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Kodori, M, Amani, J, Meshkat, Z, Ahmadi, A. (1402). Coxiella burnetii Pathogenesis: Emphasizing the Role of the Autophagic Pathway. سامانه مدیریت نشریات علمی, 78(3), 785-796. doi: 10.22092/ari.2023.361161.2636
M Kodori; J Amani; Z Meshkat; A Ahmadi. "Coxiella burnetii Pathogenesis: Emphasizing the Role of the Autophagic Pathway". سامانه مدیریت نشریات علمی, 78, 3, 1402, 785-796. doi: 10.22092/ari.2023.361161.2636
Kodori, M, Amani, J, Meshkat, Z, Ahmadi, A. (1402). 'Coxiella burnetii Pathogenesis: Emphasizing the Role of the Autophagic Pathway', سامانه مدیریت نشریات علمی, 78(3), pp. 785-796. doi: 10.22092/ari.2023.361161.2636
Kodori, M, Amani, J, Meshkat, Z, Ahmadi, A. Coxiella burnetii Pathogenesis: Emphasizing the Role of the Autophagic Pathway. سامانه مدیریت نشریات علمی, 1402; 78(3): 785-796. doi: 10.22092/ari.2023.361161.2636

Coxiella burnetii Pathogenesis: Emphasizing the Role of the Autophagic Pathway

Archives of Razi Institute
مقاله 3، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 785-796    اصل مقاله (654.5 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2023.361161.2636
نویسندگان
M Kodori1، 2؛ J Amani3؛ Z Meshkat4؛ A Ahmadi* 1
1Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University, of Medical Sciences, Tehran, Iran
2Non Communicable Diseases Research Center, Bam University of Medical Sciences, Bam, the Islamic Republic of Iran
3Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University, of Medical Sciences, Tehran, Iran
4Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Coxiella burnetii (C. burnetii), the etiological agent of the Q fever disease, ranks among the most sporadic and persistent global public health concerns. Ruminants are the principal source of human infections and diseases present in both acute and chronic forms. This bacterium is an intracellular pathogen that can survive and reproduce under acidic (pH 4 to 5) and harsh circumstances that contain Coxiella-containing vacuoles. By undermining the autophagy defense system of the host cell, C. burnetii is able to take advantage of the autophagy pathway, which allows it to improve the movement of nutrients and the membrane, thereby extending the vacuole of the reproducing bacteria. For this method to work, it requires the participation of many bacterial effector proteins. In addition, the precise and prompt identification of the causative agent of an acute disease has the potential to delay the onset of its chronic form. Moreover, to make accurate and rapid diagnoses, it is necessary to create diagnostic devices. This review summarizes the most recent research on the epidemiology, pathogenesis, and diagnosis approaches of C. burnetii. This study also explored the complicated relationships between C. burnetii and the autophagic pathway, which are essential for intracellular reproduction and survival in host cells for the infection to be effective.
کلیدواژه‌ها
Autophagy pathway؛ Coxiella burnetii؛ Coxiella-containing vacuoles؛ Epidemiology؛ Intracellular replication؛ Pathogenesis؛ Q fever
عنوان مقاله [English]
بیماری زایی کوکسیلا بورنتی: تاکید بر نقش مسیر اتوفاژیک در عفونت زایی
چکیده [English]
کوکسیلا بورنتی، عامل ایجاد کننده بیماری تب کیو، یکی از عوامل اسپورادیک و نگرانی های مهم بهداشت عمومی در جهان می باشد. نشخوارکنندگان منبع و منشاء اصلی عفونت های انسانی تب کیو می بشند که به دو شکل حاد و مزمن تظاهر پیدا می کندد. کوکسیلا بورنتی یک پاتوژن درون سلولی اجباری است که می تواند در شرایط اسیدی (PH 4 تا 5) و شرایط سخت نامساعد سلول میزبان از جمله واکوئل های حاوی کوکسیلا (CCVs) زنده بماند و تولید مثل کند. این باکتری با تضعیف سیستم دفاعی اتوفاژی سلول میزبان، می‌تواند از این مسیر استفاده کند، که به آن اجازه دسترسی هر چه بیشتر به مواد مغذی و غشاء های سلول میزبان را می دهد، که منجر به گسترش واکوئل های غشایی حاوی باکتری‌ می شود. برای این منظور یکسری از پروتئین های باکتری و میزبانی به کار گرفته می شوند. علاوه بر این، شناسایی دقیق و سریع بیماری حاد، این امکان را فراهم می کند که بیماری به شکل مزمن گسترش پیدا نکند. برای تشخیص دقیق و سریع باید روش های تشخیصی جدید ایجاد کرد که باعث سهولت در کشت میکروارگانیسم می شوند. این مقاله مروری به بررسی جدیدترین تحقیقات در مورد اپیدمیولوژی، پاتوژنز و ایجاد محیط های آکسنیک برای کوکسیلا بورنتی می پردازد. همچنین روابط پیچیده بین کوکسیلا برونتی و مسیر اتوفاژیک را بررسی می شود که برای تکثیر داخل سلولی و بقا آن در سلول میزبان به منظور ایجاد عفونت مؤثر ضروری می باشد.
کلیدواژه‌ها [English]
تب کیو, اپیدمیولوژی, بیماری زایی, تکثیر داخل سلولی, واکوئل های حاوی کوکسیلا
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