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Mupirocin Niosomal Gel with Bee Honey & Curcumin as Nano-Drug Delivery in Wound Healing Applications | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 اردیبهشت 1402 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2023.362206.2732 | ||
| نویسندگان | ||
| S Theerdhala* 1، 2؛ N Harikrishnan3 | ||
| 1Research Scholar, Department of Pharmaceutics, Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute, Deemed to be University, Velappanchavadi, Chennai - 600077, Tamil Nadu, India | ||
| 2Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore (Dt.) - 524346, Andhra Pradesh, India | ||
| 3Department of Pharmaceutical Analysis, Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Deemed to be University, Velappanchavadi, Chennai - 600077, Tamil Nadu, India | ||
| چکیده | ||
| Wound healing research is still aiming toward complete regeneration and restoration of the skin's function and structure with the least amount of scarring. The nano wound healing strategy produces a superior drug delivery method, which can promote faster wound healing. In this current research niosomal gel has been developed to reduce toxicity while increasing accumulation at the target site. The wound healing potential activity of Mupirocin-loaded niosomal gel formulated with honey and curcumin, as well as their blends, by ether injection method and investigated for further studies. FTIR and DSC studies confirmed the compatibility between the drug and excipients. The entrapment efficiency and drug content of the niosomal gel were found to be satisfactory. The pH, viscosity, and spreadability of the niosomal gel were within the acceptable range, indicating that the formulation is suitable for the topical application shown in Table-1. SEM analysis revealed that the niosomes were spherical, uniform in size, and suitable for drug delivery systems. In vitro, diffusion studies confirm Formulation F7 has prolonged drug delivery to the wound site, 100% drug release at 14 h. Stability studies demonstrated that the niosomal gel is physically and chemically stable. This study could be a safe and novel approach for an effective drug delivery system for an excision wound model in albino rats and compare it to Mupicip a commercially available ointment. Formulation F7 has shown a higher percentage of wound contraction 99.08% and promotes faster wound healing confirmed by histopathological study. | ||
| کلیدواژه‌ها | ||
| Wound healing؛ Mupirocin؛ Curcumin؛ Honey؛ Niosomal ointment Nano-drug delivery | ||
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آمار تعداد مشاهده مقاله: 24 |
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