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Elahinia, A, Hassanpour, Sh, Ghotbitabar, Z. (1402). Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat. سامانه مدیریت نشریات علمی, 78(4), 1359-1364. doi: 10.32592/ARI.2023.78.4.1359
A Elahinia; Sh Hassanpour; Z Ghotbitabar. "Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1359-1364. doi: 10.32592/ARI.2023.78.4.1359
Elahinia, A, Hassanpour, Sh, Ghotbitabar, Z. (1402). 'Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat', سامانه مدیریت نشریات علمی, 78(4), pp. 1359-1364. doi: 10.32592/ARI.2023.78.4.1359
Elahinia, A, Hassanpour, Sh, Ghotbitabar, Z. Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat. سامانه مدیریت نشریات علمی, 1402; 78(4): 1359-1364. doi: 10.32592/ARI.2023.78.4.1359

Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat

Archives of Razi Institute
مقاله 23، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1359-1364    اصل مقاله (551.53 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1359
نویسندگان
A Elahinia1؛ Sh Hassanpour* 2؛ Z Ghotbitabar1
1Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Ginseng is known as the king of all herbs in terms of antioxidant and anti-inflammatory activities and recently has become more involved in the treatment of neurological diseases. In this regard, this study aimed to determine the effects of Ginsenosides on pentylenetetrazol-induced epilepsy during the estrus cycle. For this purpose, 30 rats were randomly divided into five groups, namely control (saline), valproic acid (VPA, 75 mg/kg), Ginsenosides (50 mg/kg), Ginsenosides (100 mg/kg), and Ginsenosides (150 mg/kg) with four subgroups (proestrus, estrus, metestrus, and diestrus). Subsequently, the initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS), and seizure duration (SD) were determined. According to the results, ITMS and ITTS significantly increased in the VPA-treated group (P<0.05). Ginsenosides (100 and 150 mg/kg) administration significantly increased ITMS and ITTS (P<0.05). Moreover, the ITMS and ITTS in Ginsenosides-treated rats were significantly higher in luteal phases, compared to the follicular phase (P<0.05). In addition, pretreatment with VPA significantly decreased SD, compared to the control group (P<0.05). A significant decrease in SD was observed in the rats pretreated with ginsenosides (100 and 150 mg/kg) (P<0.05). Seizure duration significantly decreased in animals that received Ginsenosides in luteal phases, compared to the follicular phase (P<0.05). These results suggested that Ginsenosides have anticonvulsant effects that are more prominent during the luteal phase than the follicular phase.
کلیدواژه‌ها
Estrus cycle؛ Ginsenosides؛ PTZ؛ Rat؛ Seizure
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مراجع
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