki A. Investigation of the protective effects of lutein on memory and learning using behavioral methods in a male rat model of Alzheimer’s disease. J Functional Foods. 2022; 99:105319.
  20. Tayanloo-Beik A., Kiasalari Z., Roghani M. Paeonol ameliorates cognitive deficits in streptozotocin murine model of sporadic Alzheimer’s disease via attenuation of oxidative stress, inflammation, and mitochondrial dysfunction. J. Mol Neurosci. 2022; 72(2): 336-348.
  21. Grieb P. Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s disease: in Search of a Relevant Mechanism. Mol.Neurobiol. 2016; 53(3):1741–1752.
  22. Roghani M., Joghataie M.T., Jalili M.R., BaluchnejadmojaradT. Timecourse of changes in passive avoidance and Y-maze performance in male diabetic rats. IBJ. 2006; 10 (2):99-104.
  23. Ahshin-Majd S., Zamani S., Kiamari T., Kiasalari Z., Baluchnejadmojarad T., Roghani M. Carnosine ameliorates cognitive deficits in streptozotocin-induced diabetic rats: possible involved mechanisms. Peptides. 2016; 86:102-111.
  24. Kumar A., ArtiS Kavali E. A review on Alzheimer's disease pathophysiology and its management: an update. PharmacolRep. 2015; 67 (2): 195-203.
  25. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., Kowall N. Oxidative damage in Alzheimer’s. Nature. 1996; 382 (6587): 120-121.
  26. Vauzour D. Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects. Oxid Med Cell Longev. 2012; 2012: 914273.
  27. Ramezani M., Darbandi N., Khodagholi F., Hashemi A. Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease. Neural Regen Res. 2016;11(12): 1976-1980.
  28. Beg T., Jyoti S., Naz F., Ali F., Kashif Ali S., Reyad A.M., Siddique Y.H. Protective effect of kaempferol on the transgenic Drosophila model of Alzheimer’s disease. CNS Neurol Disord Drug Targets. 2018;17(6): 421-429. doi: 10.2174/1871527317666180508123050
  29. Khan H., Amin M.S., Ajmal Kamal M., Patel S. Flavonoids as acetycholiesterase inhibitors: Current therapeutic standing and future poospects. Biomedicine & pharmacotherapy. 2018; 101: 860-870. https://doi.org/10.1016/j.biopha.2018.03.007
  30. Jung M., Park M. acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa. Molecules. 2007; 12(9), 2130-2139.
  31. Yoon-Young S., TaesookY., Yang W., SeungJu K., Dong-Seon K., Ho Kyoung K. The Antiobesity Effect of PolygonumAviculare L. Ethanol Extract in High-Fat Diet-Induced Obese Mic. Evidence-Based complementary and alternative medicine. 2013;2013:626397.
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