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Synthesis of Remdesivir Derivate as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions | ||
| Archives of Razi Institute | ||
| مقاله 11، دوره 78، شماره 6، بهمن و اسفند 2023، صفحه 1753-1761 اصل مقاله (746.81 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.6.1753 | ||
| نویسندگان | ||
| R Sumardi* 1؛ Y Rifai2؛ G Alam2 | ||
| 1Faculty of Pharmacy, Hasanuddin University, makassar, Indonesia | ||
| 2Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia | ||
| چکیده | ||
| Remdesivir, a competitive inhibitor of viral RNA-dependent RNA polymerase, is the drug of choice for anti-COVID-19 treatment. However, the instability of these substances in plasma raises doubts about their therapeutic potency. Additionally, SARS-CoV-2-infected cells may exhibit a variety of antiviral behaviors due to intricate activation pathways. Therefore, this study aimed to develop a synthesis for the remdesivir derivative. The remdesivir derivative was synthesized using acetyl chloride as a reagent in a ratio of 1:3 in dichloromethane and tetrahydrofuran solvent at 30°C for 6 h. Thin-layer chromatography and spectrophotometers (1H NMR and 13C NMR) were used to identify the produced molecule, which was a brownish-yellow crystalline powder. The results of the synthesis yielded 0.8 gr (77.34%), and the Rf value of the remdesivir derivate was 0.54. The characterization with 1H NMR at δ2.5 ppm (3H, s) indicated the presence of a proton in the H-C-C=O structure caused by the substitution of the acetyl group in the remdesivir structure. The 13C NMR data indicated the presence of aromatic carbons, alkenes, C≡N, and carbon bonds with electronegative O. This remdesivir derivate chemical can be a potential candidate for an anti-COVID-19 drug that has more potency because it has substitutions of acetyl groups at positions 2' and 3' in the structure of remdesivir. | ||
| کلیدواژه‌ها | ||
| Acetylation؛ Acetyl chloride؛ COVID-19؛ Remdesivir؛ Remdesivir derivate؛ Synthesis | ||
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