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Chaharmiri-Dokhaharani, Samaneh, Ghobad-Nejhad, Masoomeh, Moghimi, Hamid, Norouzi, Hooman, Moghaddam, Mohaddeseh. (1402). Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry. سامانه مدیریت نشریات علمی, (), -. doi: 10.22034/jmpb.2023.128804
Samaneh Chaharmiri-Dokhaharani; Masoomeh Ghobad-Nejhad; Hamid Moghimi; Hooman Norouzi; Mohaddeseh Moghaddam. "Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22034/jmpb.2023.128804
Chaharmiri-Dokhaharani, Samaneh, Ghobad-Nejhad, Masoomeh, Moghimi, Hamid, Norouzi, Hooman, Moghaddam, Mohaddeseh. (1402). 'Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22034/jmpb.2023.128804
Chaharmiri-Dokhaharani, Samaneh, Ghobad-Nejhad, Masoomeh, Moghimi, Hamid, Norouzi, Hooman, Moghaddam, Mohaddeseh. Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22034/jmpb.2023.128804

Bioactivity and Chemical Profiling of Medicinal Fungi Inonotus cuticularis and Inocutis levis (Hymenochaetaceae) using Chromatography and Mass Spectrometry

Journal of Medicinal plants and By-product
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 فروردین 1402    اصل مقاله (995.22 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22034/jmpb.2023.128804
نویسندگان
Samaneh Chaharmiri-Dokhaharani* 1؛ Masoomeh Ghobad-Nejhad1؛ Hamid Moghimi2؛ Hooman Norouzi3؛ Mohaddeseh Moghaddam1
1Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), P. O. Box 3353-5111, Tehran, Iran
2Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran, Iran
3Department of Horticultural Sciences, Faculty of Agriculture, Bu-Ali Sina University, Hamedan, Iran
چکیده
Polypore fungi are among the most preventable mushroom-forming fungi with known therapeutic potential, though only a few species have been securitized for their metabolites. This study examines the biological activity and bioactive compounds of Inocutis levis and Inonotus cuticularis collected in Iran. We examined the antimicrobial, antioxidant, and cytotoxic properties of n-hexane, acetone, and ethyl acetate extracts. Chemical profiles were assessed by chromatography and mass spectroscopy techniques. The acetonic extracts exhibited the highest antibacterial effect against all tested microbial strains. The IC50 values for DPPH and ABTS assays ranged from 144.98 – 469.02 μg/mL and 128.06 – 331.52 μg/mL, respectively. The MTT assays for both fungi indicated low toxicity on normal HDF cells with IC50 values ranging from 1447 to 1908 μg/mL. HPLC-DAD analysis showed a high level of gallic acid among other detected phenolic compounds. LC-ESI-MS/MS analysis displayed the presence of various sesquiterpenoids, furans, and styrylpyrone-class compounds. Inotilone, inonotin H and C, phellinulin B and M, cinnamic acid, p-coumaric acid, caffeic acid, phelligridin A and D, hispidin, and gallic acid were found in both species. Daedalin A is reported for the first time from the fungal family Hymenochaetaceae. In addition, several volatile compounds, including alkene hydrocarbons and some fatty acids, such as linoleic acid, were detected in GC-MS analyses. We suggest that I. levis and I. cuticularis have dual antibacterial and antioxidant properties and diverse metabolites, potentially opening new windows in future natural product-based medicine.
کلیدواژه‌ها
Bioactive compounds؛ Chemical composition؛ Daedalin A؛ Hispidin؛ Polypore fungi؛ Streptococcus mutans
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تعداد مشاهده مقاله: 60
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