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Protective Effects of the Phenolic-rich Fraction of Young Corn Silk (Zea mays L.) against Pancreatic Islet Destruction in Streptozotocin-induced Diabetic Rats | ||
| Journal of Medicinal plants and By-product | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 آبان 1402 اصل مقاله (658.04 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jmpb.2023.359722.1497 | ||
| نویسندگان | ||
| Nurraihana Hamzah1؛ Sabreena Safuan2؛ Wan Rosli Wan Ishak* 3 | ||
| 1Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. | ||
| 2Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia | ||
| 3Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia | ||
| چکیده | ||
| The phytochemical and bioactive characteristics of plants are influenced by their species and varieties. However, not much is known about the ability of baby corn silk in repairing pancreatic damage. In this study, we investigate the protective effects of the phenolic-rich fraction of vegetable variety baby corn silk (PRFsilk) on the pancreas of streptozotocin (STZ)-induced diabetic rats. Thirty rats were divided into five groups, where Group 1 comprised six nondiabetic control rats; Group 2 was diabetic control; Groups 3 and 4 were diabetic rats treated with 100 and 200 mg/kg/day of PRFsilk, respectively; and Group 5 served as diabetic treatment control with 150 mg/kg/day of metformin. After 28 days of administrating PRFsilk, diabetic rats in Groups 3 and 4 had their blood glucose levels significantly lowered by 67.45 % and 66.85 %, respectively, compared with the diabetic control group, with more insulin detected in their pancreatic homogenates through ELISA assay. The histological assessment found signs of damage and atrophy in the islet cells of all diabetic rats, with the worst observed in the diabetic control group. However, the islets of PRFsilk-treated rats had little damage caused by STZ induction compared with the pancreas of metformin-treated rats, particularly in Group 3, which was treated with a lower PRFsilk dose. This showed that the PRF of baby corn silk could ameliorate STZ-induced pancreatic damage in rats, most likely through its anti-oxidative and immune-boosting properties. | ||
| کلیدواژه‌ها | ||
| Corn silk؛ Phenolic fraction؛ Pancreas؛ Histology؛ Diabetic rats | ||
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آمار تعداد مشاهده مقاله: 91 تعداد دریافت فایل اصل مقاله: 46 |
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