اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,845
تعداد مقالات32,300
تعداد مشاهده مقاله41,383,165
تعداد دریافت فایل اصل مقاله18,557,808
Abbas Hussein Al-Saeed, S, Mizher Radhi, M, Numan Hamed, Z. (1402). Preparation of Nano-Medicine to Eliminate Helicobacter pylori Infection. سامانه مدیریت نشریات علمی, 78(4), 1313-1323. doi: 10.32592/ARI.2023.78.4.1313
S Abbas Hussein Al-Saeed; M Mizher Radhi; Z Numan Hamed. "Preparation of Nano-Medicine to Eliminate Helicobacter pylori Infection". سامانه مدیریت نشریات علمی, 78, 4, 1402, 1313-1323. doi: 10.32592/ARI.2023.78.4.1313
Abbas Hussein Al-Saeed, S, Mizher Radhi, M, Numan Hamed, Z. (1402). 'Preparation of Nano-Medicine to Eliminate Helicobacter pylori Infection', سامانه مدیریت نشریات علمی, 78(4), pp. 1313-1323. doi: 10.32592/ARI.2023.78.4.1313
Abbas Hussein Al-Saeed, S, Mizher Radhi, M, Numan Hamed, Z. Preparation of Nano-Medicine to Eliminate Helicobacter pylori Infection. سامانه مدیریت نشریات علمی, 1402; 78(4): 1313-1323. doi: 10.32592/ARI.2023.78.4.1313

Preparation of Nano-Medicine to Eliminate Helicobacter pylori Infection

Archives of Razi Institute
مقاله 18، دوره 78، شماره 4، مهر و آبان 2023، صفحه 1313-1323    اصل مقاله (592.96 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.32592/ARI.2023.78.4.1313
نویسندگان
S Abbas Hussein Al-Saeed1؛ M Mizher Radhi* 2؛ Z Numan Hamed1
1Laboratory Techniques Department, College of Health and Medical Techniques, Middle Technical University (MTU), Baghdad, Iraq
2Radiological Techniques Department, College of Health and Medical Techniques, Middle Technical University (MTU), Baghdad, Iraq
چکیده
Helicobacter pylori (H. pylori) is considered a challenging type of bacteria that is difficult to treat with the currently used antibiotics, such as amoxicillin, erythromycin, and metronidazole, which have proven ineffective against these bacteria. In this study, modern technology was used to treat these bacteria by converting the aforementioned antibiotics to their nano state using the lyophilization method and diagnosing them using scanning electron microscopy. A mixture of the three nano-antibiotics was prepared in the form of a nano-medicine, which was used to treat H. pylori bacteria in cultures and determine the effectiveness of nano-antibiotics and nano-medicine on these bacteria. The findings showed that nano-medicine was highly effective in inhibiting these bacteria at the lowest concentration (OD=0.042) and the highest concentration (OD=0.038), compared to the three micro-antibiotics individually. The OD values ​​of amoxicillin, azithromycin, and metronidazole were 0.523, 0.521, and 0.453, respectively. The OD values ​​of the three nano-antibiotics, including nano-amoxicillin, nano-azithromycin, and nano-metronidazole, were 0.386, 0.258, and 0.167, respectively. It was observed that the percentage of inhibition in each of the nano-antibiotics was higher than the inhibition in micro-antibiotics and that the nano-medicine had much higher inhibition than each of the three micro- and nano-antibiotics alike. The safety of using nano-antibiotics in the prepared medicine was confirmed using electrochemical technology and cyclic voltammetry to identify the electrochemical properties through oxidation and reduction in blood media. Based on the findings, only reduction peaks appeared, and there were no oxidation peaks in the prepared kit or for each of the three nano-antibiotics. It was found that they were all non-oxidants and could be used safely as good antioxidants in treatments. However, the same three micro treatments showed blood oxidation due to the appearance of oxidation peaks in all of them. The study proved that all H. pylori isolates are resistant to usable antibiotics. All of the antibiotics in the nano-medicine had an anti-bacterial effect, and the effect of the new form of antibiotic was proportional to the concentration of the antibiotic.
کلیدواژه‌ها
Cyclic voltammetry؛ H-pylori؛ Nano-antibiotic؛ Nano-medicine
سایر فایل های مرتبط با مقاله
مراجع
  1. Luigi S. Helicobacter pylori infection. 2021.
  2. Grande R, Sisto F, Puca V, Carradori S, Ronci M, Aceto A, et al. Antimicrobial and Antibiofilm Activities of New Synthesized Silver Ultra-NanoClusters (SUNCs) Against Helicobacter pylori. Front Microbiol. 2020;11:1705.
  3. Cardos IA, Zaha DC, Sindhu RK, Cavalu S. Revisiting Therapeutic Strategies for H. pylori Treatment in the Context of Antibiotic Resistance: Focus on Alternative and Complementary Therapies. Molecules. 2021;26(19).
  4. Alsaiari NS, Katubi KMM, Alzahrani FM, Siddeeg SM, Tahoon MA. The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review. Micromachines (Basel). 2021;12(3).
  5. Fateh R, Javadi A, Kardan-Yamch J, Ali Rahdar H, Amini M, Ghasemi F, et al. Construction of metronidazole capped in gold nanoparticles against Helicobacter pylori: antimicrobial activity improvement. Folia Med (Plovdiv). 2021;63(2):197-202.
  6. Wu T, Wang L, Gong M, Lin Y, Xu Y, Ye L, et al. Synergistic effects of nanoparticle heating and amoxicillin on H. pylori inhibition. J Magn Magn Mater. 2019;485:95-104.
  7. Silva FM, Eisig JN, Teixeira AC, Barbuti RC, Navarro-Rodriguez T, Mattar R. Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy. BMC Gastroenterol. 2008;8:20.
  8. Silva FM, Eisig JN, Chehter EZ, da Silva JJ, Laudanna AA. Low efficacy of an ultra-short term, once-daily dose triple therapy with omeprazole, azithromycin, and secnidazole for Helicobacter pylori eradication in peptic ulcer. Rev Hosp Clin Fac Med Sao Paulo. 2002;57(1):9-14.
  9. Hirsch FG, Texter EC, Jr., Wood LA, Ballard WC, Jr., Horna FE, Wright IS. The electrical conductivity of blood. I: Relationship to erythrocyte concentration. Blood. 1950;5(11):1017-35.
  10. Hrioua A, Loudiki A, Farahi A, Bakasse M, Lahrich S, Saqrane S, et al. Recent advances in electrochemical sensors for amoxicillin detection in biological and environmental samples. Bioelectrochemistry. 2021;137:107687.
  11. Fouladgar M, Hadjmohammadi MR, Khalilzadeh MA, Biparva P, Teymoori N, Beitollah H. Voltammetric determination of amoxicillin at the electrochemical sensor ferrocenedicarboxylic acid multi wall carbon nanotubes paste electrode. Int J Electrochem Sci. 2011;6(5):1355-66.
آمار
تعداد مشاهده مقاله: 3,187
تعداد دریافت فایل اصل مقاله: 415


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب