اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,829
تعداد مقالات32,098
تعداد مشاهده مقاله40,862,929
تعداد دریافت فایل اصل مقاله18,112,541
Nilkpoor, Maryam, Kargar Jahromi, Hossein, Johari, Mahboobeh, Nilkpoor, Mahdi, Rahdar, Hojjat. (1403). Effect of Nettle (Urtica dioica L.) Leaf Hydroalcoholic Extract on Atherosclerosis Plaque Formation of Cardiovascular Diseases. سامانه مدیریت نشریات علمی, 13(3), 653-660. doi: 10.22034/jmpb.2023.362785.1580
Maryam Nilkpoor; Hossein Kargar Jahromi; Mahboobeh Johari; Mahdi Nilkpoor; Hojjat Rahdar. "Effect of Nettle (Urtica dioica L.) Leaf Hydroalcoholic Extract on Atherosclerosis Plaque Formation of Cardiovascular Diseases". سامانه مدیریت نشریات علمی, 13, 3, 1403, 653-660. doi: 10.22034/jmpb.2023.362785.1580
Nilkpoor, Maryam, Kargar Jahromi, Hossein, Johari, Mahboobeh, Nilkpoor, Mahdi, Rahdar, Hojjat. (1403). 'Effect of Nettle (Urtica dioica L.) Leaf Hydroalcoholic Extract on Atherosclerosis Plaque Formation of Cardiovascular Diseases', سامانه مدیریت نشریات علمی, 13(3), pp. 653-660. doi: 10.22034/jmpb.2023.362785.1580
Nilkpoor, Maryam, Kargar Jahromi, Hossein, Johari, Mahboobeh, Nilkpoor, Mahdi, Rahdar, Hojjat. Effect of Nettle (Urtica dioica L.) Leaf Hydroalcoholic Extract on Atherosclerosis Plaque Formation of Cardiovascular Diseases. سامانه مدیریت نشریات علمی, 1403; 13(3): 653-660. doi: 10.22034/jmpb.2023.362785.1580

Effect of Nettle (Urtica dioica L.) Leaf Hydroalcoholic Extract on Atherosclerosis Plaque Formation of Cardiovascular Diseases

Journal of Medicinal plants and By-Products
مقاله 21، دوره 13، شماره 3، آذر 2024، صفحه 653-660    اصل مقاله (662.49 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.362785.1580
نویسندگان
Maryam Nilkpoor* 1؛ Hossein Kargar Jahromi2؛ Mahboobeh Johari3؛ Mahdi Nilkpoor4؛ Hojjat Rahdar5
1General physician, Medical College, Shiraz University of Medical Science, Shiraz, Iran
2Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
3M.A., Faculty of Humanities, Fasa Branch, Islamic Azad University, Fasa, Iran
4General physician, Department of Medicine, Hormozgan University of Medical Science, Bandar Abbas, Iran
5Doctor of dental medicine, Manila Central University, Manila, Philippines
چکیده
High levels of circulating fat are considered an important factor in atherosclerosis. So the most important object of the present study is to investigate the effect of nettle leaf extract mixture on atherosclerosis plaque formation and biochemical factors of cardiovascular diseases. Twenty-eight rabbits were randomly divided into four groups, normal diet as the control group, sunflower oil as a sham group, high cholesterolemic group (1% cholesterol), and high-cholesterol + nettle leaf extract (500 mg/kg of BW) group. Components were given to the sham and all 2 experimental groups as gavage. Obtained results of the present study indicated that body weight was reduced significantly in group III compared with the control groups and group II. In the slices prepared from the aorta of the 1% cholesterol-treated group, athreptic plaques were detectable. The plaques were formed of lipid-laden macrophages, and foam cells, with smooth muscle cells within the plaques. The thickness of the plaque increased so that it was more than half of the thickness of the environment. Pathology results showed that the nettle extract reduced significantly the damage in the arterial wall compared with the high-cholesterol group. The atheroma was fully raised and observable in the inner surface of the vessel (P<0/01). The results indicated that Grande ortie extract is efficient and tended to improve atherosclerosis complications in hypercholesterolemia rabbits.
کلیدواژه‌ها
Atherosclerosis؛ Nettle leaf؛ Hypercholesterolemia
مراجع
  1. Cersosimo E., DeFronzo R.A. Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases. Diabetes/Metabolism Res. and Reviews. 2006; 22(6):423-436.
  2. Nelson R.H. Hyperlipidemia as a risk factor for cardiovascular disease. Primary Care: Clinics in Office Practice. 2013; 40(1):195-211.
  3. Windler E. What is the consequence of an abnormal lipid profile in patients with type 2 diabetes or the metabolic syndrome?. Atherosclerosis Supplements. 2005; 6(3):11-4.
  4. Luboshitzky R., Aviv A., Herer P., Lavie L. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. 2002;12(5):421-5.
  5. Rafieian-Kopaei M., Setorki M., Doudi M., Baradaran A., Nasri H. Atherosclerosis: process, indicators, risk factors and new hopes. Int. J. Preventive Med. 2014; 5(8):927.
  6. Mironov A.A., Beznoussenko G.V. Opinion: On the way towards the new paradigm of atherosclerosis. Int. J. Molecular Sciences. 2022; 23(4):2152.
  7. Bhatnagar D, Soran H, Durrington P.N. Hypercholesterolaemia and its management. Bmj. 2008; 21:337.
  8. Lankin V.Z., Tikhaze A.K., Kukharchuk VV, Konovalova GG, Pisarenko OI, Kaminnyi AI, Shumaev KB, Belenkov YN. Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins. Biochem. of Diabetes and Atherosclerosis. 2003; 129-40.
  9. Talebi E., Haghighat Jahromi M., Khosravi Nezhad M., Rowghani E. Herbal plants as an appropriate stimulus with prophylactic potential in livestock: A review. Safe Future and Agricultural Research Journal (SFARJ). 2022; 1(1):11-9.
  10. Rasouli M., Kiasari A.M., Mokhberi V. The ratio of apoB/apoAI, apoB and lipoprotein (a) are the best predictors of stable coronary artery disease. Clinical Chemistry and Laboratory Medicine (CCLM). 2006; 44(8):1015-21.
  11. Heuer T., Gerards H., Pauw M., Gabbert H.E., Reis H.E. Toxic liver damage caused by HMG-CoA reductase inhibitor. Medizinische Klinik (Munich, Germany: 1983). 2000; 95(11):642-4.
  12. Yang Y., Xu J., Liu Z., Guo Q., Ye M., Wang G., Gao J., Wang J., Shu Z., Ge W., Liu Z. Progress in coal chemical technologies of China. Reviews in Chemical Engineering. 2019;36(1):21-66.
  13. Talebi E., Nasrollahi I., Bashardoost Z. Phytochemical compounds and bioactivity properties of the whole plant of maidenhair fern (Adiantum capillus-veneris L.) essential oil. Safe Future and Agricultural Research Journal (SFARJ). 2022; 30:1-0.
  14. Mehrabi Z., Firouzbakhsh F., Rahimi-Mianji G., Paknejad H. Immunity and growth improvement of rainbow trout (Oncorhynchus mykiss) fed dietary nettle (Urtica dioica) against experimental challenge with Saprolegnia parasitica. Fish & shellfish immunology. 2020;104:74-82.
  15. Emmelin N., Feldberg W. Distribution of acetylcholine and histamine in nettle plants. The New Phytologist. 1949; 48(2):143-8.
  16. Wagner H., Willer F., Samtleben R., Boos G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots. Phytomedicine. 1994;1(3):213-24.
  17. Golalipour M.J., Mohammad Gharravi A., Ghafari S., Azarhoush R. Protective Effect of URTICA DIOICA on renal morphometric and histologic alterations in streptozotocin diabetic Rats. Journal of Babol University of Medical Sciences. 2009;10(6):14-22.
  18. Qamar W., Sultana S. Polyphenols from Juglans regia L.(walnut) kernel modulate cigarette smoke extract induced acute inflammation, oxidative stress and lung injury in Wistar rats. Human & experimental toxicology. 2011; 30(6):499-506.
  19. Witztum J.L. Thematic reviews on the pathogenesis of atherosclerosis. Journal of Lipid Research. 2004; 45(6):991-2.
  20. Keaney Jr. JF. Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction. Molecular aspects of medicine. 2000;21(4-5):99-166.
  21. Farhadi Z., Khaksari M., Azizian H., Dabiri S. The brain neuropeptides and STAT3 mediate the inhibitory effect of 17-β Estradiol on central leptin resistance in young but not aged female high-fat diet mice. Metabolic Brain Disease. 2022;37(3):625-37.
  22. Prasad K., Lee P. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by aspirin. Journal of cardiovascular pharmacology and therapeutics. 2003;8(1):61-9.
  23. Lede V., Franke C., Meusel A., Teupser D., Ricken A., Thiery J., Schiller J., Huster D., Schöneberg T., Schulz A. Severe atherosclerosis and hypercholesterolemia in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. PloS one. 2016; 11(12):e0167888.
  24. Mix H., Widjaja A., Jandl O., Cornberg M., Kaul A., Göke M., Beil W., Kuske M., Brabant G., Manns MP., Wagner S. Expression of leptin and leptin receptor isoforms in the human stomach. Gut. 2000; 47(4):481-6.
  25. Janečková R. The role of leptin in human physiology and pathophysiology. Physiol Res. 2001; 50:443-59.
  26. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995; 269(5223):543-546.
  27. Zieba D.A., Biernat W., Barć J. Roles of leptin and resistin in metabolism, reproduction, and leptin resistance. Domestic animal endocrinology. 2020; 73:106472.
  28. Poetsch M.S., Strano A., Guan K. Role of leptin in cardiovascular diseases. Frontiers in endocrinology. 2020; 11:354.
  29. Pereira S., Cline D.L., Glavas M.M., Covey S.D., Kieffer T.J. Tissue-specific effects of leptin on glucose and lipid metabolism. Endocrine reviews. 2021;42(1):1-28.
  30. Nemati Z., Talebi E., Nasrollahi I., Khosravinezhad M. Physicochemical properties of Silybum marianum seed oil in two different regions of Iran. International Journal of New Technology and Research.2017; 3(2):37-40.
  31. Nasrollahi I., Talebi E., Nemati Z. Study on Silybum marianum seed through fatty acids comparison, peroxide tests, refractive index and oil percentage. Pharmacognosy Journal. 2016; 8(6): 595-597.
  32. Hertog M.G., Feskens E.J., Kromhout D., Hollman P.C., Katan M.B. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. The lancet. 1993; 342(8878):1007-1011.
  33. Cook N.C., Samman S. Flavonoids—chemistry, metabolism, cardioprotective effects, and dietary sources. The Journal of nutritional biochemistry. 1996; 7(2):66-76.
  34. Panche A.N., Diwan A.D., Chandra S.R. Flavonoids: an overview. Journal of nutritional science. 2016;5:e47.
  35. Lale N.E. A laboratory study of the comparative toxicity of products from three spices to the maize weevil. Postharvest Biology and Technology. 1992;2(1):61-64.
  36. Borradaile N.M., de Dreu L.E., Huff M.W. Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes. 2003; 52(10):2554-2561.
  37. Taleb A., Ahmad K.A., Ihsan A.U., Qu J., Lin N.A., Hezam K., Koju N., Hui L., Qilong D. Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases. Biomedicine & Pharmacotherapy. 2018; 102:689-698.
  38. Heitzer T., Ylä-Herttuala S., Luoma J., Kurz S., Münzel T., Just H., Olschewski M., Drexler H. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia: role of oxidized LDL. Circulation. 1996;93(7):1346-1353.
  39. Byers T., Perry G. Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annual review of Nutrition. 1992;12(1):139-159.
آمار
تعداد مشاهده مقاله: 198
تعداد دریافت فایل اصل مقاله: 156


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب