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Elahinia, Ali, Hassanpour, Shahin, Ghotbitabar, Zahra. (1402). Effects of Ginsenosides on Pentylenetetrazol-induced convulsions during estrus cycle in rat. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2023.361208.2642
Ali Elahinia; Shahin Hassanpour; Zahra Ghotbitabar. "Effects of Ginsenosides on Pentylenetetrazol-induced convulsions during estrus cycle in rat". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.22092/ari.2023.361208.2642
Elahinia, Ali, Hassanpour, Shahin, Ghotbitabar, Zahra. (1402). 'Effects of Ginsenosides on Pentylenetetrazol-induced convulsions during estrus cycle in rat', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2023.361208.2642
Elahinia, Ali, Hassanpour, Shahin, Ghotbitabar, Zahra. Effects of Ginsenosides on Pentylenetetrazol-induced convulsions during estrus cycle in rat. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.22092/ari.2023.361208.2642

Effects of Ginsenosides on Pentylenetetrazol-induced convulsions during estrus cycle in rat

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 فروردین 1402
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2023.361208.2642
نویسندگان
Ali Elahinia1؛ Shahin Hassanpour* 2؛ Zahra Ghotbitabar1
1Graduate student, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Division of PhysiologyDepartment of Basic Sciences Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University-Tehran-Iran
چکیده
Ginseng known as king of all herbs antioxidant and anti-inflammatory activities and recently they becoming more concerned in the treatment of neurological diseases. Thus, this study aimed to determine effects of Ginsenosides on Pentylenetetrazol (PTZ)-induced epilepsy during estrus cycle. Thirty rats were randomly allocated into 5 groups control (saline), valproic acid (VPA, 75 mg/kg), ginsenosides (50 mg/kg), ginsenosides (100 mg/kg) and ginsenosides (150 mg/kg) with four subgroups (proestrus, estrus, metestrus and diestrus). Then, initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS) and seizure duration (SD) were determined. According to the results, ITMS and ITTS significantly increased in VPA treated group (P<0.05). Ginsenosides (100 and 150 mg/kg) administration significantly increased ITMS and ITTS (P<0.05). The ITMS and ITTS in ginsenosides-treated rats were significantly higher in luteal phases compared to follicular phase (P<0.05). Pretreatment with VPA significantly decreased SD comparison to control group (P<0.05). A significant decrease in SD was seen in rat pretreated with ginsenosides (100 and 150 mg/kg) (P<0.05). Seizure duration significantly decreased in in animals received ginsenosides in luteal phases compared to follicular phase (P<0.05). These results suggested ginsenosides has anticonvulsant effects, and it was more prominent during the luteal phase than the follicular phase.
کلیدواژه‌ها
Ginsenosides؛ PTZ؛ Seizure؛ Estrus cycle؛ Rat
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تعداد مشاهده مقاله: 25


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