اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,829
تعداد مقالات32,098
تعداد مشاهده مقاله40,862,930
تعداد دریافت فایل اصل مقاله18,112,542
Bahadeen Aref, Bakhan, Fakhri, Sajad, Morovati, Mohammad Reza, Ghanbari-Movahed, Maryam, Mohammadi Noori, Ehsan, Miraghaei, Shahram, Farzaei, Mohammad Hosein. (1403). Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer. سامانه مدیریت نشریات علمی, 13(3), 605-613. doi: 10.22034/jmpb.2023.362108.1548
Bakhan Bahadeen Aref; Sajad Fakhri; Mohammad Reza Morovati; Maryam Ghanbari-Movahed; Ehsan Mohammadi Noori; Shahram Miraghaei; Mohammad Hosein Farzaei. "Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer". سامانه مدیریت نشریات علمی, 13, 3, 1403, 605-613. doi: 10.22034/jmpb.2023.362108.1548
Bahadeen Aref, Bakhan, Fakhri, Sajad, Morovati, Mohammad Reza, Ghanbari-Movahed, Maryam, Mohammadi Noori, Ehsan, Miraghaei, Shahram, Farzaei, Mohammad Hosein. (1403). 'Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer', سامانه مدیریت نشریات علمی, 13(3), pp. 605-613. doi: 10.22034/jmpb.2023.362108.1548
Bahadeen Aref, Bakhan, Fakhri, Sajad, Morovati, Mohammad Reza, Ghanbari-Movahed, Maryam, Mohammadi Noori, Ehsan, Miraghaei, Shahram, Farzaei, Mohammad Hosein. Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer. سامانه مدیریت نشریات علمی, 1403; 13(3): 605-613. doi: 10.22034/jmpb.2023.362108.1548

Evaluating the Protective Effects of Aqueous and Hydroalcoholic Extracts of Plantago major Leaf in a Rat Model of Ethanol-induced Peptic Ulcer

Journal of Medicinal plants and By-Products
مقاله 15، دوره 13، شماره 3، آذر 2024، صفحه 605-613    اصل مقاله (1022.11 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.362108.1548
نویسندگان
Bakhan Bahadeen Aref1؛ Sajad Fakhri2؛ Mohammad Reza Morovati3؛ Maryam Ghanbari-Movahed2؛ Ehsan Mohammadi Noori2؛ Shahram Miraghaei4؛ Mohammad Hosein Farzaei* 2
1Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran
2Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran
3Persian Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran
4Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Science, Kermanshah, Iran
چکیده
There is usually a connection between the secretion of stomach acid and stomach ulcers, but today the main cause of these ulcers is considered to be the presence and proliferation of Helicobacter pylori bacteria, which causes peptic ulcers in various ways, including damage to the protective layer. Therefore, the aim of this study is to investigate the protective effect of the aqueous and hydroalcoholic extracts of Plantago major L. leaves on gastric ulcers induced by ethanol in rats. First, 36 adult male Wistar rats were selected and divided into 9 groups including famotidine and control groups, healthy groups, and protective groups that received the aqueous and hydroalcoholic extracts of the leaves of the P. major. After preparing and checking the obtained results, quantitative data was evaluated with a one-way analysis of variance and Tukey's post hoc test using SPSS software. The macroscopic examination results showed that in both groups receiving aqueous and hydroalcoholic extracts of the P. major plant, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. The general results of the present study showed that in both groups receiving the aqueous and hydroalcoholic extracts of the plant leaves, the group receiving the extract with a dose of 200 mg/kg had the best protective effect compared to the control group. In conclusion, our findings indicated that this extract is a potential agent that can be used for the treatment of peptic ulcers and gastric tissue wounds.
کلیدواژه‌ها
Ethanol؛ Hydroalcoholic extracts؛ Plantago major؛ Peptic ulcer
مراجع
  1. Chan F.K. Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage. European J. Gastroenterology and Hepatology. 2002;14(1):1-3.
  2. Ghahramani R., Sadoogh Abbasian A., Shafaee S. Prevelence of celiac disease in patients with different types of dyspepsia. J. Isfahan Medical School. 2009;27(93):65-73.
  3. Kalantari H., Nourian S.M. Prevalance of Peptic Ulcer Versus Non Ulcer Dyspepsia in Patients which were Admitted for Endoscopy. J. Isfahan Medical School. 2011;28(118).
  4. Yeomans N.D., Naesdal J. Systematic review: ulcer definition in NSAID ulcer prevention trials. Alimentary Pharmacology and Therapeutics. 2008;27(6):465-72.
  5. De M., Krishna De A., Banerjee A.B. Antimicrobial screening of some Indian spices. Phytotherapy Research: An Int. J. Devoted to Pharmacol. and Toxicological Evaluation of Natural Product Derivatives. 1999;13(7):616-8.
  6. Gilani A.H., Jabeen Q., Ghayur M.N., Janbaz KH., Akhtar M.S. Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract. J. Ethnopharmacology. 2005;98(1-2):127-35.
  7. Sharifa A.A., Neoh Y.L., Iswadi M.I., Khairul O., Abdul Halim M., Jamaludin M., Mohamed Azman A.B., Hing H.L. Effects of methanol, ethanol and aqueous extract of Plantago major on gram positive bacteria, gram negative bacteria and yeast. Ann Microsc. 2008;8:42-4.
  8. Wang H., Zhao C., Huang Y., Wang F., Li Y., Chung H.Y. Chemical constituents and bioactivities of plantaginis herba. Hong Kong Med J. 2015;22:29-35.
  9. Nemereshina O.N., Tinkov A.A., Gritsenko V.A., Nikonorov A.A. Influence of Plantaginaceae species on E. coli K12 growth in vitro: Possible relation to phytochemical properties. Pharmaceutical Biology. 2015;53(5):715-24.
  10. Gonçalves S., Romano A. The medicinal potential of plants from the genus Plantago (Plantaginaceae). Industrial Crops and Products. 2016;83:213-26.
  11. Akram M., Hamid A., Khalil A., Ghaffar A., Tayyaba N., Saeed A., Ali M., Naveed A. Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. International J. Immunopathology and Pharmacol. 2014;27(3):313-9.
  12. Kuhn M.A., Winston D. Herbal therapy and supplements: a scientific and traditional approach. Lippincott Williams and Wilkins; 2000.
  13. Bagheri S.M., Zare-Mohazabieh F., Momeni-Asl H., Yadegari M., Mirjalili A., Anvari M. Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats. Biomedical J. 2018;41(1):41-5.
  14. Ragheb E.M., Ibrahem E.S., Shalaby R.A. Potential Protective Effects of Plantago major Extracts against Indomethacin-Induced Gastric Ulcer in Rats. Egyptian J. Nutrition and Health. 2021;16(1):1-20.
  15. Farzaei F., Heydarpour F., Farzaei M.H., Haghighi Z.M., Abbasabadi Z., Sadeghi E. Protective Effect of Ferulago angulata (Schltdl.) Boiss. Hydroalcoholic Extract against Acetic Acid‑induced Colitis in Rat: Role of Pro‑inflammatory Cytokines. Pharmacognosy Res. 2018;10(4).
  16. Chandra S., Khan S., Avula B., Lata H., Yang M.H., ElSohly M.A., Khan I.A. Assessment of total phenolic and flavonoid content, antioxidant properties, and yield of aeroponically and conventionally grown leafy vegetables and fruit crops: A comparative study. Evidence-based Complementary and Alternative Medicine. 2014;2014.
  17. Dudonne S., Vitrac X., Coutiere P., Woillez M., Mérillon J.M. Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. J. Agric and Food Chemistry. 2009;57(5):1768-74.
  18. Benzie I.F., Strain J.J. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical Bbiochemistry. 1996;239(1):70-6.
  19. Memariani Z., Sharifzadeh M., Bozorgi M., Hajimahmoodi M., Farzaei M.H., Gholami M., Siavoshi F., Saniee P. Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: Role of α-pinene. J Traditional Chinese Medicine. 2017;37(1):57-63.
  20. Heeba GH., Hassan M.K., Amin R.S. Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. European J. Pharmacol. 2009;607(1-3):188-93.
  21. Tariq M., Khan H.A., Elfaki I., Arshaduddin M., Al Moutaery M., Al Rayes H., Al Swailam R. Gastric antisecretory and antiulcer effects of simvastatin in rats. J. Gastroenterology and Hepatology. 2007;22(12):2316-23.
  22. Sumbul S., Ahmad M.A., Mohd A., Mohd A. Role of phenolic compounds in peptic ulcer: An overview. J. Pharmacy and Bioallied Sci. 2011;3(3):361.
  23. Farzaei M.H., Khazaei M., Abbasabadei Z., Feyzmahdavi M., Mohseni G.R. Protective effect of tragopogon graminifolius DC against ethanol induced gastric ulcer. Iranian Red Crescent Medical J. 2013;15(9):813.
  24. Singh S., Khajuria A., Taneja S.C., Khajuria R.K., Singh J., Johri R.K., Qazi G.N. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine. 2008;15(6-7):408-15.
  25. Nabavizadeh F., Alizadeh A.M., Adeli S., Golestan M., Moloudian H., Kamalinejad M. Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer. Afr J. Pharm Pharmacol. 2011;5(2):155-9.
  26. He L.Z., Zhang Q., Wang S.C. Clinical study on treatment of gastric ulcer with qingwei zhitong pill. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi= Chinese J. Integrated Traditional and Western Medicine. 2001;21(6):422-3.
  27. Awuchi C.G., Saha P., Amle V.S., Nyarko R.O., Kumar R., Boateng E.A., Kahwa I., Boateng P.O., Asum C. A Study of Various Medicinal Plants used in Ulcer Treatment: A Review. J. Res in Applied Sci and Biotech. 2023;2(1):234-46.
  28. Wang CH., Wang Y.H., Zhou Y. Clinical and experimental study on effect of Chinese herbal drugs on producing prostaglandin in gastric mucosa. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi= Chinese J. Integrated Traditional and Western Medicine. 1994;14(9):528-30.
  29. García‐González M.A., Bujanda L., Quintero E., Santolaria S., Benito R., Strunk M., Sopeña F., Thomson C., Pérez‐Aisa A, Nicolás‐Pérez D., Hijona E. Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. International J. cancer. 2015;137(6):1362-73.
  30. Sostres C., Carrera-Lasfuentes P., Benito R., Roncales P., Arruebo M., Arroyo M.T., Bujanda L., García-Rodríguez L.A., Lanas A. Peptic ulcer bleeding risk. The role of Helicobacter pylori infection in NSAID/low-dose aspirin users. Official J. the American College of Gastroenterology| ACG. 2015;110(5):684-9.
  31. Baghizadeh A., Davati A., Heidarloo A.J., Emadi F., Aliasl J. Efficacy of Plantago major seed in management of ulcerative colitis symptoms: A randomized, placebo controlled, clinical trial. Complementary Therapies in Clinical Practice. 2021;44:101444.
  32. Albahri G., Badran A., Hijazi A., Daou A., Baydoun E., Nasser M., Merah O. The therapeutic wound healing bioactivities of various medicinal plants. Life. 2023;13(2):317.
  33. Nazarizadeh A., Mikaili P., Moloudizargari M., Aghajanshakeri S., Javaherypour S. Therapeutic uses and pharmacological properties of Plantago major L. and its active constituents. J. Basic Appl Sci Res. 2013;3(9):212-21.
  34. Paseban M., Mousavi Fayzabadi V., Tayyebi Meibodi N., Yousefi M., Hosseini A., Rakhshandeh H. The effect of hydro-alcoholic extract of Plantago major on indomethacin-induced gastric ulcer in rats. Internal Medicine Today. 2019;10:25(1):16-21.
  35. Hussan F., Mansor A.S., Hassan S.N., Kamaruddin T.N., Tasnim T.N., Budin S.B., Othman F. Anti-inflammatory property of Plantago major leaf extract reduces the inflammatory reaction in experimental acetaminophen-induced liver injury. Evidence-Based Complementary and Alternative Medicine. 2015;1:2015.
آمار
تعداد مشاهده مقاله: 271
تعداد دریافت فایل اصل مقاله: 267


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب