اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها3,016
تعداد مقالات33,714
تعداد مشاهده مقاله44,929,723
تعداد دریافت فایل اصل مقاله44,900,851
Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. (1402). Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection. سامانه مدیریت نشریات علمی, 79(1), 92-101. doi: 10.32592/ARI.2024.79.1.92
Sara Shahsavari; Mehdi Bakht; Hamid Sadeghi; Sara Rahimi; Farideh Movahed; Venus Chegini; Saeideh Gholamzadeh Khoei. "Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection". سامانه مدیریت نشریات علمی, 79, 1, 1402, 92-101. doi: 10.32592/ARI.2024.79.1.92
Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. (1402). 'Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection', سامانه مدیریت نشریات علمی, 79(1), pp. 92-101. doi: 10.32592/ARI.2024.79.1.92
Shahsavari, Sara, Bakht, Mehdi, Sadeghi, Hamid, Rahimi, Sara, Movahed, Farideh, Chegini, Venus, Gholamzadeh Khoei, Saeideh. Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection. سامانه مدیریت نشریات علمی, 1402; 79(1): 92-101. doi: 10.32592/ARI.2024.79.1.92

Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection

Archives of Razi Institute
مقاله 10، دوره 79، شماره 1، فروردین و اردیبهشت 2024، صفحه 92-101    اصل مقاله (335.96 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2024.79.1.92
نویسندگان
Sara Shahsavari1؛ Mehdi Bakht1؛ Hamid Sadeghi1؛ Sara Rahimi1؛ Farideh Movahed2؛ Venus Chegini2؛ Saeideh Gholamzadeh Khoei* 1، 2
1Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
2Clinical Research Development Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
چکیده
Background: Patients with diabetes mellitus (DM) frequently experience urinary tract infections. Many studies indicated that diabetes patients experience higher treatment costs, morbidity, and death due to UTI as a result of the spread of resistant bacterial strains in hospitals. In the current study, we looked at how glycemic control affects diabetic patients'''' rates of UTI, the pathogens that cause them, the presence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) organisms, and the infections'''' relation to diabetes.
Methods: Diabetes patients'''' midstream urine (MSU) samples were taken in a sterile, spotless, and dry wide-mouthed bottle. After following the standard methodology to collect and identify the organisms, disc diffusion antibiotic sensitivity tests were conducted. HbA1c measured for all patients. Using the SPSS 16.0 version, the data were examined.
Results: In the current study, 500 diabetic patients provided urine samples, after analyzing of urines it was revealed that189 (37.2%) of those individuals had UTI. Compared to 59 patients with managed glycemia, 130 individuals in the uncontrolled glycemic group experienced the most UTI cases. In both diabetic groups, females had a significantly higher prevalence of UTI than males (88.4% and 11.6%, respectively, 𝑃 < 0.004). 52.3% of women over 46 with uncontrolled glycemia experienced UTIs. The most common bacterial isolate, E. coli, displayed 58.4% MDR.
Conclusion: These findings demonstrate that, regardless of age or gender, glycemic control in diabetes patients is essential for decreasing UTI rates. It should be noted that, the best empirical treatment for diabetic patients with UTI should involve regular monitoring of the uropathogenic susceptibility patterns.
کلیدواژه‌ها
UTI؛ Diabetes mellitus؛ antibacterial resistance؛ glycemia
عنوان مقاله [English]
تاثیر دیابت بر پاتوژن های ادراری و مقاومت ضد میکروبی در بیماران مبتلا به عفونت ادراری
چکیده [English]
زمینه و هدف: بیماران مبتلا به دیابت ملیتوس اغلب دچار عفونت های مجاری ادراری می شوند. بیماران دیابتی در نتیجه گسترش سویه‌های باکتریایی مقاوم در بیمارستان‌ها، هزینه‌های درمانی وعوارض ناشی از UTI بالاتری را تجربه می‌کنند. در مطالعه حاضر، ما به چگونگی تأثیر کنترل قند خون بر میزان UTI در بیماران دیابتی، و همچنین پاتوژن هایی که آنها را ایجاد می کنند، وجود ارگانیسم های مقاوم به چند دارو و ارتباط عفونت ها با دیابت را بررسی کردیم.
روش‌ها: نمونه‌های ادرار میانی بیماران دیابتی در یک بطری دهان گشاد استریل جمع آوری کرده و طبق روش استاندارد برای جمع‌آوری و شناسایی ارگانیسم‌ها، آزمایش‌های حساسیت آنتی‌بیوتیکی انتشار دیسک انجام شد. HbA1c برای همه بیماران اندازه گیری شد. با استفاده از نسخه SPSS 16.0 داده ها مورد بررسی قرار گرفت.
یافته‌ها: 500 بیمار دیابتی نمونه ادرار خود را برای این مطالعه ارائه کردند که 189 نفر (2/37%) مبتلا به عفونت ادراری بودند. در مقایسه با 59 بیمار مبتلا به قند خون مدیریت شده، 130 نفر در گروه قند کنترل نشده بیشترین موارد UTI را تجربه کردند. در هر دو گروه دیابتی، زنان به طور قابل توجهی شیوع UTI بالاتری نسبت به مردان داشتند (به ترتیب 88.4% و 11.6%، ❑ < 0.004). 52.3 درصد از زنان بالای 46 سال مبتلا به قند خون کنترل نشده عفونت ادراری را تجربه کردند. شایع ترین ایزوله باکتری، E. coli، 58.4% MDR را نشان داد.
نتیجه‌گیری: این یافته‌ها نشان می‌دهد که بدون در نظر گرفتن سن یا جنسیت، کنترل قند خون در بیماران دیابتی برای کاهش میزان UTI ضروری است. بهترین درمان تجربی برای بیماران دیابتی مبتلا به UTI باید شامل نظارت منظم بر الگوهای حساسیت ادراری پاتوژن باشد.
کلیدواژه‌ها [English]
UTI, دیابت ملیتوس, مقاومت آنتی باکتریال, گلیسمی
سایر فایل های مرتبط با مقاله
مراجع
References
1. Kunin CM. Chemoprophylaxis and suppressive therapy in the
management of urinary tract infections. Journal of
Antimicrobial Chemotherapy. 1994;33(suppl_A):51-62.
2. Foxman B. Epidemiology of urinary tract infections:
Incidence, morbidity, and economic costs. Disease-a-Month.
2003;49(2):53-70.
3. Diagnosis and classification of diabetes mellitus. Diabetes
care. 2009;32 Suppl 1(Suppl 1):S62-7.
4. Abu-Ashour W, Twells L, Valcour J, Randell A, Donnan J,
Howse P, et al. The association between diabetes mellitus and
incident infections: a systematic review and meta-analysis of
observational studies. BMJ Open Diabetes Research and Care.
2017;5(1):e000336.
5. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes
atlas: global estimates of the prevalence of diabetes for 2011
and 2030. Diabetes research and clinical practice.
2011;94(3):311-21.
6. Cheraghi J, Zargushi M, Khyabani PK, Nasri S. Effects of
Parsley (Petroselinum Crispum) Hydroalcoholic Extract on
Spermatogenesis and Pituitary-Gonadal Axis in
Streptozotocin-Induced Diabetic Male Rat. Iranian Journal of
Veterinary Medicine. 2021;15(4).
7. Abdul-Sahib KY. Study of ciprofloxacin resistant Escherichia
coli (CREC) in type 2 diabetic patients with symptomatic
urinary tract infections. Iraqi J Comm Med. 2008;21:58-63.
8. Baqai R, Aziz M, Rasool G. Urinary tract infections in
diabetic patients and biofilm formation of uropathogens. Infect
Dis J Pak. 2008;17(1):21-4.
9. Yadav K, Prakash S, Serayi R, Shilpkar T, Shrestha S.
Antimicrobial susceptibility test of pathogens isolated from
urinary tract infection suspected cases. Janaki Medical College
Journal of Medical Science. 2014;2(1):28-34.
10. Geerlings SE, Stolk RP, Camps M, Netten PM, Collet TJ,
Hoepelman A, et al. Risk factors for symptomatic urinary tract
infection in women with diabetes. Diabetes care.
2000;23(12):1737-41.
11. Szucs S, Cserhati I, Csapo G, Balazs V. The relation
between diabetes mellitus and infections of the unirary tract. A
clinical, qualitative and quantitative bacteriological study
based upon 300 diabetics and 200 controls. The American
journal of the medical sciences. 1960;240:186-91.
12. Johnsson KM, Ptaszynska A, Schmitz B, Sugg J, Parikh SJ,
List JF. Urinary tract infections in patients with diabetes
treated with dapagliflozin. Journal of Diabetes and its
Complications. 2013;27(5):473-8.
13. Geerlings SE, Brouwer EC, Van Kessel KC, Gaastra W,
Stolk RP, Hoepelman AI. Cytokine secretion is impaired in
women with diabetes mellitus. European journal of clinical
investigation. 2000;30(11):995-1001.
14. Borj M, Taghizadehborojeni S, Shokati A, Sanikhani N,
Pourghadamyari H, Mohammadi A, et al. Urinary tract
infection among diabetic patients with regard to the risk
factors, causative organisms and their antimicrobial
susceptibility profiles at Firoozgar Hospital, Tehran, Iran.
International Journal of Life Science and Pharma Research.
2017;7(3):L38-L47.
15. Hamdan HZ, Kubbara E, Adam AM, Hassan OS, Suliman
SO, Adam I. Urinary tract infections and antimicrobial
sensitivity among diabetic patients at Khartoum, Sudan.
Annals of clinical microbiology and antimicrobials.
2015;14(1):1-6.
16. Goldstein FW. Antibiotic susceptibility of bacterial strains
isolated from patients with community-acquired urinary tract
infections in France. Multicentre Study Group. Eur J Clin
Microbiol Infect Dis. 2000;19(2):112-7.
17. Halaji M, Feizi A, Mirzaei A, Sedigh Ebrahim-Saraie H,
Fayyazi A, Ashraf A, et al. The Global Prevalence of Class 1
Integron and Associated Antibiotic Resistance in Escherichia
coli from Patients with Urinary Tract Infections, a Systematic
Review and Meta-Analysis. Microb Drug Resist.
2020;26(10):1208-18.
18. Bakht M, Alizadeh SA, Rahimi S, Kazemzadeh Anari R,
Rostamani M, Javadi A, et al. Phenotype and genetic
determination of resistance to common disinfectants among
biofilm-producing and non-producing Pseudomonas
aeruginosa strains from clinical specimens in Iran. BMC
microbiology. 2022;22(1):124.
19. Parte A, Krieg NR, Ludwig W, Whitman WB, Hedlund BP,
Paster BJ, et al. Bergey''''s Manual of Systematic Bacteriology:
Volume 4: The Bacteroidetes, Spirochaetes, Tenericutes
(Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria,
Dictyoglomi, Gemmatimonadetes, Lentisphaerae,
Verrucomicrobia, Chlamydiae, and Planctomycetes: Springer
Science & Business Media; 2011.
20. Patterson JE, Andriole VT. Bacterial urinary tract infections
in diabetes. Infect Dis Clin North Am. 1997;11(3):735-50.
21. Aswani SM, Chandrashekar U, Shivashankara K, Pruthvi B.
Clinical profile of urinary tract infections in diabetics and nondiabetics. Australas Med J. 2014;7(1):29-34.
22. Sewify M, Nair S, Warsame S, Murad M, Alhubail A,
Behbehani K, et al. Prevalence of Urinary Tract Infection and
Antimicrobial Susceptibility among Diabetic Patients with
Controlled and Uncontrolled Glycemia in Kuwait. J Diabetes
Res. 2016;2016:6573215.
23. Al Benwan K, Al Sweih N, Rotimi VO. Etiology and
antibiotic susceptibility patterns of community- and hospital-
108 Shahsavari et al / Archives of Razi Institute, Vol. 79, No. 1 (2024) 98-108
acquired urinary tract infections in a general hospital in
Kuwait. Med Princ Pract. 2010;19(6):440-6.
24. Nicolle LE. Urinary tract infections in special populations:
diabetes, renal transplant, HIV infection, and spinal cord
injury. Infect Dis Clin North Am. 2014;28(1):91-104.
25. Adeleye O, Ajala T, Adekoya OA, Adeleye AI. Effective
Dose Regimen of STZ for STZ-induced Diabetes in a Rat
Model. Iranian Journal of Veterinary Medicine. 2023.
26. Khani A, Khorasgani EM. Investigating the Effect of
Hydroalcoholic Extract of Eryngos on Plasma Concentration of
Blood Glucose, Blood Cells and Pancreatic Tissue in Diabetic
Rats. Iranian Journal of Veterinary Medicine. 2021;15(4).
27. Shahsavani M, Norouzi P, Kalalianmoghaddam H, Teimouri
M. Effects of Kudzu Root on Oxidative Stress and
Inflammation in Streptozotocin-Induced Diabetic Rats. Iranian
Journal of Veterinary Medicine. 2022.
28. Simkhada R. Urinary tract infection and antibiotic sensitivity
pattern among diabetics. Nepal Med Coll J. 2013;15(1):1-4.

آمار
تعداد مشاهده مقاله: 12,152
تعداد دریافت فایل اصل مقاله: 6,056


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب