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Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. (1402). Creatine Activity as a Neuromodulator in the Central Nervous System. سامانه مدیریت نشریات علمی, 78(4), 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
G. H Meftahi; B Hatef; G Pirzad Jahromi. "Creatine Activity as a Neuromodulator in the Central Nervous System". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. (1402). 'Creatine Activity as a Neuromodulator in the Central Nervous System', سامانه مدیریت نشریات علمی, 78(4), pp. 1169-1175. doi: 10.32592/ARI.2023.78.4.1169
Meftahi, G. H, Hatef, B, Pirzad Jahromi, G. Creatine Activity as a Neuromodulator in the Central Nervous System. سامانه مدیریت نشریات علمی, 1402; 78(4): 1169-1175. doi: 10.32592/ARI.2023.78.4.1169

Creatine Activity as a Neuromodulator in the Central Nervous System

Archives of Razi Institute
مقاله 2، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1169-1175    اصل مقاله (258.96 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1169
نویسندگان
G. H Meftahi* ؛ B Hatef؛ G Pirzad Jahromi
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and acts as a neuromodulator. Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies have reported that brain creatine content could be enhanced with creatine supplementation. Nevertheless, there is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective effects of creatine on various mental aspects, such as cognition, memory skills, and spatial memory. The present review aimed to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, first, creatine and its potential influence on cognitive health and performance were briefly reviewed. Next, the existing experimental and clinical evidence was specifically explored to understand how creatine could interact as a neurotransmitter in the nervous system. Studies have revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with the N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies that creatine can be considered a neuromodulator.
کلیدواژه‌ها
Creatine, GABA, Neuroprotection, Neurotransmitter Agents؛ N-Methyl-D-Aspartate
عنوان مقاله [English]
Creatine acts as a neuromodulator in the central nervous system
چکیده [English]
Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence demonstrates that creatine similar to neurotransmitters released in an excitotoxic, action-potential dependent manner and acts as a neuromodulator.
Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies reported that brain creatine content could be enhanced with creatine supplementation. There is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective properties of creatine in various mental aspects such as cognition, memory skills, and spatial memory. In the present review, we are going to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, we first briefly review creatine and its potential influence on cognitive health and performance. Next, we specifically explore existing experimental and clinical evidence to understand how creatine could interact as a neurotransmitter in the nervous system. Studies revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with N-methyl-D-aspartate receptor (NMDAR), Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A (5-HT1A) receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies creatine can be considered as a neuromodulator.
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مراجع
  1. Szot M, Karpecka-Galka E, Drozdz R, Fraczek B. Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports? Healthcare (Basel). 2022;10(2).
  2. Bahai Z, Jangravi Z, Hatef B, Valipour H, Meftahi G. Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress. Behav Pharmacol. 2023; In Press.
  3. Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018;108:166-73.
  4. Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, et al. Effects of Creatine Supplementation on Brain Function and Health. Nutrients. 2022;14(5).
  5. Rambo LM, Ribeiro LR, Schramm VG, Berch AM, Stamm DN, Della-Pace ID, et al. Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. Brain Res Bull. 2012;88(6):553-9.
  6. Rae CD, Broer S. Creatine as a booster for human brain function. How might it work? Neurochem Int. 2015;89:249-59.
  7. Andersen JV, Markussen KH, Jakobsen E, Schousboe A, Waagepetersen HS, Rosenberg PA, et al. Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration. Neuropharmacology. 2021;196:108719.
  8. Heidary N, Sahraei H, Afarinesh MR, Bahari Z, Meftahi GH. Investigating the inhibition of NMDA glutamate receptors in the basolateral nucleus of the amygdala on the pain and inflammation induced by formalin in male Wistar rats. Front Biol. 2018;13:149-55.
  9. Al-Nasser MN, Mellor IR, Carter WG. Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. Brain Sci. 2022;12(5).
  10. Cunha MP, Lieberknecht V, Ramos-Hryb AB, Olescowicz G, Ludka FK, Tasca CI, et al. Creatine affords protection against glutamate-induced nitrosative and oxidative stress. Neurochem Int. 2016;95:4-14.
  11. Kostadinova I, Kondeva-Burdina M, Marinov L, Vezenkov LL, Simeonova R. Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson's Disease. Life (Basel). 2023;13(1).
  12. Cunha MP, Pazini FL, Ludka FK, Rosa JM, Oliveira A, Budni J, et al. The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test. Amino Acids. 2015;47(4):795-811.
  13. Andreassen OA, Jenkins BG, Dedeoglu A, Ferrante KL, Bogdanov MB, Kaddurah-Daouk R, et al. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J Neurochem. 2001;77(2):383-90.
  14. Genius J, Geiger J, Bender A, Moller HJ, Klopstock T, Rujescu D. Creatine protects against excitoxicity in an in vitro model of neurodegeneration. PLoS One. 2012;7(2):e30554.
  15. Juravleva E, Barbakadze T, Mikeladze D, Kekelidze T. Creatine enhances survival of glutamate-treated neuronal/glial cells, modulates Ras/NF-kappaB signaling, and increases the generation of reactive oxygen species. J Neurosci Res. 2005;79(1-2):224-30.
  16. Jamme I, Petit E, Divoux D, Gerbi A, Maixent JM, Nouvelot A. Modulation of mouse cerebral Na+,K(+)-ATPase activity by oxygen free radicals. Neuroreport. 1995;7(1):333-7.
  17. Lees GJ, Lehmann A, Sandberg M, Hamberger A. The neurotoxicity of ouabain, a sodium-potassium ATPase inhibitor, in the rat hippocampus. Neurosci Lett. 1990;120(2):159-62.
  18. Royes LF, Fighera MR, Furian AF, Oliveira MS, Fiorenza NG, Ferreira J, et al. Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: role of NMDA receptors. Neurochem Int. 2008;53(1-2):33-7.
  19. Bertuccio CA, Cheng SX, Arrizurieta EE, Martin RS, Ibarra FR. Mechanisms of Na+-K+-ATPase phosphorylation by PKC in the medullary thick ascending limb of Henle in the rat. Pflugers Arch. 2003;447(1):87-96.
  20. Burjanadze G, Shengelia M, Dachanidze N, Mikadze M, Menabde K, Koshoridze N. Creatine–facilitated protection of stress caused by disrupted circadian rhythm. Biol Rhythm Res. 2018;49(1):61-75.
  21. Allen PJ, D'Anci KE, Kanarek RB, Renshaw PF. Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats. Pharmacol Biochem Behav. 2012;101(4):588-601.
  22. Souza MA, Magni DV, Guerra GP, Oliveira MS, Furian AF, Pereira L, et al. Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine. Amino Acids. 2012;43(6):2491-503.
  23. Obata K. Synaptic inhibition and gamma-aminobutyric acid in the mammalian central nervous system. Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(4):139-56.
  24. Almeida LS, Salomons GS, Hogenboom F, Jakobs C, Schoffelmeer AN. Exocytotic release of creatine in rat brain. Synapse. 2006;60(2):118-23.
  25. Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, et al. Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism. Neurobiol Dis. 2002;11(2):298-307.
  26. Huusko N, Romer C, Ndode-Ekane XE, Lukasiuk K, Pitkanen A. Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy. Brain Struct Funct. 2015;220(1):153-91.
  27. Hunt RF, Boychuk JA, Smith BN. Neural circuit mechanisms of post-traumatic epilepsy. Front Cell Neurosci. 2013;7:89.
  28. Gerbatin RR, Silva LFA, Hoffmann MS, Della-Pace ID, do Nascimento PS, Kegler A, et al. Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2019;92:328-38.
  29. Koga Y, Takahashi H, Oikawa D, Tachibana T, Denbow DM, Furuse M. Brain creatine functions to attenuate acute stress responses through GABAnergic system in chicks. Neuroscience. 2005;132(1):65-71.
  30. Nersesova LS, Petrosyan MS, Arutjunyan AV. Neuroprotective Potential of Creatine. Hidden Resources of Its Therapeutic and Preventive Use. Neurochem J. 2022;16(1):14-30.
  31. Ducray AD, Schlappi JA, Qualls R, Andres RH, Seiler RW, Schlattner U, et al. Creatine treatment promotes differentiation of GABA-ergic neuronal precursors in cultured fetal rat spinal cord. J Neurosci Res. 2007;85(9):1863-75.
  32. Allen PJ, D'Anci KE, Kanarek RB, Renshaw PF. Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner. Neuropsychopharmacology. 2010;35(2):534-46.
