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Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. (1402). Creatine Activity as a Neuromodulator in the Central Nervous System. سامانه مدیریت نشریات علمی, 78(4), 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
G. H Meftahi; B Hatef; G Pirzad Jahromi. "Creatine Activity as a Neuromodulator in the Central Nervous System". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. (1402). 'Creatine Activity as a Neuromodulator in the Central Nervous System', سامانه مدیریت نشریات علمی, 78(4), pp. 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. Creatine Activity as a Neuromodulator in the Central Nervous System. سامانه مدیریت نشریات علمی, 1402; 78(4): 1169-1175. doi: 10.32592/ARI.2023.78.4.1169

Creatine Activity as a Neuromodulator in the Central Nervous System

Archives of Razi Institute
مقاله 2، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1169-1175    اصل مقاله (258.96 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1169
نویسندگان
G. H Meftahi* ؛ B Hatef؛ G Pirzad Jahromi
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and acts as a neuromodulator. Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies have reported that brain creatine content could be enhanced with creatine supplementation. Nevertheless, there is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective effects of creatine on various mental aspects, such as cognition, memory skills, and spatial memory. The present review aimed to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, first, creatine and its potential influence on cognitive health and performance were briefly reviewed. Next, the existing experimental and clinical evidence was specifically explored to understand how creatine could interact as a neurotransmitter in the nervous system. Studies have revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with the N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies that creatine can be considered a neuromodulator.
کلیدواژه‌ها
Creatine, GABA, Neuroprotection, Neurotransmitter Agents؛ N-Methyl-D-Aspartate
عنوان مقاله [English]
Creatine acts as a neuromodulator in the central nervous system
چکیده [English]
Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence demonstrates that creatine similar to neurotransmitters released in an excitotoxic, action-potential dependent manner and acts as a neuromodulator.
Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies reported that brain creatine content could be enhanced with creatine supplementation. There is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective properties of creatine in various mental aspects such as cognition, memory skills, and spatial memory. In the present review, we are going to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, we first briefly review creatine and its potential influence on cognitive health and performance. Next, we specifically explore existing experimental and clinical evidence to understand how creatine could interact as a neurotransmitter in the nervous system. Studies revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with N-methyl-D-aspartate receptor (NMDAR), Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A (5-HT1A) receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies creatine can be considered as a neuromodulator.
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