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Evaluating the Antioxidant Effects of Onion (Allium cepa) on Blood Biochemical Factors and Antioxidants after Consuming Tartrazine in Rats | ||
| Archives of Razi Institute | ||
| مقاله 20، دوره 78، شماره 6، بهمن و اسفند 2023، صفحه 1836-1842 اصل مقاله (706.45 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.6.1836 | ||
| نویسندگان | ||
| A Zahedi* 1؛ A Saravy2؛ M Poorghasemi3 | ||
| 1Department of Veterinary Pathology, Faculty of Veterinary Medicine, Islamic Azad University, Rasht Branch, Rasht, Iran | ||
| 2Department of Internal Medicine, Guilan University of Medical Sciences, Rasht, Iran | ||
| 3Department of Animal Science, Faculty of Agriculture, Islamic Azad University, Rasht Branch, Rasht, Iran | ||
| چکیده | ||
| Colors have been adding to food naturally and artificially for centuries to make them attractive. According to the Food and Drug Organization, eight artificial colors were registered for the nutrition application, one of them is tartrazine, which is widely used in foods and cosmetics. Food colors cause a significant decrease in weight, an increase in proteins and liver enzymes, an increase in thyroid hormones, an increase in total cholesterol and triglyceride. Onion as an antioxidant can reduce the harmful effects of artificial food colors on weight gain, antioxidant activity and blood biochemical factors. This study aims to investigate the antioxidant properties of the onion on serum biochemical factors and antioxidants in Wistar rats after consuming tartrazine. Eighty Rats were divided into four groups,20 mice in each. The first group received water without additives and was considered to be the control, the second group received tartrazine, the third group received tartrazine with onion juice, and the fourth group received only onion juice through gastric gavage. This experiment was performed for 60 days, and then the antioxidant activities of SOD, CAT, GPX, and the biochemical parameters of HDL and LDL were measured. Tartrazine decreased the antioxidant activities of SOD, CAT, GPX, and the biochemical parameters of HDL and LDL. The results showed that the consumption of tartrazine causes the production of free radicals, which is the reason for the significant reduction of antioxidant activities and serum biochemical factors. Onion as an antioxidant in this study reduces the effects of tartrazine on antioxidant activities and serum biochemical factors. | ||
| کلیدواژه‌ها | ||
| Allium cepa؛ Antioxidant؛ Blood factors؛ Rat؛ Tartrazine | ||
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| مراجع | ||
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References 1. Sasaki YF, Kawaguchi S, Kamaya AM. The comet assay with 8 mouse organs: Results with 39 currently used food additives. Mutat Res. 2002;519:103-119. 2. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 2005;51(2):117-123. 3. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. J Urol. 1996;48:835-850. 4. Khaki A, Fathiazad F, Nouri M, Khaki AA, Khamenehi HJ, Hamadeh M. Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat. Folia Morphol. 2009;68(1):45-51. 5. Thomas MJ. The role of free radicals antioxidants. Nutr. 2000;16(7):716-727. 6. Rowe KS, Rowe KJ. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. J Pediatr. 1994;125(5):691-698. 7. Velioglu YS, Mazza G, Gao L, Oomah BD. Antioxidant activity and total phenolics in selected fruits, vegetables and grain products. J Agric Food Chem. 1998;46(10):113-117. 8. Himri I, Bellachen S, Souna F, Belmekki F, Aziz M, Bnouham M, Aziz K. A 90-day oral toxicity study of tartrazine, a synthetic food dye, in wistar rats. Int J Pharm Pharm. Sci. 2011;3(3):159-69. 9. Gautam D, Sharma G, Goyal RP. Evaluation of toxic impact of tartrazine on male Swiss Albino Mice. Pharmacol. 2010;1:133-140. 10. Khasanah H, Fanata WID, Kusbianto DE. Analysis of chicken gut microbiome fed by Phyllanthus urinaria as phytobiotic using 16S rRNA metagenome. Iranian J Appl Anim Sci. 2022;12(1):151-160. 11.Boots AW, Haenen GRMM, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European J Pharmacol. 2008;585:337-325. 12. Nikbakht SA, Mohammadabadi T, Mirzadeh K. The effect of feeding Tribulus terrestris plant powder on growth performance, digestibility, rumen and blood parameters of Iranian Arabic lambs. Iranian J Appl Anim Sci. 2021;11(4):781-788. 13. Hossein Abadi M, Ghoorchi T, Amirteymouri E, Poorghasemi M. The effect of different processing methods of linseed on growth performance, nutrient digestibility, blood parameters and ruminate behavior of lambs. Vet Med Sci. 2023;2023:1-10. 14. Kikelomo OM, Stephen MS, Michael AF, Udoka EO, Toyin YF. Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Food Chem Toxicol. 2008;46(12):604-611. 15.Calomme M, Pieters L, Vlietinck A, Vanden Berghe D. Inhibition of bacterial mutagenesis by citrus flavonoids. Planta Med. 1996;62(3):222-226. 16. Park J, Kim J, Kim MK. Onion flesh and onion peel enhance antioxidant status in aged rats. J Nutr Sci Vitaminol. 2007;53(1):21-29. 17. Sharma G, Gautam D, Goyal RP. Tartrazine induced haematological and serological changes in female swiss albino mice, Musmusculus. Pharmacol. 2009;3:774-788 | ||
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