  33. Cunha MP, Pazini FL, Oliveira A, Bettio LE, Rosa JM, Machado DG, et al. The activation of alpha1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2013;44:39-50.
  34. Andres RH, Huber AW, Schlattner U, Perez-Bouza A, Krebs SH, Seiler RW, et al. Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue. Neuroscience. 2005;133(3):701-13.
  35. Cunha MP, Pazini FL, Oliveira A, Machado DG, Rodrigues AL. Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice. Brain Res Bull. 2013;95:61-9.
  36. Kanekar S, Ettaro R, Hoffman MD, Ombach HJ, Brown J, Lynch C, et al. Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression. Int J Mol Sci. 2021;22(15).
  37. Lee JY, Martin-Bastida A, Murueta-Goyena A, Gabilondo I, Cuenca N, Piccini P, et al. Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease. Nat Rev Neurol. 2022;18(4):203-20.
  38. Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology. 2006;67(7):1262-4.
  39. Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, et al. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. J Neurochem. 2009;109(5):1427-39.
  40. Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, et al. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol. 1999;157(1):142-9.
  41. McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006;185(1):93-103.
  42. Cunha MP, Machado DG, Capra JC, Jacinto J, Bettio LE, Rodrigues AL. Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012;26(11):1489-501.
  43. Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress (Thousand Oaks). 2021;5:24705470211029254.
  44. Hadipour M, Refahi S, Jangravi Z, Meftahi GH. Tarooneh extract relieves anxiety-like behaviors and cognitive deficits by inhibiting synaptic loss in the hippocampus and frontal cortex in rats subjected to chronic restraint stress. 3 Biotech. 2023;13(5):156.
  45. Nasrin F, Shiravi A, Bahari Z, Shirvani H, Meftahi GH. Basolateral Amygdala α1-Adrenergic Receptor Suppression Attenuates Stress-Induced Anxiety-Like Behavior and Spine Morphology Impairment on Hippocampal CA1 Pyramidal Neurons. Neurochemical Journal. 2020;14(1):77-89.
  46. Shareghi Brojeni M, Korani M, Meftahi GH, Davoodian N, Hadipour M, Jahromi GP. Laterality dissociation of ventral hippocampus inhibition in learning and memory, glial activation and neural arborization in response to chronic stress in male Wistar rats. J Chem Neuroanat. 2022;121:102090.
  47. Chukwu OO, Emelike CU, Konyefom NG, Ibekailo SN, Ekakitie OO, Ghasi S, et al. Histological Studies of the Heart and Biochemical Changes Due to the Perinatal Consumption of Hibiscus sabdariffa (Flavonoid-rich Extract) to Feed-restricted Rats on Offspring. Iran J Vet Med. 2023;17(1):37-46.
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  2. Mahdavi K, Zendehdel M, Baghbanzadeh A. Central effects of opioidergic system on food intake in birds and mammals: a review. Vet Res Commun. 2023.
  3. Nikjooy N, Asghari A, Hassanpour S, Arfaee F. Study of Anti-nociceptive Role of the Manna of Hedysarum and the Neurotransmitter Systems Involved in Mice. Iran J Vet Med. 2022;16(3):265-73.
  4. Rezaei S, Asghari A, Hassanpour S, Arfaei F. Anti-nociceptive Mechanisms of Testosterone in Unilateral Sciatic Nerve Ligated Male Rat. Iran J Vet Med. 2022;16(1):36-45.
  5. Shojaei M, Yousefi A, Zendehdel M, Khodadadi M. Food Intake Regulation in Birds: the Role of Neurotransmitters and Hormones. Iran J Vet Med. 2020;14(1):99-115.
  6. Moon RT, Kohn AD, De Ferrari GV, Kaykas A. WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet. 2004;5(9):691-701.
  7. Nusse R. Wnt signaling in disease and in development. Cell Res. 2005;15(1):28-32.
  8. Liu E, Xie AJ, Zhou Q, Li M, Zhang S, Li S, et al. GSK-3beta deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory. Sci Rep. 2017;7(1):5781.
  9. Leem YH, Kato M, Chang H. Regular exercise and creatine supplementation prevent chronic mild stress-induced decrease in hippocampal neurogenesis via Wnt/GSK3beta/beta-catenin pathway. J Exerc Nutrition Biochem. 2018;22(2):1-6.
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